DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5112 and faah-3

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_500017.2	Gene:	faah-3 / 176916	WormBaseID:	WBGene00019068	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	591	Identity:	124/591 - (20%)
Similarity:	220/591 - (37%)	Gaps:	159/591 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SDRLLEFVLDWYLGEHKR--------VSGPPSLEQQTTITKSAVELAQQIRERRQRSYDIVKAYC 75
            :||.:.|  :|.....::        :|..|..|.:.::....:...:.:|..::::|
Worm    37 ADRKINF--EWAKNSFQKLDESRAVEISAKPFEELRNSLKNGEIGPVETLRAFQRKAY------- 92

  Fly    76 ERIESVNRDLNAVVDGPFPEALDQAREIDRKLDEKEYSDEDLRRLPFLGVPFSTKDSTAVAGRLH 140
            |..|..|     .|.....|||:.|..::....:..|     ::.|..|||.|.|:|..|.....
Worm    93 ESTEKTN-----CVCFFIQEALEIAENLEHLATDPNY-----QKPPLFGVPVSIKESIHVKNLDS 147

  Fly   141 TLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIGCTNNPYDLRRSVGGS 205
            |.|...:.:..|..::..|..:...||:....:|:|.........|.:.|.|.||.|..|..|||
Worm   148 TAGYAQKINNPSDANSVSVDQLIRLGAVPFVHTNIPIALLSYGCSNGVYGTTLNPLDNSRVPGGS 212

  Fly   206 SGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAGCTFRTGKEKDTMVCAGP 270
            |||||||::...:..|:|||:|||||.||..||:.|.|.:|......|.|......:..:...||
Worm   213 SGGEAALVSLGGSVLGIGTDVGGSIRTPASFCGLAGFKSSSDRSPQLGKTASIPGRQLLLSVEGP 277

  Fly   271 MSRSARDLLPMMQVLVE--------PSLKAK------LKLDQKV--DLKRLRYFYVSSNGMAQCN 319
            ::::       :.|.||        |.|..|      :|..:.:  ..|.|:..|.:.:|....:
Worm   278 IAKN-------IDVCVEYLRLKWNDPLLYKKDVYMPPVKFQENLYNSEKPLKIGYYTFDGYQTAS 335

  Fly   320 PIN----RETERVMYKIRKHFEAVSGKDVRHADLPYTKLTGKMWRYWMTQEPANFNLLLGNGAEL 380
            |..    |||..|:            |::.|..:|:.           ..:|.:...:...||
Worm   336 PAYQRAVRETVAVL------------KELGHELVPFE-----------VPQPDHMYSIFCAGA-- 375

  Fly   381 NPFVELFKKILGQSDYSMAAIYGLIDSVLPKEK-------------EKLMRE--ATAKCKKSVQD 430
                        .:|..:..:..|.:.::|.|.             ::|:|:  ...:.::.:|:
Worm   376 ------------TADGGLYLMDSLANDIIPPEADIGFPVAKLPHFIQRLLRKYWHHRRERQIIQE 428

  Fly   431 LLGD----------------DGVLFFHSSPRTA----------PFHYYPLVKFNDFAYFSLFNVL 469
            |..|                :.||...:....|          |.|..|.......:|.:|:|::
Worm   429 LPHDTEEMRQMHEKIEDYRHEFVLAMRAKKLDALVCPAFGCPPPHHGMPNKILGANSYPALYNLI 493

  Fly   470 HLPATQVPMGL------------------------DSK---GMPLGIQVVANPNNDRLCLAVAEE 507
            ...|..||:.:                        :||   |:|:.:|:...|..:.:||.:.::
Worm   494 DFAAGTVPVTVQKQEDEVELRKMKTEDSWDRRVVTESKNCIGLPVSVQIATPPYREEMCLRLLKQ 558

  Fly   508 LERTFG 513
            :|...|
Worm   559 VEAKIG 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	116/548 (21%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	111/520 (21%)
faah-3	NP_500017.2	Amidase	82..553	CDD:366635	113/531 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750