DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5112 and faah-4

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_499545.1	Gene:	faah-4 / 176620	WormBaseID:	WBGene00013232	Length:	647	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	136/560 - (24%)
Similarity:	232/560 - (41%)	Gaps:	106/560 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VSGPPSLEQ-QTTITK----SAVELAQQIRERRQRSYDIVKAYCERIESVNRDLNAVVDGPFPEA 96
            |.|..:.|| :||..:    ..:.|...::..:..:|.::.|:..|...||.::|.:.: ...||
Worm    74 VKGNETAEQIETTFNEILKLDLIALKSALQTDKYNAYTVLCAFVWRAIDVNSEINCITE-VIREA 137

  Fly    97 LDQAREIDRKLDEKEYSDEDLRRLPFLGVPFSTKDSTAVAGRLHTLGLLARKSERSTTDAECVRL 161
            .:.|..:|   |....:.|   :....|:|||.|.:..:.....|:||.....:..||....|:.
Worm   138 FNTAEALD---DNYAQTGE---KGQLFGLPFSVKSNFYMENYDVTVGLAKLLEQPKTTTCPMVQF 196

  Fly   162 MKESGAIIIATSNVPEVNKWIESRNMLIGCTNNPYDLRRSVGGSSGGEAALIAACCTGFGLGTDI 226
            :.:.||:....:|||:......|.|.:.|.|.||:|..|:.||||||||||:||....||:|:|:
Worm   197 LSDQGAVPFCLTNVPQGLLSYVSSNPIYGTTKNPWDFSRTPGGSSGGEAALLAAGGAAFGIGSDL 261

  Fly   227 GGSIRIPAFNCGIFGHKPTS---------------GAVNMA-GCTFRTGKEKDTMVCAGPMSRSA 275
            .||:||||..||:...|||.               |.:.:: |...|:.||::.::.........
Worm   262 AGSLRIPAAFCGLVTLKPTQDRLCVTDTHGGLPGRGRLGLSFGFYTRSVKEQEFLLGLIVGRSEY 326

  Fly   276 RDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNGMAQCNPINRETERVMYKIRKHFEAVS 340
            .:|.||       |..|||:...:.|.|.:..::|...    .||:.....|.:.:..|..:|..
Worm   327 LELCPM-------SSPAKLEKHIEKDQKLVIGWFVDDG----FNPVVPSNRRAVEETVKSLQAKG 380

  Fly   341 GK--DVRHADL----PYTKLTGKMWRYWMTQEPANFNLLLGNGAELNPFVELFKKILGQSDYSMA 399
            .:  :::.||:    |...:...::|..|....|..:.:.. |.:.:..::||.:::......:.
Worm   381 HQVVELKLADVSEEFPPFAVADMLFRNVMPDNGAYMSEMYA-GEQYDEHMKLFIRLVCLKQNFLV 444

  Fly   400 AI---YGLIDSVLPKEKEKLMREAT----------AKCKKSVQ--DLLGDDGVLFFHSSPRTA-- 447
            :.   ||    |:|..|..|.:...          |.|:::.:  |......:.::.|....|
Worm   445 SFLLRYG----VMPFAKLALSKRLACIGSAYNSDLAACRQNQENTDSYKLQWIRYWKSKKIDALI 505

  Fly   448 ---------PFHYYPLVKFNDFAYFSLFNVLHLPATQVPMG----------LD------------ 481
                     ||. ||....|......|||:|.:||..||:.          :|
Worm   506 CPSFITPAQPFE-YPAQLSNGAFITGLFNMLDVPAGVVPVSPVNQKDVDQLIDGFSTEGDLLLKK 569

  Fly   482 -------SKGMPLGIQVVANPNNDRLCLAVAEELERTFGG 514
                   :.|:|..:|||..||.:.:||.|...:|.:..|
Worm   570 QREAARGTTGLPNAVQVVTLPNCEEMCLRVMRLVEESAEG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	129/537 (24%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	123/509 (24%)
faah-4	NP_499545.1	Amidase	112..597	CDD:418511	123/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920