DRSC/TRiP Functional Genomics Resources

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Protein Alignment XNP and INO80

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_060023.1 Gene:INO80 / 54617 HGNCID:26956 Length:1556 Species:Homo sapiens


Alignment Length:1396 Identity:304/1396 - (21%)
Similarity:511/1396 - (36%) Gaps:442/1396 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 SSSDSDQAVANSS-ANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGS--QQKNVTIND--SSDE 129
            ||.||:..:.:|: ...:..:|:.:::..|...||.     |....||  .....::|.  .|:.
Human    47 SSDDSEDGLDDSNPLLPQSGDPLIQVKEEPPNSLLG-----ETSGAGSSGMLNTYSLNGVLQSES 106

  Fly   130 EPLKG-----SKLVLPARKSRNKNASIIELSD--------SEEVDEEEESL-------LVAIPLP 174
            :..||     |||    :|||....||: |||        ||:.||||.:|       ::.:...
Human   107 KCDKGNLYNFSKL----KKSRKWLKSIL-LSDESSEADSQSEDDDEEELNLSREELHNMLRLHKY 166

  Fly   175 KEAQQTKPEKNSS----------------------------KASKESIEKRQKAQKEATTSSARA 211
            |:..|.|..|:..                            |..|...||:.||:.:......| 
Human   167 KKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEEKKLKAKLKKVKKKRR- 230

  Fly   212 IRSVNGTRRGSLSSERSSR---------ASSSRAESPPRPKRCVVRLKRVSLPKTK--------- 258
                   |...||||.|.|         |..|....||..|:..:.:::::..:.|         
Human   231 -------RDEELSSEESPRRHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKVWLSIVKKE 288

  Fly   259 -PAQKPKKMSSDSEEAATTSKKSRQ-----RRSKSESEADSDYEAPAA--------------EEE 303
             |....:|.|:.:.....:.|.:.|     ||:..:::.:.....|.|              |:.
Human   289 LPKANKQKASARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARRLTKEMLLYWKKYEKV 353

  Fly   304 EEEERKSSGDEEEAANSSDSEVMPQRKRRRK---------------KSESDKGSSDFEPEEKQKK 353
            |:|.||.:..|.......|.|:...::::||               ..:.|.|....:.|..:|.
Human   354 EKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRDMGHDGIQEEILRKL 418

  Fly   354 KGRKRIKKTSSG--------ESDGDGDDDKQ---KNKRK--HIRKIIKTKDLDLTTKEAAKEEDD 405
            :.....::...|        :.|.|.:..|.   ||...  ||.: .:|:..|    |.|||...
Human   419 EDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQ-ARTRSFD----EDAKESRA 478

  Fly   406 RRKRIEDRQ-----KLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKF 465
            ...|..::.     :.|:   :.:.|:...|   |..:.:      :..|   |||.:|:.|:.:
Human   479 AALRAANKSGTGFGESYS---LANPSIRAGE---DIPQPT------IFNG---KLKGYQLKGMNW 528

  Fly   466 MWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNW 530
            :     ..|.|.    |...|||..||||||:|.:.|...|.......|  ..|||||.||:|||
Human   529 L-----ANLYEQ----GINGILADEMGLGKTVQSIALLAHLAERENIWG--PFLIISPASTLNNW 582

  Fly   531 AREFTSWM-KF------ANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEK 588
            .:|||.:: ||      .|.:|.:|  |.|:..:.| ::..:..|:   |.|..|.:.       
Human   583 HQEFTRFVPKFKVLPYWGNPHDRKV--IRRFWSQKT-LYTQDAPFH---VVITSYQLV------- 634

  Fly   589 AKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLRE 653
            .:.::..||.:.         ..:|.||...||:..:...|.:.:.:.:.|::|||||:||.:.|
Human   635 VQDVKYFQRVKW---------QYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAE 690

  Fly   654 YYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSV 718
            .:.::.|:.|.|..:::|:...|...|.:.....|...:.:|.:     ||.:|:..:.||....
Human   691 LWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSR-----LHMILKPFMLRRIKKD 750

  Fly   719 LAPYLPPKHEYVVYTTLSELQQKLY---------------------------------------- 743
            :...|..|.|.::|..|:..|:.||                                        
Human   751 VENELSDKIEILMYCQLTSRQKLLYQALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKV 815

  Fly   744 ---------------------GYYMTT-----------------------------------HR- 751
                                 .|:::.                                   || 
Human   816 CNHPELFERQETWSPFHISLKPYHISKFIYRHGQIRVFNHSRDRWLRVLSPFAPDYIQRSLFHRK 880

  Fly   752 -------------------EQSGGDVVGKGARLFQDFQDLR--------RIWTHP---------- 779
                               |.:...:.|..||....|..|:        |.|..|          
Human   881 GINEESCFSFLRFIDISPAEMANLMLQGLLARWLALFLSLKASYRLHQLRSWGAPEGESHQRYLR 945

  Fly   780 -------MNLRVNSDNVIAKRLL-----SNDDSDMEGFICDETDEDEAASNSSDSC-----ETFK 827
                   :|..::..|:.:..||     |:....:.|:......:..:|::|...|     .:|.
Human   946 NKDFLLGVNFPLSFPNLCSCPLLKSLVFSSHCKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFL 1010

  Fly   828 SDASMSGLAA--------SSGKVKKRKTRNGNA---------GGGDSDSDL---------EMLGG 866
            ..||....|.        .|.:.::|..:.|.:         |..:..:|.         |..||
Human  1011 CVASPRVTAVPLDSYCNDRSAEYERRVLKEGGSLAAKQCLLNGAPELAADWLNRRSQFFPEPAGG 1075

  Fly   867 LGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIE 931
            |.   |::   |...|.......:.:.:..|.||..|..||.:.::.|.::|::||..:.:|::|
Human  1076 LW---SIR---PQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLE 1134

  Fly   932 HFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLIS 996
            .:: :...:|                     |.|||||..:.:|..|...|.|..::  .:||:|
Human  1135 EYM-VYRKHT---------------------YMRLDGSSKISERRDMVADFQNRNDI--FVFLLS 1175

  Fly   997 TRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVA 1061
            ||||||||||.||:.|:.:|..|||:.|.|::.|.:|.||.|...:||||..||:|:::.:|   
Human  1176 TRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQR--- 1237

  Fly  1062 KQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLIFKYH-E 1125
                ||   ::.:|.|       |.:.....||.|     :.||:  ...:|.:.|:|..|.. .
Human  1238 ----AK---EKSEIQR-------MVISGGNFKPDT-----LKPKE--VVSLLLDDEELEKKLRLR 1281

  Fly  1126 HDSLLEQEEHENLTEEERKSAWAEYEAEKTR 1156
            .:...:|||...:.|.:||   .|..|||.:
Human  1282 QEEKRQQEETNRVKERKRK---REKYAEKKK 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 70/385 (18%)
HepA <382..1071 CDD:440319 195/877 (22%)
DEXHc_ATRX 455..699 CDD:350826 70/250 (28%)
INO80NP_060023.1 Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000269|PubMed:21303910 1..266 57/236 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..87 10/44 (23%)
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000269|PubMed:21303910 212..526 65/341 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..249 10/37 (27%)
HepA 298..>830 CDD:440319 125/589 (21%)
DEXQc_INO80 518..746 CDD:350760 73/265 (28%)
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000269|PubMed:21303910 521..1556 200/884 (23%)
SF2_C_SNF 1090..1225 CDD:350180 52/158 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1316 10/30 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1388..1408
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1461
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1499..1556
Blue background indicates that the domain is not in the aligned region.

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