DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment XNP and SMARCA4

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_001122321.1 Gene:SMARCA4 / 6597 HGNCID:11100 Length:1679 Species:Homo sapiens


Alignment Length:1319 Identity:296/1319 - (22%)
Similarity:455/1319 - (34%) Gaps:408/1319 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PNARHTDAATPLTTDDS--NSSSVSRRESATESKSASESESSPPRSNT---------------KQ 53
            |.....:||.|.:|...  ......|...|..:...:.|...||::.:               ||
Human   285 PEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQ 349

  Fly    54 SRTHKNVKASG--------------KATVSSSSDSDQAVANSSAND------------------- 85
            ||.....|..|              :|.::......:.:..|.|.|                   
Human   350 SRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQR 414

  Fly    86 --EEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKN 148
              .::..||..|...||..|.:...|....:..::..:|       |.|:..:.:...||.|.|:
Human   415 QLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARIT-------EKLEKQQKIEQERKRRQKH 472

  Fly   149 ASIIE--LSDSEEVDEEEESLLVAIPLPKEAQQT--KPEKNSSKASKESIEKR------------ 197
            ...:.  |..:::..|...|:...|....:|..|  ...:...|...|.|||.            
Human   473 QEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEG 537

  Fly   198 ------QKAQK-------EATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRL 249
                  ||..|       :.....|.....|...:...::.|:..:....:||:.......:.  
Human   538 YRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIG-- 600

  Fly   250 KRVSLPKTKPAQKPKKMS----------SDSEEAATTSKKSRQRRSKSESEAD------SDYEAP 298
                 |..:|..:..:||          |......|.:.|:.|..:..|....      ||.|..
Human   601 -----PDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEES 660

  Fly   299 AAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTS 363
            .:|||||||      |||...::....:|                   .|||:|           
Human   661 GSEEEEEEE------EEEQPQAAQPPTLP-------------------VEEKKK----------- 689

  Fly   364 SGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDR-----QKLYNRIFVK 423
              ..|.|.||..:.:.|..|              |.||::.|....:...     |..|......
Human   690 --IPDPDSDDVSEVDARHII--------------ENAKQDVDDEYGVSQALARGLQSYYAVAHAV 738

  Fly   424 SESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILA 488
            :|.|:            |::.|.|: |:||:   :|:.|::::.......|..         |||
Human   739 TERVD------------KQSALMVN-GVLKQ---YQIKGLEWLVSLYNNNLNG---------ILA 778

  Fly   489 HCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISR 553
            ..||||||:|.:.|...|:.:.|..|  ..|||.||||::|||.||..|..       .|..:| 
Human   779 DEMGLGKTIQTIALITYLMEHKRING--PFLIIVPLSTLSNWAYEFDKWAP-------SVVKVS- 833

  Fly   554 YKDKPT--RIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDE 616
            ||..|.  |.|.......:..|.:..|: |.|    |.|.:..|.|.:.|           :.||
Human   834 YKGSPAARRAFVPQLRSGKFNVLLTTYE-YII----KDKHILAKIRWKYM-----------IVDE 882

  Fly   617 GHLLKNEKTSISKAV-TRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLL---GTYKEYMNRFV 677
            ||.:||....:::.: |.....||::||||||||.|.|.:.::.|:.|.:.   .|::::.|.  
Human   883 GHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNA-- 945

  Fly   678 NPIT-NGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQK 741
             |.. .|:..|..|.:..|:..|   |||:|...:.||....:...||.|.|||:...:|.||:.
Human   946 -PFAMTGEKVDLNEEETILIIRR---LHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRV 1006

  Fly   742 LY------GYYMTTHREQSGGDVVGKGA--RLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSND 798
            ||      |..:|...|:   |..|||.  .|......||:|..||                   
Human  1007 LYRHMQAKGVLLTDGSEK---DKKGKGGTKTLMNTIMQLRKICNHP------------------- 1049

  Fly   799 DSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEM 863
                  ::....:|                                              |..|.
Human  1050 ------YMFQHIEE----------------------------------------------SFSEH 1062

  Fly   864 LGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLD 928
            ||..||               .|:..:|...  |.|..:|.|:|.:..|...|:|:|.|....:.
Human  1063 LGFTGG---------------IVQGLDLYRA--SGKFELLDRILPKLRATNHKVLLFCQMTSLMT 1110

  Fly   929 VIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLF 993
            ::|.:          :.:.|    ||        |.||||:...|.|..:.|.||. ......:|
Human  1111 IMEDY----------FAYRG----FK--------YLRLDGTTKAEDRGMLLKTFNE-PGSEYFIF 1152

  Fly   994 LISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYER 1058
            |:||||||||:||.:|:.|:|||..|||..|.|:..|.:|.||.....:.||..:.::|:|:...
Human  1153 LLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAA 1217

  Fly  1059 QVAKQATAKRVID----EQQISRHYNQTDLMELYSYE--------------------------LK 1093
            ...|....::||.    :|:.|.|..:..|..:..:|                          :.
Human  1218 AKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVN 1282

  Fly  1094 PSTEREMPI-----LPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHEN------LTEEERKSAW 1147
            |..| |.|:     :|.|....:::..||:....:...|....:||..|      |.||:...:|
Human  1283 PDLE-EPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSW 1346

  Fly  1148 ------------AEYEAEK 1154
                        .|.|.||
Human  1347 IIKDDAEVERLTCEEEEEK 1365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 62/334 (19%)
HepA <382..1071 CDD:440319 185/708 (26%)
DEXHc_ATRX 455..699 CDD:350826 74/250 (30%)
SMARCA4NP_001122321.1 DEGH box 881..884 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1254..1299 6/45 (13%)
SnAC 1322..1389 CDD:464219 11/44 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1432..1492
Bromo_SNF2L2 1490..1596 CDD:99947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1596..1679
KIKL. /evidence=ECO:0000269|PubMed:29567837 1628..1631
Necessary for interaction with SS18L1/CREST. /evidence=ECO:0000250 1..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..177
Med15 42..>222 CDD:312941
QLQ 171..205 CDD:462622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..352 13/66 (20%)
Smc <364..>570 CDD:440809 34/212 (16%)
HSA 460..532 CDD:214727 15/71 (21%)
RNA-binding region which is sufficient for binding to lncRNA Evf2. /evidence=ECO:0000250|UniProtKB:Q3TKT4 462..728 60/324 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..610 5/39 (13%)
BRK 612..656 CDD:197800 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 647..699 22/89 (25%)
DEXHc_SMARCA4 731..981 CDD:350820 90/306 (29%)
PLN03142 750..>1232 CDD:215601 175/640 (27%)
Sufficient for interaction with DLX1. /evidence=ECO:0000250|UniProtKB:Q3TKT4 837..916 27/94 (29%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.