Protein Alignment XNP and TTF2

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_016858039.1
• Gene: TTF2 / 8458
• HGNCID: 12398
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1271
• Identity: 273/1271 - (21%)
• Similarity: 442/1271 - (34%)
• Gaps: 410/1271 - (32%)

  Fly    16 PLTTDDSNSSSVSRR-ESATESKSASESESSPP----RSNTKQSRTHKNVKASGKATVSSSSDSD 75
            |....||...|||.: :.|:|:...|.:....|    ..|.:.:...:.:|..|:   ...:|..
Human    93 PWQDPDSKEHSVSNKSQHASETFHHSSNWLRNPFKVLDKNQEPALWKQLIKGEGE---EKKADKK 154

  Fly    76 QAVANSSANDEEKEPVCKIRIVPLEKLLAS---PKTKER-PSRGSQQKNVTI-----------ND 125
            |........|::||...::    :||.|:|   ||.|:. .....|::...|           .|
Human   155 QREKGDQLFDQKKEQKPEM----MEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGGTHKRD 215

  Fly   126 SSD--EEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSK 188
            .|:  .:..:|::|..|:..|:.|::     ..|::|..|.|      ||.::..|..|:   :.
Human   216 FSEIKSQQCQGNELTRPSASSQEKSS-----GKSQDVQRESE------PLREKVTQLLPQ---NV 266

  Fly   189 ASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSS-RASSSRAESPPRPKRCVVRLKRV 252
            .|..||.|.||.                    |.|:.|.:: .|..::|:..|.     ::..:.
Human   267 HSHNSISKPQKG--------------------GPLNKEYTNWEAKETKAKDGPS-----IQATQK 306

  Fly   253 SLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEA 317
            |||:....::|:..|..:.                        ..|||:........|.|:..||
Human   307 SLPQGHFQERPETHSVPAP------------------------GGPAAQAAPAAPGLSLGEGREA 347

  Fly   318 ANSSDSE------------------------------VMPQRKRRRKKSESDKGSSDFEPEE--- 349
            |.|||.|                              ..|.|..:||.|.:...|...||.:
Human   348 ATSSDDEEEDDVVFVSSKPGSPLLFDSTLDLETKENLQFPDRSVQRKVSPASGVSKKVEPSDPVA 412

  Fly   350 ---------KQKK-------------KGRKRIKK-----------TSSGESDGDGDDDKQKNKRK 381
                     ||||             ||:|.||:           |.|.|...:...:.|..::.
Human   413 RRVYLTTQLKQKKSTLASVNIQALPDKGQKLIKQIQELEEVLSGLTLSPEQGTNEKSNSQVPQQS 477

  Fly   382 HIRK-------IIKTKDL---------DLTTKEAAK-EEDDRRKRIEDRQKLY----NRIFV--- 422
            |..|       ::..:.|         .|..|.|.: ......:.......||    |:..|
Human   478 HFTKTTTGPPHLVPPQPLPRRGTQPVGSLELKSACQVTAGGSSQCYRGNTYLYAGHTNQDHVHAV 542

  Fly   423 -KSESVEINELVLDFDEESKKALLQVD-KGLLKKLKPHQVAGVKF-MWDACFETLKESQEKPGSG 484
             |..|..|.:|....:....:.::..| .||...|..||...:.: :|       :||| ||..|
Human   543 WKITSEAIGQLHRSLESCPGETVVAEDPAGLKVPLLLHQKQALAWLLW-------RESQ-KPQGG 599

  Fly   485 CILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDR-------------------VLIISPLSTVNNW 530
             |||..|||||||.::.|..|.....::...::                   .|||.|.|.:::|
Human   600 -ILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTALTWLSKDDSCDFTSHGTLIICPASLIHHW 663

  Fly   531 AREFTSWMKFANRNDIEVYDISRY----KDKPTRIFKLNEWFNEGGVCILGYDM----YRILANE 587
            ..|..   |..|.|.:.||   .|    :|...|:...             ||:    |.::|.|
Human   664 KNEVE---KRVNSNKLRVY---LYHGPNRDSRARVLST-------------YDIVITTYSLVAKE 709

  Fly   588 KAKGLRKKQREQLMQALVDPGPDL-------------------------------------VVCD 615
            ..   ..||..::      ||.:|                                     ::.|
Human   710 IP---TNKQEAEI------PGANLNVETLSIHYGSGAVSSRAARFPLQGTSTPLLRIAWARIILD 765

  Fly   616 EGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPI 680
            |.|.:||.:...|.||.:::...|..:||||:||||.:.|.:::|::   ...:.|: |.:.:.:
Human   766 EAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR---CSPFDEF-NLWRSQV 826

  Fly   681 TNG---------------------QYTDSTERDLRLMKHRSHILH--KLLEGCIQRRDYSVLAPY 722
            .||                     ...|||.|.|.::..|...||  ||.|
Human   827 DNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVILPQRKFQLHHLKLSE-------------- 877

  Fly   723 LPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSD 787
                .|..||.......:.....|:..|  :|.|:..|:                       :.:
Human   878 ----DEETVYNVFFARSRSALQSYLKRH--ESRGNQSGR-----------------------SPN 913

  Fly   788 NVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSD--------ASMSGLAASSGKVKK 844
            |..::..|.        |..:|....|||.:...|.....|.        ..:|.|.::...::.
Human   914 NPFSRVALE--------FGSEEPRHSEAADSPRSSTVHILSQLLRLRQCCCHLSLLKSALDPMEL 970

  Fly   845 RKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWK---PFVEERELNNVHHSPKLLILLRL 906
            :       |.|...|..|.|..| ..|.::..:||....   .|.:......:..|.|:..||..
Human   971 K-------GEGLVLSLEEQLSAL-TLSELRDSEPSSTVSLNGTFFKMELFEGMRESTKISSLLAE 1027

  Fly   907 LQ--QCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGS 969
            |:  |..:...|.::.||....|.|:...|.                      ..|..|..:|||
Human  1028 LEAIQRNSASQKSVIVSQWTNMLKVVALHLK----------------------KHGLTYATIDGS 1070

  Fly   970 CSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRF 1034
            .:.:||..:.:.||:  :...::.|||..|||:|:||...|.:.:.|:.||||.:.|:..|:||.
Human  1071 VNPKQRMDLVEAFNH--SRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRV 1133

  Fly  1035 GQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVI 1070
            ||.|...|:|.:..||:|:|:.:.|..|:..||:|:
Human  1134 GQQKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVL 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	72/379 (19%)
		HepA	<382..1071	CDD:440319	181/816 (22%)
		DEXHc_ATRX	455..699	CDD:350826	75/329 (23%)
TTF2	XP_016858039.1	zf-GRF	4..39	CDD:480736
		PTZ00108	<147..378	CDD:240271	58/300 (19%)
		HepA	<566..1170	CDD:440319	167/728 (23%)
		DEXHc_TTF2	577..848	CDD:350830	70/311 (23%)