Protein Alignment XNP and CHD7

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Alignment Length: 1314
• Identity: 285/1314 - (21%)
• Similarity: 479/1314 - (36%)
• Gaps: 426/1314 - (32%)

  Fly    81 SSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTIND---SSDEEPLKGSKLVLPAR 142
            |..|..:|.||.:..  |.|..|..|........|...:.|..:|   |.:::|.:        :
Human   543 SPQNTPQKVPVHQHS--PSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQ--------K 597

  Fly   143 KSRNKNASIIELSDSE---------EVDEEE---ESLLVAIPLPKEAQQTKPEKNSSKASKESIE 195
            |.:.||..|:....|:         .||.:|   .||       ..:|:.|.:|..|||.|:..|
Human   598 KKKKKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSL-------DGSQEEKKKKKRSKAKKDPKE 655

  Fly   196 ----KRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPK 256
                |.:|..||..|..|..|                          |..||.   :..:.:.||
Human   656 PKEPKEKKEPKEPKTPKAPKI--------------------------PKEPKE---KKAKTATPK 691

  Fly   257 TKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYE-----APAAEEEEE---EERKSSGD 313
            .|.::|......|||.:|.   |.:..:.|:|...:||.:     :|..||:|:   ::|:||
Human   692 PKSSKKSSNKKPDSEASAL---KKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSS-- 751

  Fly   314 EEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDD---- 374
                         .|.||:|...:.:...||.|.::.. ..||.....||..|.....|.:
Human   752 -------------RQVKRKRYTEDLEFKISDEEADDAD-AAGRDSPSNTSQSEQQESVDAEGPVV 802

  Fly   375 ----------KQKNKRKHI---RKIIKTKDLD-LTTKEAAKEEDDRRKRIEDRQKLY------NR 419
                      |||...:.:   ...:|.|:.. |..:.|:.|:.::.|||:.:.|.:      |:
Human   803 EKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDKRIQQKIKRFKAKQGQNK 867

  Fly   420 IFVKSES-------VEINELV----------------------LDFDEESKKALLQVDKGLLK-- 453
            ...:.|.       ||::.::                      |.:::.:.:....:|:..::
Human   868 FLSEIEDELFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEF 932

  Fly   454 ----------------------------------KLKPHQVAGVK---FMWDACFETLKESQEKP 481
                                              ||:.:|:.||.   |.|...
Human   933 EKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNM----------- 986

  Fly   482 GSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGV-DRVLIISPLSTVNNWAREFTSWMKF----- 540
             ..||||..||||||:|.:|..:.:.:.    |: ...|:|:||||:.||.|||.:|.:.
Human   987 -RNCILADEMGLGKTIQSITFLYEIYLK----GIHGPFLVIAPLSTIPNWEREFRTWTELNVVVY 1046

  Fly   541 ----ANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLM 601
                |:|..|::|:: .:||...|:.|.:            |..:.|:..              .
Human  1047 HGSQASRRTIQLYEM-YFKDPQGRVIKGS------------YKFHAIITT--------------F 1084

  Fly   602 QALVDPGPDL-------VVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQ 659
            :.::...|:|       ||.||.|.|||....:.:.:..|..:.:::||||||||.:.|.:.::.
Human  1085 EMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLH 1149

  Fly   660 FVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLP 724
            |::|:...:...:|..|.:..|..|...               |..:|:..:.||....:...|.
Human  1150 FLEPSRFPSETTFMQEFGDLKTEEQVQK---------------LQAILKPMMLRRLKEDVEKNLA 1199

  Fly   725 PKHEYVVYTTLSELQQKLYGYYMT---THREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNS 786
            ||.|.::...|:.:|:|.|...:.   |...:.||.  .....|.....:||:...||..:....
Human  1200 PKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQ--ANVPNLLNTMMELRKCCNHPYLINGAE 1262

  Fly   787 DNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGN 851
            :.::                                 |.||                  :|.|..
Human  1263 EKIL---------------------------------EEFK------------------ETHNAE 1276

  Fly   852 AGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDK 916
            :    .|..|:.:                             :..:.||:::.:||.:.:|.|.:
Human  1277 S----PDFQLQAM-----------------------------IQAAGKLVLIDKLLPKLKAGGHR 1308

  Fly   917 LLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQ 981
            :|:|||.::.||::|.:|.     .:.|.:|                 |:||......|:|...:
Human  1309 VLIFSQMVRCLDILEDYLI-----QRRYPYE-----------------RIDGRVRGNLRQAAIDR 1351

  Fly   982 FNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLI 1046
            |:...:.|. :||:.||||||||||.||:..:|||..|||.:|.|:..|.:|.||.|...|||||
Human  1352 FSKPDSDRF-VFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLI 1415

  Fly  1047 AMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTD-LMELYSYELKPSTEREMPILPKDRLFA 1110
            ...:.|::::::...|....|.|:  |.:|...|.|: :.:|...|::       .:|.|....|
Human  1416 TRNSYEREMFDKASLKLGLDKAVL--QSMSGRENATNGVQQLSKKEIE-------DLLRKGAYGA 1471

  Fly  1111 EILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGNQV 1175
            .:..|.|...|...:.|.:|.:..|....|.|.|.:
Human  1472 LMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGS----------------------------- 1507

  Fly  1176 MGQFGNASGSVTSNKIFGFRSDILLQLLNM------KISKDHQELN-QNQVIQLVPTYLQQ--LY 1231
              .|..||...:.|     |:||.|...|.      |...|...|| :|.::...|...:|  ||
Human  1508 --TFAKASFVASGN-----RTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLY 1565

  Fly  1232 NEMNNGDPTMYKDL 1245
            :.:...:...:.||
Human  1566 SAVKEDELMEFSDL 1579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	71/387 (18%)
		HepA	<382..1071	CDD:440319	169/786 (22%)
		DEXHc_ATRX	455..699	CDD:350826	67/263 (25%)
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830	10/36 (28%)
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	13/64 (20%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	4/56 (7%)
		PLN03142	967..>1566	CDD:215601	189/810 (23%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800