Protein Alignment XNP and SMARCAD1

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001121901.1
• Gene: SMARCAD1 / 56916
• HGNCID: 18398
• Length: 1028
• Species: Homo sapiens
• Alignment Length: 1223
• Identity: 270/1223 - (22%)
• Similarity: 462/1223 - (37%)
• Gaps: 325/1223 - (26%)

  Fly     3 KKNPNARHTDAATPLTTDDSNSSSVSRRESATESKSASE-SESSPPRSNTKQSRTHKNV------ 60
            :|.........|||..:....||.:|.  ||.|..:..| |.::.|.|:..:.....:|
Human    12 EKRNKIEEAPEATPQPSQPGPSSPISL--SAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDN 74

  Fly    61 --KAS--------GKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRG 115
              |||        |...:..||||:..|:.:.:|..:::...|..::.:.:.....:::..|:..
Human    75 ERKASISYFKNQRGIQYIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMA 139

  Fly   116 SQQKNVT-INDSSDEEPLKGSKL-----VLPARKSRNKNASIIE--------------------- 153
            .:..::: :.|.|:.|.||.:||     :.|.| |.|....:||
Human   140 RRNDDISELEDLSELEDLKDAKLQTLKELFPQR-SDNDLLKLIESTSTMDGAIAAALLMFGDAGG 203

  Fly   154 ------LSDSEEVDEEEESLLVAIPLPKEAQQTK-------PEKNSSKASKESIEKRQ----KAQ 201
                  ||.|.|..||:|.        .:.|..|       .|.|.|..|..:.||::    |.|
Human   204 GPRKRKLSSSSEPYEEDEF--------NDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQ 260

  Fly   202 KEATTSSARAIRSV---------------------NGTRRGSLSSERSSRASSSRAESPPRPKRC 245
            ||......:.:|.|                     ...:..|.|...:.:..|||:::.|:
Human   261 KEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPK---- 321

  Fly   246 VVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKS 310
                   :..|||..|   |.|..::......:|......|...| ||:|::.:......:|..|
Human   322 -------NATKTKLKQ---KFSMKAQNGFNKKRKKNVFNPKRVVE-DSEYDSGSDVGSSLDEDYS 375

  Fly   311 SGDEEEAANSSDSEVMP---QRKRRRKKSESDKGSSDFEPEEKQKKKGR-KRIKKTSSGESDGDG 371
            ||:          |||.   :.|......::..|.....|:..|||..: ..::..:|.|:
Human   376 SGE----------EVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEA---- 426

  Fly   372 DDDKQKNKRKHIRKIIKT----KDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINEL 432
                      ...|:.||    :||....|...:|.|           :..|:..|.|.:. |:|
Human   427 ----------LFTKMSKTNGLSEDLIWHCKTLIQERD-----------VVIRLMNKCEDIS-NKL 469

  Fly   433 VLDFDEESKKALLQVDKG---------LLKK---LKPHQVAGVKFMWDACFETLKESQEKPGSGC 485
                   :|:..:....|         :|.:   |||:|..|:.  |.|..       .|.|...
Human   470 -------TKQVTMLTGNGGGWNIEQPSILNQSLSLKPYQKVGLN--WLALV-------HKHGLNG 518

  Fly   486 ILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYD 550
            |||..||||||:|.:... ..|......|..  ||:.|.||::||.||...|.....   :..|.
Human   519 ILADEMGLGKTIQAIAFL-AYLYQEGNNGPH--LIVVPASTIDNWLREVNLWCPTLK---VLCYY 577

  Fly   551 ISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCD 615
            .|:.:.|..| |.::..:.:..|.:..|:.....:::::...|.|.             :..:.|
Human   578 GSQEERKQIR-FNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKL-------------NYAIFD 628

  Fly   616 EGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPI 680
            |||:|||..:...:.:..:....|::|||||:||||.|...::.||.|::..:....:.|..:..
Human   629 EGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSK 693

  Fly   681 TNGQYTDSTERDLRLMKHRSHILH--KLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLY 743
            |.       ..|.:.:..:..|.|  ::::..|.||....:...||||.:.:....:||.|::||
Human   694 TK-------SADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLY 751

  Fly   744 GYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICD 808
            .......::.....|..|...:......||::..||:   ::.....|::|     .:|...:..
Human   752 LGLFNRLKKSINNLVTEKNTEMCNVMMQLRKMANHPL---LHRQYYTAEKL-----KEMSQLMLK 808

  Fly   809 ETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSV 873
            |....||           ..|.....:...                  :|.:|.:|
Human   809 EPTHCEA-----------NPDLIFEDMEVM------------------TDFELHVL--------- 835

  Fly   874 QKDDPSEWWKPFVEERELNN-------VHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIE 931
                       ..:.|.:||       :..|.|..:|..:|.:.:..||::::|||....||::|
Human   836 -----------CKQYRHINNFQLDMDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILE 889

  Fly   932 HFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLIS 996
            ..|       |:::..               |.||||...:.:|..:..:||  |::...:||:|
Human   890 VLL-------KHHQHR---------------YLRLDGKTQISERIHLIDEFN--TDMDIFVFLLS 930

  Fly   997 TRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVA 1061
            |:||||||||.:||.|::.|:..||.:|.|:..|.:|.||.|...:.:||:.||:|:.:.:
Human   931 TKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLK---- 991

  Fly  1062 KQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILT 1114
                    |::|::....:.|.:.|        ..|..||        |:|.|
Human   992 --------INQQKLKLEQDMTTVDE--------GDEGSMP--------ADIAT 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	66/338 (20%)
		HepA	<382..1071	CDD:440319	166/713 (23%)
		DEXHc_ATRX	455..699	CDD:350826	64/243 (26%)
SMARCAD1	NP_001121901.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		18/71 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..251		13/55 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..328		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..373		4/19 (21%)
		HepA	<496..999	CDD:440319	152/631 (24%)
		DEGH box	628..631		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	721..738		6/16 (38%)
		DEGD box	1007..1010		1/10 (10%)