Protein Alignment XNP and hells

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001032178.1
• Gene: hells / 553328
• ZFINID: ZDB-GENE-030131-9923
• Length: 853
• Species: Danio rerio
• Alignment Length: 943
• Identity: 232/943 - (24%)
• Similarity: 403/943 - (42%)
• Gaps: 210/943 - (22%)

  Fly   263 PKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANS--SDSEV 325
            ||...|:..|..|..:.:.::....|.....:.|......|||.|:|.....|||..|  :||:.
Zfish    17 PKPNESEEPEGTTIEETTMEKSKHEEMVITKEMEEEEKNLEEEGEKKEREMMEEARQSRGNDSQE 81

  Fly   326 MPQRKRRRKKSESDKGSSDF-----EPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRK 385
            | :.||.:...|.....|.|     |.:::::|..::|::|.::.......|....|.:||. |.
Zfish    82 M-RFKRLQHLLEKSNIYSKFLLTKMEQQQQEEKLKKERLEKKAAVLKQKGSDKKTVKVERKK-RG 144

  Fly   386 IIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINEL----------VLDFDEES 440
            ....|..|:.|||....:..:.|..|:.|     ..||.|:.:|.:|          :.:...|:
Zfish   145 REDYKIADVMTKEEIMSKAKKPKMEEEAQ-----ASVKLEAEDIEKLSDTNSDIKGRLSETLREN 204

  Fly   441 KKALLQVDKGLLKKLKP--------------HQVAGV---KFMWDACFETLKESQEKPGSGCILA 488
            .|.:|..::.:..:..|              :||.|:   :.:|:            .|...|||
Zfish   205 SKQMLDPERTVNGQPVPAQQPQLFTGGVMRWYQVEGIEWLRMLWE------------NGINGILA 257

  Fly   489 HCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISR 553
            ..||||||:|.:  :|..::..::. :...|:::||||:.||..||   .:|.....:.:|. ..
Zfish   258 DEMGLGKTIQCI--AHIAMMVEKKV-LGPFLVVAPLSTLPNWISEF---KRFTPEVSVLLYH-GP 315

  Fly   554 YKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGH 618
            .|::...:.|:.:......:|.:....:.|...:: |.|::.....|            :.||||
Zfish   316 QKERLDLVKKIRQHQGSLRMCPVVVTSFEIAMRDR-KFLQRFHWNYL------------IVDEGH 367

  Fly   619 LLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRF-VNPIT- 681
            .:||....:.:.:..:.|..:::||||||||||.|.:.::.|:.|::....|.:.:.| ::.||
Zfish   368 RIKNLNCRLVQELKMLPTDNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDISTITS 432

  Fly   682 NGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYY 746
            :.:...:.||:..::    |:||.:|...:.||..|.:...:|||.|.|||..|:..|:   .:|
Zfish   433 DAENIVANEREQNIL----HMLHLILTPFLLRRLKSDVTLEVPPKKEIVVYAPLTNKQE---AFY 490

  Fly   747 MTTHREQSGGDVVGKG-ARLFQDFQD----------------LRRI--WTHPMNLRVNSDNVIAK 792
            |.         :|.|. |:|....:|                .|::  :|.|     |:|::
Zfish   491 MA---------IVNKTIAKLLGQEKDESAPAPLTPSGRPKRRSRKVVNYTEP-----NTDSM--- 538

  Fly   793 RLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKS-DASMSGLAASSGKVKKRKTRNG------ 850
                   .|:|.::.....|.::.::|:.....|.. ||.::....:...:.||...:.
Zfish   539 -------KDLEKYLEKVQQELDSQASSTPVVNVFMPVDAQVNLKLQNILMLLKRCCNHAYLIEYP 596

  Fly   851 -NAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIG 914
             :...||...|.::                              |..|.|.|||.|:|.:.:..|
Zfish   597 LDPTTGDFKIDEQL------------------------------VEASGKFLILDRMLPELKKRG 631

  Fly   915 DKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMC 979
            .|:|:|||....||::..:                      |:..|.:|.|||||.|...|:...
Zfish   632 HKVLIFSQMTSILDILMDY----------------------CYLRGYEYSRLDGSMSYADRDENM 674

  Fly   980 KQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYR 1044
            |:|:  ::....|||:|||||||||||.:|:.|:|||..|||..|.|:..|.:|.||.||..::|
Zfish   675 KKFS--SDPEVFLFLLSTRAGGLGINLTSADTVIIFDSDWNPQADLQAQDRCHRIGQTKPVVVHR 737

  Fly  1045 LIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLF 1109
            ||...|:::|:.||..||:...|.||       |.|:   .:....|||.|         |..|.
Zfish   738 LITANTIDEKILERASAKRKLEKMVI-------HKNK---FKGSKAELKQS---------KSCLD 783

  Fly  1110 AEILTEHEKLIFKYHEHDSLLEQEEHENLTEEE 1142
            .:.|.|    :.|..::|..::..:.:.:::::
Zfish   784 VDELVE----LLKSRDYDGAVKGTKGKVISDKD 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	50/227 (22%)
		HepA	<382..1071	CDD:440319	187/744 (25%)
		DEXHc_ATRX	455..699	CDD:350826	61/262 (23%)
hells	NP_001032178.1	nuclear localization signal	140..145		3/5 (60%)
		PLN03142	224..>813	CDD:215601	182/729 (25%)
		DEXHc_HELLS_SMARCA6	230..463	CDD:350767	66/268 (25%)
		conserved domain I	241..265		9/35 (26%)
		conserved domain Ia	285..294		5/8 (63%)
		conserved domain II	353..371		6/29 (21%)
		leucine zipper motif	389..410		11/20 (55%)
		conserved domain III	390..397		5/6 (83%)
		conserved domain IV	456..466		3/9 (33%)
		Shugoshin_C	518..>534	CDD:462207	3/20 (15%)
		conserved domain IVa	580..592		2/11 (18%)
		conserved domain IVb	631..642		6/10 (60%)
		conserved domain V	688..701		11/12 (92%)
		conserved domain VI	719..729		3/9 (33%)