Protein Alignment XNP and FUN30

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_009383.1
• Gene: FUN30 / 851214
• SGDID: S000000017
• Length: 1131
• Species: Saccharomyces cerevisiae
• Alignment Length: 1170
• Identity: 293/1170 - (25%)
• Similarity: 468/1170 - (40%)
• Gaps: 251/1170 - (21%)

  Fly    29 RRESATESKSAS--ESESSP------PRSNT-KQSRTHKNV-KASGKATV----SSSSDSDQAVA 79
            :|::.|.:|:||  :||:.|      |.:|| :.|..|.|: ..|.|.||    :|..|....|.
Yeast   114 QRQNWTWNKNASPKKSETPPPVKKSLPLANTGRLSSIHGNINNKSSKITVAKQKTSIFDRYSNVI 178

  Fly    80 NSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKS 144
            |......|......|....|.||..:...|.|..|..|.......:||..: |..::..|.|.:.
Yeast   179 NQKQYTFELPTNLNIDSEALSKLPVNYNKKRRLVRADQHPIGKSYESSATQ-LGSAREKLLANRK 242

  Fly   145 RNKNASIIELSDSEEVDEEEESLLV---------------AIPLPKEAQQTKPEK---NSSKASK 191
            ..::|     :|::|  |||||::.               .|.|.::..|...:.   :.|..|.
Yeast   243 YGRHA-----NDNDE--EEEESMMTDDDDASGDDYTESTPQINLDEQVLQFINDSDIVDLSDLSD 300

  Fly   192 ESIEKRQKAQKEATTSSARAIRSVNGTRRG---SLSSERSSRASSSRAESPPRPKRCVVRLKRVS 253
            .::.|.|........||..|..:.|...:.   :.|::|..||::|..||    :|.:.::.:..
Yeast   301 TTMHKAQLIASHRPYSSLNAFVNTNFNDKDTEENASNKRKRRAAASANES----ERLLDKITQSI 361

  Fly   254 LPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAA 318
            ..........||.||..:...:..||...:.....||.|.   ....|:::::....:.|...:.
Yeast   362 RGYNAIESVIKKCSSYGDLVTSQMKKWGVQVEGDNSELDL---MNLGEDDDDDNDDGNNDNNNSN 423

  Fly   319 NSSDSEVMPQRKRRRKKSESDKGSSDFE------PEEKQKKKGRKRIKKTSSGESDGDGDDDKQK 377
            |::.:......|.:.......:|..:..      |.....::..|||:.|:..:...|.|||
Yeast   424 NNNTAGADATSKEKEDTKAVVEGFDETSAEPTPAPAPAPVERETKRIRNTTKPKVVEDEDDD--- 485

  Fly   378 NKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEE--- 439
                     :..:.:|....::..|:||..:..||    ||.   :.|.||.::...|.|::
Yeast   486 ---------VDLEAIDDELPQSEHEDDDYEEEDED----YND---EEEDVEYDDGDDDDDDDDEF 534

  Fly   440 ----------------SKKALLQVDKG---LLK---KLKPHQVAGVKFMWDACFETLKESQEKPG 482
                            .:|.:::..||   ||.   .||.:|..|:.::     ..|.:::
Yeast   535 VATRKNTHVISTTSRNGRKPIVKFFKGKPRLLSPEISLKDYQQTGINWL-----NLLYQNK---- 590

  Fly   483 SGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIE 547
            ..||||..||||||.||::. ...|......|..  |::.|.||:.||.|||   .|||....||
Yeast   591 MSCILADDMGLGKTCQVISF-FAYLKQINEPGPH--LVVVPSSTLENWLREF---QKFAPALKIE 649

  Fly   548 VYDISRYKDKPTR-IFKLNEWFNEGGVCILGYDM----YRILANEKAKGLRKKQREQLMQALVDP 607
            .|..|..:.:..| |.:.|..         .||:    |.:.|..|......|.|..
Yeast   650 PYYGSLQEREELRDILERNAG---------KYDVIVTTYNLAAGNKYDVSFLKNRNF-------- 697

  Fly   608 GPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEY 672
              ::||.||||:|||..:.....:.::|...|::||||||||||:|...:::|:.|||..:.||.
Yeast   698 --NVVVYDEGHMLKNSTSERFAKLMKIRANFRLLLTGTPLQNNLKELMSLLEFIMPNLFISKKES 760

  Fly   673 MNRFVNPITNGQYTDSTERDLRLMKHRSHILHK-LLEGCIQRRDYSVLAPYLPPKHEYVVYTTLS 736
            .:....  ...:.||..:....|:...:....| :::..|.||....:..:|||||.::.|..|:
Yeast   761 FDAIFK--QRAKTTDDNKNHNPLLAQEAITRAKTMMKPFILRRRKDQVLKHLPPKHTHIQYCELN 823

  Fly   737 ELQQKLYG---YYMTTHREQSGGDVVGKGARLFQDFQD---------LRRIWTHPMNLR-VNSDN 788
            .:|:|:|.   ..:..|:.......:.|.|:.....|.         ||:...||:..| :.:|.
Yeast   824 AIQKKIYDKEIQIVLEHKRMIKDGELPKDAKEKSKLQSSSSKNLIMALRKASLHPLLFRNIYNDK 888

  Fly   789 VIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAG 853
            :|.|         |...|.     ||.|...:.:.|..|.|.|..
Yeast   889 IITK---------MSDAIL-----DEPAYAENGNKEYIKEDMSYM-------------------- 919

  Fly   854 GGDSDSDLEML-GGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGD-- 915
               :|.:|..| .......|..:....||.:             |.|:..|.:||:  ..|.|
Yeast   920 ---TDFELHKLCCNFPNTLSKYQLHNDEWMQ-------------SGKIDALKKLLK--TIIVDKQ 966

  Fly   916 -KLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMC 979
             |:|:||...|.||::|..||.:|     |:|                 .|||||..|..|:.:.
Yeast   967 EKVLIFSLFTQVLDILEMVLSTLD-----YKF-----------------LRLDGSTQVNDRQLLI 1009

  Fly   980 KQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYR 1044
            .:|....::  .:|::||:|||.|||||.||.|:|||.|:||..|.|:..|.:|.||.|...|..
Yeast  1010 DKFYEDKDI--PIFILSTKAGGFGINLVCANNVIIFDQSFNPHDDRQAADRAHRVGQTKEVNITT 1072

  Fly  1045 LIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLME----------LYSYELKPSTERE 1099
            ||...::|:|::  |:||...|.    :..||......|::|          :|....||...:|
Yeast  1073 LITKDSIEEKIH--QLAKNKLAL----DSYISEDKKSQDVLESKVSDMLEDIIYDENSKPKGTKE 1131

  Fly  1100  1099
            Yeast  1132  1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	61/323 (19%)
		HepA	<382..1071	CDD:440319	199/736 (27%)
		DEXHc_ATRX	455..699	CDD:350826	76/248 (31%)
FUN30	NP_009383.1	HepA	<571..1093	CDD:440319	180/635 (28%)