back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and ercc6

DIOPT Version :10

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001361595.1	Gene:	ercc6 / 548810	XenbaseID:	XB-GENE-1007918	Length:	1371	Species:	Xenopus tropicalis

Alignment Length:	1359	Identity:	304/1359 - (22%)
Similarity:	528/1359 - (38%)	Gaps:	403/1359 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRG 115
            |.|:.|.|.:   |:..        .:|.....|.|::          |:|:.|..|..:....|
Frog   136 TPQAATCKEI---GRKL--------DSVKRQKHNKEQQ----------LKKIKAKQKRLKAVLGG 179

  Fly   116 SQQKNVTINDSSDEEPLKG--SKLVLPARKSRNKNASIIELSDSEEVDEEEESLL---------V 169
            ||:      :...||.|:|  .:.|||     |...|::..|.    |.|.|.|:         .
Frog   180 SQE------EPDIEEDLQGYHEEDVLP-----NSLGSMLMPSQ----DREWEDLIRTGQMTPFGT 229

  Fly   170 AIPLPKEAQQTKPEK----NSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSR 230
            .|| |||  :.:|.|    .||...|...::.|.|.:.....:.:.::     ::..|:...|..
Frog   230 KIP-PKE--ERRPRKLMLNESSDFEKYLADQAQMAVQRKRPQTPKKVK-----KKTLLTKSPSLV 286

  Fly   231 ASSSRAESPPRPKRCVVRLK-----------RVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRR 284
            .|..:.::....|:...:::           ||.:|..||...||....:.:|:
Frog   287 PSVKKTDTSCTEKKLQKKMRKLQTKALQIQYRVGVPHAKPNLVPKNKIENGDES----------- 340

  Fly   285 SKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDS--EVMPQRKRRRKKSESDKG-SSDFE 346
                       |......|::||.....:||....|.|:  |:.|..:|...|...:.| ...|.
Frog   341 -----------EGSVYSPEKKEESMEENEEEWVPESQDTEYELKPLIQRTNGKRPRENGMDPGFL 394

  Fly   347 PEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIE 411
            |..::|:....|..|......||:....||:.::.|              |:..||:::|
Frog   395 PSSEEKEDHLSRSGKGQRCRDDGNAQLYKQRLRQWH--------------KQREKEKEER----- 440

  Fly   412 DRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDA-CFETLK 475
                      :.:|..|.::  ::|||.     ..:...:.|||..:|..||:::|:. |.:
Frog   441 ----------IATEESEDSD--VEFDEG-----FSIPCSIWKKLYKYQQTGVRWLWELHCQQ--- 485

  Fly   476 ESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRT--------GVDRVLIISPLSTVNNWAR 532
                   :|.||...||||||:|::.....|..:..||        |:...:|:.|.:.::.|.:
Frog   486 -------AGGILGDEMGLGKTIQIIAFLAGLSYSRIRTRGSDYRYEGLGPSIIVCPATVMHQWVK 543

  Fly   533 EF-TSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQ 596
            || |.|.:|   ..:.:::...|..|..::  :.|..|..|:.|..|...|::..|    |:|..
Frog   544 EFHTWWPQF---RVVILHETGSYAGKKVKL--IGELGNGCGILITSYSYVRLMQEE----LQKYH 599

  Fly   597 REQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFV 661
            ..            .::.||||.::|....::.|..:.||..||:|:|:|:||||||.:.:..||
Frog   600 WH------------YIILDEGHKIRNPNAGVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFV 652

  Fly   662 KPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRR---DYSV-LAPY 722
            .|..|||...:|.:|..|||.|.|::::...::.....:.:|...:...:.||   |..: ||
Frog   653 FPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLA-- 715

  Fly   723 LPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSD 787
            ||.|:|.|::..|::.|:::|..::.: :|..|  ::....::|.....||:|..||
Frog   716 LPDKNEQVLFCRLTDEQRQVYQTFIDS-KEVYG--ILNGEMQVFPGLIALRKICNHP-------- 769

  Fly   788 NVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNA 852
                                                          .|.:...|:.|
Frog   770 ----------------------------------------------DLFSGGPKILK-------- 780

  Fly   853 GGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKL 917
              |..|.|||            :::...:||            .|.||:::..||:.....|.::
Frog   781 --GTRDEDLE------------EEEQFGFWK------------RSGKLIVVEALLKIWHRQGHRV 819

  Fly   918 LVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQF 982
            |:|:||.|.|.::|.|:.                  ..|::    |.::||:.::..|:.:..::
Frog   820 LLFTQSRQMLQILEVFVR------------------SRCYS----YLKMDGTTTIASRQPLIAKY 862

  Fly   983 NNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIA 1047
            |...:|  .:||::||.||||:||..||||:|:|..||||.|||:..|.:|.||.|...:|||:.
Frog   863 NEDPSL--FVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLT 925

  Fly  1048 MGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPST---------------- 1096
            .||:|:|:|.||:.||....||:.:.:..|.:...||.||:::. .|.|
Frog   926 AGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTFS-SPDTSHGTETSAIFAGTGSD 989

  Fly  1097 -------------------EREMPI-------LPKDRLFAEILTEHEKLIF-------------- 1121
                               .:|.|:       ||...|.:.:....|..:.
Frog   990 VQVVKRPGNQNVAHTQTTFHKEPPVSISNTPSLPSKPLNSVLQHAQENPMLVGFEARSNSEVTPS 1054

  Fly  1122 --------KYHEHDSLLEQEE-----------HENLTEEERKSAWAEYEAEKT---------RTV 1158
                    |..:..||.|..|           |::..:..::...|:||.|:.         |..
Frog  1055 TSIKLESGKDCKQGSLTEAPENCHRKHKAKTKHQSKGKSVKRRKDAKYEGERISHLVKQNPFRRE 1119

  Fly  1159 QASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQELNQ--NQVIQ 1221
            :..|:  .||....:.|:.:....||..::.|     .|:::...|.......:|.::  ::.::
Frog  1120 EGDQH--EDRRKSDDYVLEKLFKKSGVHSAMK-----HDVIMDAANPDFVLVEEEASRVAHEALR 1177

  Fly  1222 LVPTYLQQLYNEMNNGDPTMYKDLLNLHSNIVHPS------GMYMNPLLYANQNPNAAG 1274
            ::....|:.| ..::|.||.      ...|.|.||      |...||||   |.|:..|
Frog  1178 VLKASRQRCY-AASSGVPTW------TGMNGVTPSGTKHRFGQKRNPLL---QTPDVPG 1226

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.