Protein Alignment XNP and CHD1L

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_004275.4
• Gene: CHD1L / 9557
• HGNCID: 1916
• Length: 897
• Species: Homo sapiens
• Alignment Length: 948
• Identity: 214/948 - (22%)
• Similarity: 350/948 - (36%)
• Gaps: 317/948 - (33%)

  Fly   455 LKPHQVAGVKFMWDA----CFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGV 515
            |:.:|:.||.  |.|    |           .:||||...||||||.|.:.|  .:.:..|....
Human    46 LRSYQLEGVN--WLAQRFHC-----------QNGCILGDEMGLGKTCQTIAL--FIYLAGRLNDE 95

  Fly   516 DRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDM 580
            ...||:.|||.::||..|.   .:||.......|    ..||..|            .|:
Human    96 GPFLILCPLSVLSNWKEEM---QRFAPGLSCVTY----AGDKEER------------ACL----- 136

  Fly   581 YRILANEKAKGLRKKQREQLMQALVD------------PGPDLVVCDEGHLLKNEKTSISKAVTR 633
                    .:.|:::.|..::....:            |...||| ||.|.|||:.:.:.|.::.
Human   137 --------QQDLKQESRFHVLLTTYEICLKDASFLKSFPWSVLVV-DEAHRLKNQSSLLHKTLSE 192

  Fly   634 MRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKH 698
            ......::|||||:||:|:|.|.::.||:|:|..  ||.:..|:.     :|     :|:.....
Human   193 FSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFS--KEEVGDFIQ-----RY-----QDIEKESE 245

  Fly   699 RSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGA 763
            .:..|||||:..:.||..:.:|..||.|.|.|:|..:|.||:|.|
Human   246 SASELHKLLQPFLLRRVKAEVATELPKKTEVVIYHGMSALQKKYY-------------------- 290

  Fly   764 RLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKS 828
                                        |.:|.   .|::.|      |:|.|
Human   291 ----------------------------KAILM---KDLDAF------ENETA------------ 306

  Fly   829 DASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQK--DDPSEW----WKPFVE 887
                          ||.|.:|             :|      |.::|  |.|..:    .:||..
Human   307 --------------KKVKLQN-------------IL------SQLRKCVDHPYLFDGVEPEPFEV 338

  Fly   888 ERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGD 952
            ...|...  |.||.:|.:||....:.|.::|:|||..|.||:::.::                 |
Human   339 GDHLTEA--SGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYM-----------------D 384

  Fly   953 FKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDV 1017
            ::     |..|.|:|||...|:|....|.|......   :||:||||||:|:||.||:.|:..|.
Human   385 YR-----GYSYERVDGSVRGEERHLAIKNFGQQPIF---VFLLSTRAGGVGMNLTAADTVIFVDS 441

  Fly  1018 SWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQT 1082
            .:||.:|.|:..|.:|.||.|...:.|||...|:|:.||.:..:|......:|:    ..|:...
Human   442 DFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIE----GGHFTLG 502

  Fly  1083 DLMELYSYELKPSTEREMPI-----LPKDRLFAEILTEHEKLIFKYHEHDSLL------------ 1130
                    ..||:.:.::.:     ...|:|.|...:..:::     :.:|:|
Human   503 --------AQKPAADADLQLSEILKFGLDKLLASEGSTMDEI-----DLESILGETKDGQWVSDA 554

  Fly  1131 ---------EQEEHEN-------------LTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGN 1173
                     :|||.:|             .::|:|||.......:||...:|||.....||. |:
Human   555 LPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNK-GS 618

  Fly  1174 QVMGQFGNASGSVTSNKIF----------------GFRSDILLQLLNMKISKDHQ------ELNQ 1216
            .::.  |...||....::.                ..|..::.:....|...:|:      |.|.
Human   619 VLIP--GLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWESNN 681

  Fly  1217 NQVIQLVPTYLQQLYNEMNNGDPTM----YKD-----LLNLHSNIVHPSGMYMNPLLYANQNPNA 1272
            .|...|.....:.  .::.||:.:.    |:|     |..:..::.||.....:.|:....:.:.
Human   682 YQSFCLPSEESEP--EDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSG 744

  Fly  1273 AGYNQGTGGVPPMAGGSVAHGPPAAPAPGFEPDKVYEI 1310
               :.|.||:           ..|......||.|:||:
Human   745 ---HWGRGGL-----------FTALEKRSAEPRKIYEL 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	1/4 (25%)
		HepA	<382..1071	CDD:440319	162/637 (25%)
		DEXHc_ATRX	455..699	CDD:350826	67/259 (26%)
CHD1L	NP_004275.4	PLN03142	46..699	CDD:215601	197/863 (23%)
		DEAH box	174..177		2/2 (100%)
		Regulatory linker segment (RLS). /evidence=ECO:0000269|PubMed:33357431	601..635		10/36 (28%)
		Required for ATPase activity. /evidence=ECO:0000269|PubMed:29220653	615..673		8/60 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..654		1/25 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..711		4/25 (16%)
		Macro_Poa1p-like_SNF2	716..866	CDD:394880	13/67 (19%)