Protein Alignment XNP and HLTF

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_011511393.1
• Gene: HLTF / 6596
• HGNCID: 11099
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 1086
• Identity: 228/1086 - (20%)
• Similarity: 382/1086 - (35%)
• Gaps: 374/1086 - (34%)

  Fly   208 SARAIRSVNGTRRGSLSSERSSRAS-----------------SSRAESPP----------RPKRC 245
            :|..:.:|||.:.|.|..|.:...:                 ::.|.:.|          ..|..
Human    96 NAIKVNNVNGNQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAV 160

  Fly   246 VVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAP--AAEEEEEEER 308
            ..:||:... |..||  ||.:..:.|....:.:            |...|..|  ||.:...|:.
Human   161 SDQLKKHGF-KLGPA--PKTLGFNLESGWGSGR------------AGPSYSMPVHAAVQMTTEQL 210

  Fly   309 KSSGD-------------EEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEP------------- 347
            |:..|             |.|.|.:.::.::|.:|:......|.:.|.:..|
Human   211 KTEFDKLFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTI 275

  Fly   348 ---EEKQKKK-----------------------------GR----KRIKK--------------- 361
               .||.:.:                             ||    :|:||
Human   276 TNFSEKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMK 340

  Fly   362 ----TSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKR----IEDRQKLYN 418
                .:|.::||...|..:.:::..|..|.:.....::  |.:.....|||.    ||...
Human   341 LGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMS--ELSSSRPKRRKTAVQYIESSD---- 399

  Fly   419 RIFVKSESVEINELVLDFDEESKKALLQVD---KGLLKKLKPHQVAGVKFMWDAC-----FETLK 475
                 ||.:|.:||    .::.|..|..|.   ||..|......:..|.|   ||     ..|.|
Human   400 -----SEEIETSEL----PQKMKGKLKNVQSETKGRAKAGSSKVIEDVAF---ACALTSSVPTTK 452

  Fly   476 ESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDR----VLIISPLSTVNNWAREFTS 536
            :...|.|: |.:.                    .:::|.|:.    .|||.|||.::||..:|..
Human   453 KKMLKKGA-CAVE--------------------GSKKTDVEERPRTTLIICPLSVLSNWIDQFGQ 496

  Fly   537 WMKFANRNDIEV-----YDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANE-KAKG---- 591
            .:|    :|:.:     |...|.:: |..:.|.:          :....|.||.:: ..||
Human   497 HIK----SDVHLNFYVYYGPDRIRE-PALLSKQD----------IVLTTYNILTHDYGTKGDSPL 546

  Fly   592 -----LRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNL 651
                 ||                  |:.||||.::|.....:|||..:.::||.||||||:||:|
Human   547 HSIRWLR------------------VILDEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSL 593

  Fly   652 REYYCMIQFVKPNLLGTY--KEYMNRFV-NPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQR 713
            ::.:.::.|:|   |..:  :|:.:|.: .|:|.|.     |..||.       |..|::....|
Human   594 KDLWSLLSFLK---LKPFIDREWWHRTIQRPVTMGD-----EGGLRR-------LQSLIKNITLR 643

  Fly   714 RDYS-------VLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSG-----GDVVGKGARLF 766
            |..:       ||.  ||.:..::.:.|||:.::|:|.......|...|     |.|:...|.:.
Human   644 RTKTSKIKGKPVLE--LPERKVFIQHITLSDEERKIYQSVKNEGRATIGRYFNEGTVLAHYADVL 706

  Fly   767 QDFQDLRRIWTH------------PMNLRVNSD-------NVIAK-RLLSNDDSDMEGFICDET- 810
            .....||:|..|            |....:.:|       .:|.| :|:.:..||.|..||.::
Human   707 GLLLRLRQICCHTYLLTNAVSSNGPSAFSLGNDTPEELRKKLIRKMKLILSSGSDEECAICLDSL 771

  Fly   811 ----------------------DEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAG 853
                                  :|...|     .|...::|.....|.....:...|
Human   772 TVPVITHCAHVFCKPCICQVIQNEQPHA-----KCPLCRNDIHEDNLLECPPEELAR-------- 823

  Fly   854 GGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLL 918
              ||:...:|                ||    ....::|.:.|:     |..|.::...|  |.|
Human   824 --DSEKKSDM----------------EW----TSSSKINALMHA-----LTDLRKKNPNI--KSL 859

  Fly   919 VFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFN 983
            |.||       ...||||::...|               .||..:.|||||.:.::|....:.|.
Human   860 VVSQ-------FTTFLSLIEIPLK---------------ASGFVFTRLDGSMAQKKRVESIQCFQ 902

  Fly   984 NITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAM 1048
            |.......:.|:|.:|||:|:||.||:||.:.|.:|||:.:.|...|.:|.||.:...|.:.|..
Human   903 NTEAGSPTIMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVK 967

  Fly  1049 GTMEQKVYERQVAKQ-------ATAKRVIDEQQISRHYNQTDLMEL 1087
            .::|:.:.:.|..|:       .|.|...||.:.::......|::|
Human   968 DSVEENMLKIQNKKRELAAGAFGTKKPNADEMKQAKINEIRTLIDL 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	64/368 (17%)
		HepA	<382..1071	CDD:440319	179/784 (23%)
		DEXHc_ATRX	455..699	CDD:350826	64/270 (24%)
HLTF	XP_011511393.1	HIRAN	60..153	CDD:400928	9/56 (16%)
		DEXHc_HLTF1_SMARC3	240..644	CDD:350829	101/490 (21%)
		DEAD-like_helicase_N	283..>357	CDD:475120	8/73 (11%)
		HepA	<472..990	CDD:440319	147/631 (23%)
		RING-HC_HLTF	759..813	CDD:438172	9/58 (16%)