DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment XNP and Chd8

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_963999.2 Gene:Chd8 / 67772 MGIID:1915022 Length:2582 Species:Mus musculus


Alignment Length:1403 Identity:298/1403 - (21%)
Similarity:517/1403 - (36%) Gaps:401/1403 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 NPNARHTDAATPLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNV---KASGKA 66
            ||.|    |..||....:.:|:.::.||...:....:.:|..|:.       |::|   ...||.
Mouse   261 NPGA----AGPPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQG-------HRHVVLGSLPGKI 314

  Fly    67 TVSSSSDSDQAVANSSANDEE-------------KEPVCKIRIVPLEKLLASPKTKERPSRGSQQ 118
            .:    ..:|..|.:.|.:.:             ::|..||:||| :...:.|:.:.:|...:|.
Mouse   315 VL----QGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQKIQIVP-QPPSSQPQPQPQPPPSAQP 374

  Fly   119 KNVTINDSSDEEPL-----KGSKLVLPAR----------KSRNKNASIIELSDSEEVDEEEESLL 168
              :|::.....:.:     .|.:|.:|.:          :..:...|::::..:.||........
Mouse   375 --LTLSSVQQAQIMGPGQNPGQRLSVPLKMVLQPQAGSSQGASSGLSVVKVLSASEVAALSSPAS 437

  Fly   169 VAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARA----------------IRSVNG 217
            .|   |..|.:|..|:|   ...|..:|::||.:....:.|||                :.||..
Mouse   438 CA---PHTAGKTGMEEN---RRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRP 496

  Fly   218 TRRGSLSSERSSRASSSRAESPPRPKRC----------------VVRLKRV-------SLPKTKP 259
            ...|.....:.|.....:.|.|.:.|..                ||..||.       |..:..|
Mouse   497 EEEGEKKRRKKSSGERLKEEKPKKSKTAAASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMP 561

  Fly   260 AQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEE------EAA 318
            ||.|::   |.|.:....:.:||.:.|..:|   |.:....::|||||...:|..:      |..
Mouse   562 AQSPRE---DEESSIQKRRSNRQVKRKKYTE---DLDIKITDDEEEEEVDVTGPIKPEPILPEPV 620

  Fly   319 NSSDSEVMPQRK-RRRKKSESDKGSSD----FEPEEKQKKKGR--------KRIKKTSSGESDGD 370
            ...|.|.:|..: .....||.|....|    ....:|:...|:        .:.|..|....:..
Mouse   621 QEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRVVKKELPSGQYTEAEEFFVKYKNYSYLHCEWA 685

  Fly   371 GDDDKQKNKRKHIR-KIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVE------ 428
            .....:|:||.|.: |..|||...:.......||......:|     .:||..:|.||:      
Mouse   686 TISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVE-----VDRILDESHSVDKDNGEP 745

  Fly   429 -INELV----LDFDEESKKALLQVDKGLLKKLK--------------PHQVAGVKFMWDACFETL 474
             |..||    |.:::.:.:....||:|.:::.|              |...|..|......::..
Mouse   746 VIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELRRVNRPQANAWKKLELSHEYKNR 810

  Fly   475 KESQEKPGSG-------------CILAHCMGLGKTLQVVTLSHTLLVNTRRTGV-DRVLIISPLS 525
            .:.:|....|             ||||..||||||:|    |...|......|: ...|:|:|||
Mouse   811 NQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQ----SIAFLQEVYNVGIHGPFLVIAPLS 871

  Fly   526 TVNNWAREFTSWMK---------FANRNDIEVYDISRY-KDKPTRI----FKLNEWFNEGGVCIL 576
            |:.||.|||.:|.:         .|:|..|:.|::  | ||...|:    :|.:       ..|.
Mouse   872 TITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEM--YCKDSRGRLIPGAYKFD-------ALIT 927

  Fly   577 GYDMYRILANEKAKGLRKKQREQLMQALVDPGPDL-------VVCDEGHLLKNEKTSISKAVTRM 634
            .::|                       ::...|:|       |:.||.|.|||....:..::..|
Mouse   928 TFEM-----------------------ILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHM 969

  Fly   635 RTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHR 699
            ..:.:::||||||||.:.|.:.::.|::|:...:..|::..|.:..|..|...            
Mouse   970 DLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQK------------ 1022

  Fly   700 SHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGA- 763
               |..:|:..:.||....:...|.||.|.::...|:.:|:|.|...:     :.....:.||| 
Mouse  1023 ---LQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAIL-----EKNFSFLSKGAG 1079

  Fly   764 -----RLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSC 823
                 .|.....:||:...||..:....:.::           ||               ..::|
Mouse  1080 HTNMPNLLNTMMELRKCCNHPYLINGAEEKIL-----------ME---------------FREAC 1118

  Fly   824 ETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEE 888
            .....|..:..:..|:|                                                
Mouse  1119 HIIPQDFHLQAMVRSAG------------------------------------------------ 1135

  Fly   889 RELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDF 953
                      ||:::.:||.:.:|.|.|:|:|||.::.||::|.:|.     .:.|.:|      
Mouse  1136 ----------KLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLI-----QRRYLYE------ 1179

  Fly   954 KGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVS 1018
                       |:||......|:|...:|:...:.|. :||:.||||||||||.||:..:|||..
Mouse  1180 -----------RIDGRVRGNLRQAAIDRFSKPDSDRF-VFLLCTRAGGLGINLTAADTCIIFDSD 1232

  Fly  1019 WNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTD 1083
            |||.:|.|:..|.:|.||.|...:||||...:.|::::::...|....|.|: :....|..|.|.
Mouse  1233 WNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVL-QSMSGRDGNITG 1296

  Fly  1084 LMELYSYELKPSTEREMPILPKDRLFAEILTE-HEKLIFKYHEHDSLLEQEEHENLTEEERKS-- 1145
            :.:.        :::|:..|.:...:|.|:.| .|...|...:.|.:|.:.......|.|.|.  
Mouse  1297 IQQF--------SKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRRTTTITIESEGKGST 1353

  Fly  1146 -AWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISK 1209
             |.|.:.|.:.||     .:|.|...|..:                 :..::|:.:.|||.|   
Mouse  1354 FAKASFVASENRT-----DISLDDPNFWQK-----------------WAKKADLDMDLLNSK--- 1393

  Fly  1210 DHQELNQNQVIQLVPTYLQQL--YNEMNNGDPTMYKDL 1245
                   |.::...|...:|.  ::.:.:.|...:.||
Mouse  1394 -------NNLVIDTPRVRKQTRHFSTLKDDDLVEFSDL 1424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 78/370 (21%)
HepA <382..1071 CDD:440319 173/755 (23%)
DEXHc_ATRX 455..699 CDD:350826 68/292 (23%)
Chd8NP_963999.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..111
SP1-4_N 61..>421 CDD:425404 32/177 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..155
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..377 8/30 (27%)
PTZ00121 <449..624 CDD:173412 39/183 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..585 20/112 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..617 6/18 (33%)
CD1_tandem_CHD5-9_like 640..705 CDD:349315 12/64 (19%)
CD2_tandem_CHD5-9_like 723..781 CDD:349310 14/62 (23%)
PLN03142 812..>1411 CDD:215601 180/802 (22%)
DEAD-like_helicase_N 813..1034 CDD:475120 66/271 (24%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 950..953 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1694..1715
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 1791..2304
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1990..2019
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2045..2120
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2187..2233
BRK 2311..2354 CDD:462196
BRK 2381..2420 CDD:470653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2486..2582
Blue background indicates that the domain is not in the aligned region.

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