Protein Alignment XNP and ISW1

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_009804.1
• Gene: ISW1 / 852547
• SGDID: S000000449
• Length: 1129
• Species: Saccharomyces cerevisiae
• Alignment Length: 1092
• Identity: 251/1092 - (22%)
• Similarity: 423/1092 - (38%)
• Gaps: 338/1092 - (30%)

  Fly   275 TTSKKSRQRRSKSESEADSD----YEAPAAEEEEEEERKSSG-----DEEEAANSSDSEV-MPQR 329
            |..:|..:..|.:|.:.|.:    ..|...:|:::.:..|||     .||...|....:| :|
Yeast    17 TRMRKKHENNSCNEKDKDENLFKIILAIFLQEKKKYDCISSGSIMTASEEYLENLKPFQVGLP-- 79

  Fly   330 KRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKR-----------KHI 383
                             |.:.:..|.|..:|..:..:.|.:|     ..||           ||.
Yeast    80 -----------------PHDPESNKKRYLLKDANGKKFDLEG-----TTKRFEHLLSLSGLFKHF 122

  Fly   384 RKIIKTKD------LDLTTKEAA------KEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDF 436
            .:....||      ||:..:..|      |.:|.||::.|..:   :...:|.|..:.:|.: :|
Yeast   123 IESKAAKDPKFRQVLDVLEENKANGKGKGKHQDVRRRKTEHEE---DAELLKEEDSDDDESI-EF 183

  Fly   437 DEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVT 501
            ......|.:.      .:|:|:|:.||.::         .|..|.....|||..||||||||.::
Yeast   184 QFRESPAYVN------GQLRPYQIQGVNWL---------VSLHKNKIAGILADEMGLGKTLQTIS 233

  Fly   502 LSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNE 566
            ....|....:..|  ..|:|:|.||:|||.||...|..     |:..:.:...|::...:.:..
Yeast   234 FLGYLRYIEKIPG--PFLVIAPKSTLNNWLREINRWTP-----DVNAFILQGDKEERAELIQKK- 290

  Fly   567 WFNEGGVCILGYDM------YRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKT 625
                    :||.|.      |.|:..||:. |:|...|            .::.||.|.:|||::
Yeast   291 --------LLGCDFDVVIASYEIIIREKSP-LKKINWE------------YIIIDEAHRIKNEES 334

  Fly   626 SISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTE 690
            .:|:.:....::.|:::|||||||||.|.:.::.|:.|::....:::.:.|        .::|||
Yeast   335 MLSQVLREFTSRNRLLITGTPLQNNLHELWALLNFLLPDIFSDAQDFDDWF--------SSESTE 391

  Fly   691 RDL-RLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQS 754
            .|. :::|.    ||.:|:..:.||..|.:...|.||.|..:|..:|.:|:|.|
Yeast   392 EDQDKIVKQ----LHTVLQPFLLRRIKSDVETSLLPKKELNLYVGMSSMQKKWY----------- 441

  Fly   755 GGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNS 819
                                                 |::|..|...:.|            ||.
Yeast   442 -------------------------------------KKILEKDLDAVNG------------SNG 457

  Fly   820 SDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKP 884
            |...:|...:..|          :.||..|                      .....|.:|...|
Yeast   458 SKESKTRLLNIMM----------QLRKCCN----------------------HPYLFDGAEPGPP 490

  Fly   885 FVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGD 949
            :..:..|  |:::.||.:|.:||::.:..|.::|:|||..:.||::|.:
Yeast   491 YTTDEHL--VYNAAKLQVLDKLLKKLKEEGSRVLIFSQMSRLLDILEDY---------------- 537

  Fly   950 VGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVI 1014
                  |:....:|.|:|||.:.|.|......: |..:.:..:||::||||||||||.:|:.||:
Yeast   538 ------CYFRNYEYCRIDGSTAHEDRIQAIDDY-NAPDSKKFVFLLTTRAGGLGINLTSADVVVL 595

  Fly  1015 FDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHY 1079
            :|..|||..|.|::.|.:|.||.|...::||:...::|:|:.||     ||.|..:|:..|.:
Yeast   596 YDSDWNPQADLQAMDRAHRIGQKKQVKVFRLVTDNSVEEKILER-----ATQKLRLDQLVIQQ-- 653

  Fly  1080 NQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKL-IFK--------------YHEHDSL 1129
            |:|.|           .::|.....||.|.:.|  :|... :||              ..|....
Yeast   654 NRTSL-----------KKKENKADSKDALLSMI--QHGAADVFKSGTSTGSAGTPEPGSGEKGDD 705

  Fly  1130 LEQEEHENLTEEERKSAWAEYEAEKTRTVQA-SQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFG 1193
            ::.:|....:|.:.||..|:||......:|. :|..:|:.|              |.....||
Yeast   706 IDLDELLLKSENKTKSLNAKYETLGLDDLQKFNQDSAYEWN--------------GQDFKKKI-- 754

  Fly  1194 FRSDILLQLLNMKISKDHQELNQNQVIQLVPTYLQQLYNEMNNGDPTMYKDLLN----------- 1247
             :.||:..||   ::...:|..:|..|.                  ..|||:||
Yeast   755 -QRDIISPLL---LNPTKRERKENYSID------------------NYYKDVLNTGRSSTPSHPR 797

  Fly  1248 ------LHSNIVHPSGMYMNPLLYANQNPNAAGYNQGTGGVPPMAGGSVAHG 1293
                  .||:.:.|..:   .:||..:....|   :.||.||.|.....|:|
Yeast   798 MPKPHVFHSHQLQPPQL---KVLYEKERMWTA---KKTGYVPTMDDVKAAYG 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	42/217 (19%)
		HepA	<382..1071	CDD:440319	174/707 (25%)
		DEXHc_ATRX	455..699	CDD:350826	69/250 (28%)
ISW1	NP_009804.1	PLN03142	108..1057	CDD:215601	229/977 (23%)