DRSC/TRiP Functional Genomics Resources

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Protein Alignment XNP and Ino80

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_080850.2 Gene:Ino80 / 68142 MGIID:1915392 Length:1559 Species:Mus musculus


Alignment Length:1392 Identity:306/1392 - (21%)
Similarity:503/1392 - (36%) Gaps:428/1392 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 VSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRG---SQQKNVTINDSSDE 129
            :||....|....|:....|..:|:.:::..|...||.  :|....|.|   ....|..:...|..
Mouse    46 ISSDDSEDGLDDNNPLLPESGDPLIQVKEEPPNSLLG--ETSGASSSGLLNPYSLNGVLQSESKS 108

  Fly   130 EPLKG-----SKLVLPARKSRNKNASIIELSD--------SEEVDEEEESL---------LVAIP 172
            :  ||     |||    :|||....||: |||        ||:.|:|||.|         ::.:.
Mouse   109 D--KGNLYNFSKL----KKSRKWLKSIL-LSDESSEADSQSEDNDDEEEELSLSREELHNMLRLH 166

  Fly   173 LPKEAQQTKPEKNSS-------------------KASKESIEKRQKAQKEATTSSARAIRSVNGT 218
            ..|:..|.|..|:..                   :..:..:..::|..||.....|: ::.|...
Mouse   167 KYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEDKKLKAK-LKKVKKK 230

  Fly   219 RR--GSLSSERSSR---------ASSSRAESPPRPKRCVVRLKR---------VSLPKTKPAQKP 263
            ||  ...|||.|.|         |..|....||..|:..:.:::         :|:.|.:..:..
Mouse   231 RRRDEEFSSEESPRHHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKVWLSIVKKELPKAN 295

  Fly   264 KKMSSDSEEAATTSKK------SRQRRSKSESEADSDYEAPAA--------------EEEEEEER 308
            |:.||......|.|:|      ...||:..:::.:.....|.|              |:.|:|.|
Mouse   296 KQKSSARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARRLTKEMLLYWKKYEKVEKEHR 360

  Fly   309 KSSGDEEEAANSSDSEVMPQRKRRRK---------------KSESDKGSSDFEPEEKQKKKGRKR 358
            |.:..|.......|.|:...::::||               ..:.|.|....:.|..:|.:....
Mouse   361 KRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRDMGHDGIQEEILRKLEDSST 425

  Fly   359 IKKTSSG--------ESDGDGDDDKQ---KNKRK--HIRKIIKTKDLDLTTKEAAKEEDDRRKRI 410
            .::...|        :.|.|.:..|.   ||...  ||.: .:|:..|    |.|||......|.
Mouse   426 QRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQ-ARTRSFD----EDAKESRAAALRA 485

  Fly   411 EDRQ-----KLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDAC 470
            .|:.     :.|:   :.:.|:...|   |..:.:      :..|   |||.:|:.|:.::    
Mouse   486 ADKSGSGFGESYS---LANPSIRAGE---DIPQPT------IFNG---KLKGYQLKGMNWL---- 531

  Fly   471 FETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFT 535
             ..|.|.    |...|||..||||||:|.:.|...|.......|  ..|||||.||:|||.:|||
Mouse   532 -ANLYEQ----GINGILADEMGLGKTVQSIALLAHLAERENIWG--PFLIISPASTLNNWHQEFT 589

  Fly   536 SWM-KF------ANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLR 593
            .:: ||      .|.:|.:|  |.|:..:.| ::..:..|:   |.|..|.:.       .:.::
Mouse   590 RFVPKFKVLPYWGNPHDRKV--IRRFWSQKT-LYTQDAPFH---VVITSYQLV-------VQDVK 641

  Fly   594 KKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMI 658
            ..||.:.         ..:|.||...||:..:...|.:.:.:.:.|::|||||:||.:.|.:.::
Mouse   642 YFQRVKW---------QYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALL 697

