DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment XNP and CHD8

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_001164100.1 Gene:CHD8 / 57680 HGNCID:20153 Length:2581 Species:Homo sapiens


Alignment Length:1413 Identity:299/1413 - (21%)
Similarity:517/1413 - (36%) Gaps:423/1413 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 NPNARHTDAATPLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNV---KASGKA 66
            ||.|    ...||....:.:|:.::.||...:....:.:|..|:.       |::|   ...||.
Human   261 NPGA----TGPPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQG-------HRHVVLGSLPGKI 314

  Fly    67 TVSSSSDSDQAVANSSANDEE-------------KEPVCKIRIVPLEKLLASPKTKERPSRGSQQ 118
            .:    ..:|..|.:.|.:.:             ::|..||:|||     ..|.::.:|.:....
Human   315 VL----QGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQKIQIVP-----QPPSSQPQPQQPPST 370

  Fly   119 KNVTINDSSDEEPL-----KGSKLVLPAR----------KSRNKNASIIELSDSEEVDEEEESLL 168
            :.||::.....:.:     .|.:|.:|.:          :..:...|::::..:.||......  
Human   371 QPVTLSSVQQAQIMGPGQSPGQRLSVPVKVVLQPQAGSSQGASSGLSVVKVLSASEVAALSSP-- 433

  Fly   169 VAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARA-IRSVNGTRRGSLSSERSSRAS 232
             |...|....:|..|:|   ...|..:|::||.:....:.||| .|......|.....|..|...
Human   434 -ASSAPHSGGKTGMEEN---RRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRP 494

  Fly   233 SSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSR---------QRRSKSE 288
            ....|...|.|....|||.         :||||  |.:..|:.|..||:         ::|.::.
Human   495 EEEGEKKRRKKSAGERLKE---------EKPKK--SKTSGASKTKGKSKLNTITPVVGKKRKRNT 548

  Fly   289 SEADSDYEA-PAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQK 352
            |..:||.|. ||....|:||   |..::..:|.       |.||::...:.|...:|.|.||:..
Human   549 SSDNSDVEVMPAQSPREDEE---SSIQKRRSNR-------QVKRKKYTEDLDIKITDDEEEEEVD 603

  Fly   353 KKG---RKRIKKTSSGESDGDGDDDKQ---KNKRKHIRKII-KTKDLDLTTKE------------ 398
            ..|   .:.|......|.||:.....|   :|..:....|: |...:.:..||            
Human   604 VTGPIKPEPILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRIVKKELPSGQYTEAEEF 668

  Fly   399 --------------AAKEEDDRRKRIEDRQKLY-------------------------NRIFVKS 424
                          |...:.::.|||..:.|.:                         :||..:|
Human   669 FVKYKNYSYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDES 733

  Fly   425 ESVE-------INELV----LDFDEESKKALLQVDKGLLKKLK--------------PHQVAGVK 464
            .|::       |..||    |.:::.:.:....||:|.:::.|              |...|..|
Human   734 HSIDKDNGEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKK 798

  Fly   465 FMWDACFETLKESQEKPGSG-------------CILAHCMGLGKTLQVVTLSHTLLVNTRRTGV- 515
            ......::...:.:|....|             ||||..||||||:|    |...|......|: 
Human   799 LELSHEYKNRNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQ----SIAFLQEVYNVGIH 859

  Fly   516 DRVLIISPLSTVNNWAREFTSWMK---------FANRNDIEVYDISRY-KDKPTRI----FKLNE 566
            ...|:|:||||:.||.|||.:|.:         .|:|..|:.|::  | ||...|:    :|.: 
Human   860 GPFLVIAPLSTITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEM--YCKDSRGRLIPGAYKFD- 921

  Fly   567 WFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDL-------VVCDEGHLLKNEK 624
                  ..|..::|                       ::...|:|       |:.||.|.|||..
Human   922 ------ALITTFEM-----------------------ILSDCPELREIEWRCVIIDEAHRLKNRN 957

  Fly   625 TSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDST 689
            ..:..::..|..:.:::||||||||.:.|.:.::.|::|:...:..|::..|.:..|..|...  
Human   958 CKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQK-- 1020

  Fly   690 ERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQS 754
                         |..:|:..:.||....:...|.||.|.::...|:.:|:|.|...:     :.
Human  1021 -------------LQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAIL-----EK 1067

  Fly   755 GGDVVGKGA------RLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDED 813
            ....:.|||      .|.....:||:...||              .|.|.            .|:
Human  1068 NFSFLSKGAGHTNMPNLLNTMMELRKCCNHP--------------YLING------------AEE 1106

  Fly   814 EAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDP 878
            :..:...::|.....|..:..:..|:|                                      
Human  1107 KILTEFREACHIIPHDFHLQAMVRSAG-------------------------------------- 1133

  Fly   879 SEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKN 943
                                ||:::.:||.:.:|.|.|:|:|||.::.||::|.:|.     .:.
Human  1134 --------------------KLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLI-----QRR 1173

  Fly   944 YEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVA 1008
            |.:|                 |:||......|:|...:|:...:.|. :||:.||||||||||.|
Human  1174 YLYE-----------------RIDGRVRGNLRQAAIDRFSKPDSDRF-VFLLCTRAGGLGINLTA 1220

  Fly  1009 ANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQ 1073
            |:..:|||..|||.:|.|:..|.:|.||.|...:||||...:.|::::::...|....|.|: :.
Human  1221 ADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVL-QS 1284

  Fly  1074 QISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTE-HEKLIFKYHEHDSLLEQEEHEN 1137
            ...|..|.|.:.:.        :::|:..|.:...:|.|:.| .|...|...:.|.:|.:.....
Human  1285 MSGRDGNITGIQQF--------SKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRRTTTI 1341

  Fly  1138 LTEEERKS---AWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDIL 1199
            ..|.|.|.   |.|.:.|.:.||     .:|.|...|..:                 :..::|:.
Human  1342 TIESEGKGSTFAKASFVASENRT-----DISLDDPNFWQK-----------------WAKKADLD 1384

  Fly  1200 LQLLNMKISKDHQELNQNQVIQLVPTYLQQL--YNEMNNGDPTMYKDL 1245
            :.|||.|          |.::...|...:|.  ::.:.:.|...:.||
Human  1385 MDLLNSK----------NNLVIDTPRVRKQTRHFSTLKDDDLVEFSDL 1422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 79/380 (21%)
HepA <382..1071 CDD:440319 174/806 (22%)
DEXHc_ATRX 455..699 CDD:350826 68/292 (23%)
CHD8NP_001164100.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..114
PHA03247 <68..280 CDD:223021 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..392 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..582 44/179 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..615 5/18 (28%)
CD1_tandem_CHD5-9_like 638..703 CDD:349315 9/64 (14%)
CD2_tandem_CHD5-9_like 721..779 CDD:349310 12/57 (21%)
PLN03142 810..>1409 CDD:215601 181/802 (23%)
DEXHc_CHD8 811..1032 CDD:350818 66/271 (24%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 948..951 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1692..1712
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124 1789..2302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2189..2229
BRK 2310..2354 CDD:197800
BRK 2379..2419 CDD:197800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2481..2581
Blue background indicates that the domain is not in the aligned region.

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