DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5112 and AgaP_AGAP009617

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_318647.4	Gene:	AgaP_AGAP009617 / 1278991	VectorBaseID:	AGAP009617	Length:	520	Species:	Anopheles gambiae

Alignment Length:	516	Identity:	283/516 - (54%)
Similarity:	383/516 - (74%)	Gaps:	3/516 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SHVLDALLALVHILSDRLLEFVLDWYLGEHKRVSGPPSLE-QQTTITKSAVELAQQIRERRQRSY 68
            :.:|.....|:|::.|::|...|.||.|..||..  |:|: ::..:|.||||||:.||.|....|
Mosquito     4 NRMLVYFFTLLHLVIDKVLYLCLKWYWGPSKRRC--PTLQRKRLLVTYSAVELARMIRTREVSCY 66

  Fly    69 DIVKAYCERIESVNRDLNAVVDGPFPEALDQAREIDRKLDEKEYSDEDLRRLPFLGVPFSTKDST 133
            |::.|:.:|:..||..:|||:||||.:||::||.||.:|.:....:.:|...|||||||:|||||
Mosquito    67 DVISAFIDRLNEVNPLVNAVLDGPFIDALEEARRIDERLQQGTIGEAELAAKPFLGVPFTTKDST 131

  Fly   134 AVAGRLHTLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIGCTNNPYDL 198
            ||..||||||::||::.|:.:||||||||||:|||||||:::||:|:|.|:||.:||.||||||.
Mosquito   132 AVKDRLHTLGIVARRTVRANSDAECVRLMKEAGAIIIATTSIPEINRWQETRNNIIGQTNNPYDN 196

  Fly   199 RRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAGCTFRTGKEKD 263
            ||:||||||||.||:|||.|..|||||||||||:|||.||::|||||:|.:|..||:.|||:|..
Mosquito   197 RRTVGGSSGGEGALLAACGTPIGLGTDIGGSIRMPAFYCGVYGHKPTTGIINTRGCSLRTGREPS 261

  Fly   264 TMVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNGMAQCNPINRETERV 328
            |||.||||:|.|.||||:|||||.|.....|:.|:.||:::|||||::.:|..:|:.:....::.
Mosquito   262 TMVVAGPMTRYATDLLPLMQVLVGPEKCTSLRFDEPVDVRKLRYFYITESGDIKCSAVQPSLQKA 326

  Fly   329 MYKIRKHFEAVSGKDVRHADLPYTKLTGKMWRYWMTQEPANFNLLLGNGAELNPFVELFKKILGQ 393
            |.::.:||..::...||...|..|..|..|||||||||||||..|||||..|:|.|||.||:.|:
Mosquito   327 MDRVVQHFGEIAPAGVRKVTLSGTDRTTNMWRYWMTQEPANFGTLLGNGKPLSPLVELAKKLTGR 391

  Fly   394 SDYSMAAIYGLIDSVLPKEKEKLMREATAKCKKSVQDLLGDDGVLFFHSSPRTAPFHYYPLVKFN 458
            |:|:||:||.|:|::||:|||.:::|.|.:|.:.:.:|||||||||:||:...||:||...|...
Mosquito   392 SEYTMASIYSLMDTLLPQEKEDVIKELTRRCDQELTELLGDDGVLFYHSTTHAAPYHYGAFVNVY 456

  Fly   459 DFAYFSLFNVLHLPATQVPMGLDSKGMPLGIQVVANPNNDRLCLAVAEELERTFGGWVPPF 519
            :|:|:.||||||:||||||:|||..|:||||||||:.|.||.|||||||:||.|.|.:|||
Mosquito   457 NFSYWCLFNVLHVPATQVPLGLDGDGLPLGIQVVASRNRDRHCLAVAEEIERVFNGRIPPF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	264/460 (57%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	245/432 (57%)
AgaP_AGAP009617	XP_318647.4	PRK07488	39..516	CDD:236030	268/476 (56%)
AgaP_AGAP009617	XP_318647.4	Amidase	67..500	CDD:302749	245/432 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	528	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44821
Inparanoid	1	1.050	589	1.000	Inparanoid score	I2473
OMA	1	1.010	-	-		QHG53387
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		oto110353
Panther	1	1.100	-	-	LDO	PTHR43372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X256
TreeFam	1	0.960	-	-
	13	12.940