DRSC/TRiP Functional Genomics Resources

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Protein Alignment XNP and SMARCA2

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_003061.3 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens


Alignment Length:1300 Identity:291/1300 - (22%)
Similarity:468/1300 - (36%) Gaps:397/1300 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 RRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCK 93
            :::...:.:...:.:..||:..|:|.:.        .|.|:.:..|......|..:..:|.||  
Human   226 QQQQQQQQQQQQQPQQQPPQPQTQQQQQ--------PALVNYNRPSGPGPELSGPSTPQKLPV-- 280

  Fly    94 IRIVPLEKLLASPKTKERPS----RGSQQKNVTINDSSDEEPLKGSK---LVLPARKSRNKNASI 151
                        |....|||    ..:|.....:...|..:|..|..   |.|..::||......
Human   281 ------------PAPGGRPSPAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQK 333

  Fly   152 IELSDSEEVDEEEESLLVA-----------IP--LPKE--------------------------- 176
            .:..|..|:.:|.|..|.|           :|  ||.:                           
Human   334 PQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVA 398

  Fly   177 ----------AQQTKPEKNSSKAS------KESIEKRQKAQKE------------ATTSSARAIR 213
                      |..:|..|.|.:.:      .|.:||:||.::|            :....|:..:
Human   399 CMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFK 463

  Fly   214 SVNGTRRGSL------------SSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKM 266
            ..:.:..|.:            ::||..:..:.|.|..        |::|:.....:..:|....
Human   464 EYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKE--------RMRRLMAEDEEGYRKLIDQ 520

  Fly   267 SSD-------------------------SEEAATTSKKSRQRRSKSESEADSDYEA--PAAEEEE 304
            ..|                         ..:||...||.|:|:.|:|..|:....|  |..|..:
Human   521 KKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPID 585

  Fly   305 EEERKSS---------------GDEEEAANSSDS--------EVMPQRKRRRKKSESDKGSSDFE 346
            |..:.|.               |.|...|:..|:        ||.|       :|:|::..||:|
Human   586 ESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAP-------RSDSEESDSDYE 643

  Fly   347 PEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIE 411
            .|:::::..|:..::...      .|.:.::...|..::||:      |.|:...:|...:....
Human   644 EEDEEEESSRQETEEKIL------LDPNSEEVSEKDAKQIIE------TAKQDVDDEYSMQYSAR 696

  Fly   412 DRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKE 476
            ..|..|......||.|           |.:.|||     :...||.:|:.|:::|.......|..
Human   697 GSQSYYTVAHAISERV-----------EKQSALL-----INGTLKHYQLQGLEWMVSLYNNNLNG 745

  Fly   477 SQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFA 541
                     |||..||||||:|.:.|...|:.:.|..|  ..|||.||||::||..||..|..  
Human   746 ---------ILADEMGLGKTIQTIALITYLMEHKRLNG--PYLIIVPLSTLSNWTYEFDKWAP-- 797

  Fly   542 NRNDIEVYDISRYKDKPTRIFKLNEWFNEG--GVCILGYDMYRILANEKAKGLRKKQREQLMQAL 604
                 .|..|| ||..|.....|......|  .|.:..|: |.|    |.|.:..|.|.:.|   
Human   798 -----SVVKIS-YKGTPAMRRSLVPQLRSGKFNVLLTTYE-YII----KDKHILAKIRWKYM--- 848

  Fly   605 VDPGPDLVVCDEGHLLKNEKTSISKAV-TRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLL-- 666
                    :.||||.:||....:::.: |.....|||:||||||||.|.|.:.::.|:.|.:.  
Human   849 --------IVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKS 905

  Fly   667 -GTYKEYMNRFVNPIT-NGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEY 729
             .|::::.|.   |.. .|:..|..|.:..|:..|   |||:|...:.||....:...||.|.||
Human   906 CSTFEQWFNA---PFAMTGERVDLNEEETILIIRR---LHKVLRPFLLRRLKKEVESQLPEKVEY 964

  Fly   730 VVYTTLSELQQKLY------GYYMTTHREQSGGDVVGKGA--RLFQDFQDLRRIWTHPMNLRVNS 786
            |:...:|.||:.||      |..:|...|:   |..|||.  .|......||:|..||       
Human   965 VIKCDMSALQKILYRHMQAKGILLTDGSEK---DKKGKGGAKTLMNTIMQLRKICNHP------- 1019

  Fly   787 DNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGN 851
                              ::....:|..|                 ..|..|:|.:      || 
Human  1020 ------------------YMFQHIEESFA-----------------EHLGYSNGVI------NG- 1042

  Fly   852 AGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDK 916
                                       :|.::.            |.|..:|.|:|.:..|...:
Human  1043 ---------------------------AELYRA------------SGKFELLDRILPKLRATNHR 1068

  Fly   917 LLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQ 981
            :|:|.|....:.::|.:.:.     :|:.                 |.||||:...|.|.|:.|:
Human  1069 VLLFCQMTSLMTIMEDYFAF-----RNFL-----------------YLRLDGTTKSEDRAALLKK 1111

  Fly   982 FNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLI 1046
            ||. ...:..:||:||||||||:||.||:.|||||..|||..|.|:..|.:|.||.....:.||.
Human  1112 FNE-PGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLC 1175

  Fly  1047 AMGTMEQKVYERQVAKQATAKRVID----EQQISRHYNQTDLMELYSYELKPSTEREMPILPKDR 1107
            .:.::|:|:......|....::||.    :|:.|.|..:..|..:..:|.:...|.|   :|.|.
Human  1176 TVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDE---VPDDE 1237

  Fly  1108 LFAEILTEHEKLIFKYHEHDSLLEQEEHEN------LTEEERKSAW------------AEYEAEK 1154
            ...:::...|:....:...|....:|:..|      |.||:...:|            .|.|.||
Human  1238 TLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEK 1302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 68/403 (17%)
HepA <382..1071 CDD:440319 187/703 (27%)
DEXHc_ATRX 455..699 CDD:350826 78/250 (31%)
SMARCA2NP_003061.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
Atrophin-1 <46..>450 CDD:460830 42/245 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176
QLQ 173..207 CDD:462622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334 23/129 (18%)
HSA 436..508 CDD:214727 11/79 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592 13/40 (33%)
BRK 589..632 CDD:462196 8/49 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 11/57 (19%)
DEXHc_SMARCA2 701..951 CDD:350821 93/306 (30%)
PLN03142 720..>1202 CDD:215601 174/636 (27%)
DEGH box 851..854 2/2 (100%)
SnAC 1259..1326 CDD:464219 9/43 (21%)
Bromodomain 1333..>1419 CDD:445827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383
Bromo_SNF2L2 1382..1506 CDD:99947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590
Blue background indicates that the domain is not in the aligned region.

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