Protein Alignment XNP and ERCC6L

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_060139.2
• Gene: ERCC6L / 54821
• HGNCID: 20794
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 854
• Identity: 219/854 - (25%)
• Similarity: 365/854 - (42%)
• Gaps: 224/854 - (26%)

  Fly   382 HIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQ 446
            |..:.:|      ..|||.|..|     :|:..||:|    .::.:..||.||...::.::||.:
Human    20 HYLRYVK------EAKEATKNGD-----LEEAFKLFN----LAKDIFPNEKVLSRIQKIQEALEE 69

  Fly   447 V------------DKGLL------KKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGL 493
            :            :.|||      .:|..||..|:.|::     :|.....|.|   |||..|||
Human    70 LAEQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLY-----SLYRDGRKGG---ILADDMGL 126

  Fly   494 GKTLQVVT----LSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSW---MKFANRNDIEVYDI 551
            |||:|::.    :....|||       .||:|.|.:.:|.|.:||..|   |:      ::.:.
Human   127 GKTVQIIAFLSGMFDASLVN-------HVLLIMPTNLINTWVKEFIKWTPGMR------VKTFH- 177

  Fly   552 SRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDE 616
            ...||:.||  .||......||.|..|.|   |.|...:....:.:|.:.        |.|:.||
Human   178 GPSKDERTR--NLNRIQQRNGVIITTYQM---LINNWQQLSSFRGQEFVW--------DYVILDE 229

  Fly   617 GHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFV-KPNLLGTYKEYMNRFVNPI 680
            .|.:|...|..:.....:....|::|||||:||||:|.:.:..|. :.:||||.|.:...:.|||
Human   230 AHKIKTSSTKSAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPI 294

  Fly   681 TNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRR----------------------DYSVLA--P 721
            |..:..|:|..:..|....|..|..:::....||                      |...:.  |
Human   295 TRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMP 359

  Fly   722 YLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNS 786
            .|..|::.:::..|..||:::|..:::....:   :::.:......:...|:::..||
Human   360 SLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIK---ELLMETRSPLAELGVLKKLCDHP------- 414

  Fly   787 DNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGN 851
                  |||                       |:.:|       .:..|...|       .::||
Human   415 ------RLL-----------------------SARAC-------CLLNLGTFS-------AQDGN 436

  Fly   852 AGGGDSDSD-LEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGD 915
            .|....|.| ::.:          .||      ..:||        |.|::.|:.||::....|.
Human   437 EGEDSPDVDHIDQV----------TDD------TLMEE--------SGKMIFLMDLLKRLRDEGH 477

  Fly   916 KLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCS-VEQREAMC 979
            :.||||||.|.|::||..|       ||..|:               ..|:||:.: :.:||...
Human   478 QTLVFSQSRQILNIIERLL-------KNRHFK---------------TLRIDGTVTHLLEREKRI 520

  Fly   980 KQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYR 1044
            ..|..  |....:||::|:.||:|:.|.||.||||||.||||:.|.|::.||||.||.:...:||
Human   521 NLFQQ--NKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYR 583

  Fly  1045 LIAMGTMEQKVYERQVAKQATAKRVIDEQQIS-RHYNQTDLMELYSYE-LKPS-TEREMPILPKD 1106
            ||..||:|:|:|.|||.|.:..::...|::.. |::::.:|.||::.| |:.| |:.::..|...
Human   584 LITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAA 648

  Fly  1107 RLFAEI-LTEH----EKL-IFKYHEHDSL----LEQEEHENLTEE--------ERKSAWAEYEAE 1153
            :..::| |.||    :.| |....:||.:    |..:|..::.||        ::.....|:|::
Human   649 QRKSDIKLDEHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQ 713

  Fly  1154 KTRTVQASQ 1162
            ....:...|
Human   714 NKEFLMEQQ 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	22/95 (23%)
		HepA	<382..1071	CDD:440319	194/740 (26%)
		DEXHc_ATRX	455..699	CDD:350826	76/251 (30%)
ERCC6L	NP_060139.2	TPR 1	21..54		10/47 (21%)
		HepA	<90..610	CDD:440319	174/655 (27%)
		DEXHc_ERCC6L	96..328	CDD:350759	78/266 (29%)
		DEAH box	228..231		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..946
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1061..1092
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1110..1199
		TPR 2	1200..1233