  Fly   659 QFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYL 723
            .|:.|.|..:::|:...|...|.:.....|...:.:|.:     ||.:|:..:.||....:...|
Mouse   698 HFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSR-----LHMILKPFMLRRIKKDVENEL 757

  Fly   724 PPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQD-----------LRRIWT 777
            ..|.|.:.|..|:..|:.|   |.....:.|..|::.......|..|:           .|::..
Mouse   758 SDKIEILTYCQLTSRQKLL---YQALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCN 819

  Fly   778 HPM----------------------------NLRV--NSDNVIAKRLLS---------------- 796
            ||.                            .:||  :|.:...|.|||                
Mouse   820 HPELFERQETWSPFHISLKPYEISKFIYRHGQIRVFNHSRDRWLKVLLSPFAPDYIQQSLFHRKG 884

  Fly   797 -NDDS------------------DMEGFIC------------------------DETDEDEAASN 818
             |:.|                  .::|.:.                        |.|.......|
Mouse   885 INEGSCFSFLRFIDVSPAEMANLMLQGLLARWLALFLSLKASYRLHQLRSWAEPDGTSHQSYLRN 949

  Fly   819 SS--------------DSCETFKSDASMSGLAASSG----KVKKRKTRNGN-------------- 851
            ..              .||...||....|...|.||    .|.:|::...:              
Mouse   950 KDFLLGVDFPLSFPNLCSCPLLKSLVFSSHCKAVSGYSDHVVHQRRSATSSLRCCLLTELPSFLC 1014

  Fly   852 ---------------------------AGGGDSDSDLEMLGG-------------------LGGG 870
                                       ..||...:...:|.|                   .||.
Mouse  1015 VASPRVTAVPLDSYCNDRSAEYERGVLKEGGSLAAKQCLLNGAPELATDWLSRRSQFFPEPAGGL 1079

  Fly   871 SSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLS 935
            .|::   |...|.......:.:.:..|.||..|..||.:.::.|.::|::||..:.:|::|.:: 
Mouse  1080 LSIR---PQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYM- 1140

  Fly   936 LVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAG 1000
            :...:|                     |.|||||..:.:|..|...|....::  .:||:|||||
Mouse  1141 VYRKHT---------------------YMRLDGSSKISERRDMVADFQTRNDI--FVFLLSTRAG 1182

  Fly  1001 GLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQAT 1065
            ||||||.||:.|:.:|..|||:.|.|::.|.:|.||.|...:||||..||:|:::.:|       
Mouse  1183 GLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQR------- 1240

  Fly  1066 AKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLIFKYH-EHDSL 1129
            ||   ::.:|.|       |.:.....||.|     :.||:  ...:|.:.|:|..|.. ..:..
Mouse  1241 AK---EKSEIQR-------MVISGGNFKPDT-----LKPKE--VVSLLLDDEELEKKLRLRQEEK 1288

  Fly  1130 LEQEEHENLTEEERKSAWAEYEAEKTR 1156
            .:|||...:.|.:||   .|..|||.:
Mouse  1289 RQQEESNRVKERKRK---REKYAEKKK 1312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 71/378 (19%)
HepA <382..1071 CDD:440319 197/878 (22%)
DEXHc_ATRX 455..699 CDD:350826 70/250 (28%)
Ino80NP_080850.2 Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000250|UniProtKB:Q9ULG1 1..268 55/231 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..88 10/43 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..250 11/37 (30%)
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000250|UniProtKB:Q9ULG1 214..528 67/334 (20%)
HepA 300..>832 CDD:440319 134/592 (23%)
DEXQc_INO80 520..748 CDD:350760 73/265 (28%)
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000250|UniProtKB:Q9ULG1 523..1559 201/885 (23%)
SF2_C_SNF 1093..1228 CDD:350180 51/158 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1285..1319 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1391..1464
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1504..1559
Blue background indicates that the domain is not in the aligned region.

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