DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5112 and FAAH2

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_777572.2	Gene:	FAAH2 / 158584	HGNCID:	26440	Length:	532	Species:	Homo sapiens

Alignment Length:	526	Identity:	210/526 - (39%)
Similarity:	312/526 - (59%)	Gaps:	23/526 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALVHILSDRLLEFVLDWYLGEHKRVSGPPSLEQQT--TITK-----SAVELAQQIRERRQRSYDI 70
            |.:.:...|.|.|::. .:|....|.|.|....:|  .:|:     |.::||:.||:|:.:..|:
Human     7 ARIQLFLLRALGFLIG-LVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDV 70

  Fly    71 VKAYCERIESVNRDLNAVVDGPFPEALDQAREIDRKLDEKEYSDEDL-RRLPFLGVPFSTKDSTA 134
            |:||..||:.||..:|.:|...|.||:.:|..:|:||.||:..:..| .:.||||||.:.|::..
Human    71 VQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEATLENKWPFLGVPLTVKEAFQ 135

  Fly   135 VAGRLHTLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIGCTNNPYDLR 199
            :.|..::.||:.|:...:.|||..|.|:|.:|||.:..:|..|:..|.||.|.:.|.:||||||:
Human   136 LQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDLQ 200

  Fly   200 RSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAV-NMAGCTFRTGKEKD 263
            ..||||||||...:||.|:..|:|:|||||||:|||..|||||||:.|.| |........|.: :
Human   201 HIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLAVGAQ-E 264

  Fly   264 TMVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNGMA-QCNPINRETER 327
            ..:|.|||.|.|.||.||::|:..|.:| :||||.||.||.|:::::..:|.: ..:.::::...
Human   265 LFLCTGPMCRYAEDLAPMLKVMAGPGIK-RLKLDTKVHLKDLKFYWMEHDGGSFLMSKVDQDLIM 328

  Fly   328 VMYKIRKHFEAVSGKDVRHADLPYTKLTGKMWRYWMT------QEPANFNLLLG-NGAELNPFVE 385
            ...|:..|.|.:.|..|:|..|...|.:.::|...|:      :||..|..||| :|..::|..|
Human   329 TQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVSPLWE 393

  Fly   386 LFKKILGQSDYSMAAI-YGLIDSVL--PKEKEKLMREATAKCKKSVQDLLGDDGVLFFHSSPRTA 447
            |.|..||.|.|::.:| ..|::..|  ..||.:..:......:|.:.|:||||||..:.|.|..|
Human   394 LIKWCLGLSVYTIPSIGLALLEEKLRYSNEKYQKFKAVEESLRKELVDMLGDDGVFLYPSHPTVA 458

  Fly   448 PFHYYPLVKFNDFAYFSLFNVLHLPATQVPMGLDSKGMPLGIQVVANPNNDRLCLAVAEELERTF 512
            |.|:.||.:..:|||..:|:.|.||.||.|:||::||:||||||||.|.||.|.||||:.||:||
Human   459 PKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAKGLPLGIQVVAGPFNDHLTLAVAQYLEKTF 523

  Fly   513 GGWVPP 518
            ||||.|
Human   524 GGWVCP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	194/473 (41%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	181/445 (41%)
FAAH2	NP_777572.2	GatA	48..526	CDD:223232	196/479 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830