Protein Alignment XNP and CHD6

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_016883588.1
• Gene: CHD6 / 84181
• HGNCID: 19057
• Length: 2716
• Species: Homo sapiens
• Alignment Length: 1174
• Identity: 258/1174 - (21%)
• Similarity: 443/1174 - (37%)
• Gaps: 383/1174 - (32%)

  Fly   172 PLPKEAQQTKPEKNSSKASKESIEK-RQKAQKEATTSSARAIRSVNG-------------TRRGS 222
            |.|.:....:.||....||....:| ...|::||.|...|.:.|.||             .|:..
Human    36 PSPFDCSTDQEEKIEDVASHCLPQKDLYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKK 100

  Fly   223 LSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKP--AQKPKKMSSDSE-EAATTSKKSRQRR 284
            ...::...|..|: :..|:|||     ||......:|  |::|||.....| :....:||:|:.|
Human   101 EPGDQEGAAKGSK-DREPKPKR-----KREPKEPKEPRKAKEPKKAKEHKEPKQKDGAKKARKPR 159

  Fly   285 SKSESEADSDYEAPAAEEEEEEERKSSGD------EEEAANSSDSEVMPQRKRRRKKSESDKGSS 343
            .             |:..:|.:|::|..|      ..:|:.......:.::|:.::|||:...|.
Human   160 E-------------ASGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESL 211

  Fly   344 DFE----------PEE------KQKKKGRKRIKKTSSGES------DGDGD-------------- 372
            :.:          |||      .||::..:::|:....|.      |.||:
Human   212 ELDQGLTNPSLRSPEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALS 276

  Fly   373 --------DDKQKNKRKHIRKIIKTK------------DLDL----------------TTKEAAK 401
                    ::..::....|.||:.:|            ||:|                |.:|..|
Human   277 ASTLAWQAEEPPEDDANIIEKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEK 341

  Fly   402 EE--DDRRKRIEDRQKLYNRIFVKSES-------VEINELV-----------------------L 434
            :.  ..:.||..::|.....||.:.:.       ||::.::                       |
Human   342 DPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSL 406

  Fly   435 DFDEESKKALLQVDKGLLKKLKPHQV-AGVKFM-------WDACFETLKESQEKPGS-------- 483
            .::|.:.:....||...:|:.:..|| ..:|.:       |    :.|::|:|...|
Human   407 PYEESTWELEEDVDPAKVKEFESLQVLPEIKHVERPASDSW----QKLEKSREYKNSNQLREYQL 467

  Fly   484 --------------GCILAHCMGLGKTLQVVT-LSHTLLVNTRRTGV-DRVLIISPLSTVNNWAR 532
                          .||||..||||||:|.:| ||...|     .|: ...|||:||||:.||.|
Human   468 EGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFL-----RGIHGPFLIIAPLSTITNWER 527

  Fly   533 EFTSWMKF---------ANRNDIEVYDISRYKDKP----TRIFKLNEWFNEGGVCILGYDMYRIL 584
            ||.:|.:.         .:|..|:.|::. |:|..    :.:||.:       |.|..::|  ||
Human   528 EFRTWTEMNAIVYHGSQISRQMIQQYEMV-YRDAQGNPLSGVFKFH-------VVITTFEM--IL 582

  Fly   585 ANEKAKGLRKKQREQLMQALVDPGPDL-------VVCDEGHLLKNEKTSISKAVTRMRTKRRIVL 642
            |:                     .|:|       |:.||.|.|||....:.:.:..|..:.:::|
Human   583 AD---------------------CPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLL 626

  Fly   643 TGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLL 707
            |||||||::.|.:.::.|::|:...:...::..|      |..  .||..::.       |..:|
Human   627 TGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEF------GDL--KTEEQVKK-------LQSIL 676

  Fly   708 EGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGA------RLF 766
            :..:.||....:...|.||.|.::...|:.:|:|.|...:     :.....:.|||      .|.
Human   677 KPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAIL-----EKNFSFLTKGANQHNMPNLI 736

  Fly   767 QDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDAS 831
            ....:||:...||..:....:.::                     ||...::|.|:     .|..
Human   737 NTMMELRKCCNHPYLINGAEEKIL---------------------EDFRKTHSPDA-----PDFQ 775

  Fly   832 MSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHH 896
            :..:..::|
Human   776 LQAMIQAAG-------------------------------------------------------- 784

  Fly   897 SPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGK 961
              ||:::.:||.:..|.|.|:|:|||.::.||::|.:|.     .:.|.:|
Human   785 --KLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLI-----QRRYTYE-------------- 828

  Fly   962 DYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQ 1026
               |:||......|:|...:|....:.|. :||:.||||||||||.||:..:|||..|||.:|.|
Human   829 ---RIDGRVRGNLRQAAIDRFCKPDSDRF-VFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQ 889

  Fly  1027 SIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYE 1091
            :..|.:|.||.|...:||||...:.|::::::...|....|.|:  |.|:|......:.:|...|
Human   890 AQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVL--QDINRKGGTNGVQQLSKME 952

  Fly  1092 LKPSTEREMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKS---AWAEYEAE 1153
            ::       .:|.|....|.:..|.|...|...:.|.:|::..|....:.|.|.   |.|.:.|.
Human   953 VE-------DLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVAS 1010

  Fly  1154 KTRT 1157
            ..||
Human  1011 GNRT 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	76/413 (18%)
		HepA	<382..1071	CDD:440319	182/806 (23%)
		DEXHc_ATRX	455..699	CDD:350826	75/295 (25%)
CHD6	XP_016883588.1	PTZ00449	<105..374	CDD:185628	54/287 (19%)
		CD1_tandem_CHD5-9_like	289..354	CDD:349315	12/64 (19%)
		CD2_tandem_CHD5-9_like	373..431	CDD:349310	7/57 (12%)
		PLN03142	461..>986	CDD:215601	165/696 (24%)
		DEXHc_CHD6	462..683	CDD:350816	69/271 (25%)
		PHA03247	<2320..2694	CDD:223021
		BRK	2403..2438	CDD:470653