Protein Alignment XNP and smarca4

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001362194.1
• Gene: smarca4 / 496545
• XenbaseID: XB-GENE-483983
• Length: 1599
• Species: Xenopus tropicalis
• Alignment Length: 1150
• Identity: 277/1150 - (24%)
• Similarity: 430/1150 - (37%)
• Gaps: 326/1150 - (28%)

  Fly    91 VCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIE-- 153
            ||..|...||..|.:...|....:..::..:|       |.|:..:.:...||.|.|:...:.
 Frog   407 VCMRRDTALETALNAKAYKRSKRQSLREARIT-------EKLEKQQKIEQERKRRQKHQEYLNSI 464

  Fly   154 LSDSEEVDEEEESLLVAIPLPKEAQQT--KPEKNSSKASKESIEKR--QKAQKEATTSSARAIRS 214
            |..:::..|...|:...|....:|..|  ...:...|...|.|||.  ::...|......:.|..
 Frog   465 LQHAKDFKEFHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQ 529

  Fly   215 VNGTRRGSLSSE------------RSSRASSSRAESPPRPKRCVVRL---KRVSL-PKTKPAQKP 263
            ....|...|..:            |..:|..:..|...|.|:.|..:   ::.:| |..:|..:.
 Frog   530 KKDKRLAYLLQQTDEYVANLTELVRQHKAVQALKEKKRRKKKKVQEITEGQQSALGPDGEPLDET 594

  Fly   264 KKMSS--------DSEEAATTSKKSRQRRSKSESEADSDYE-APAAEEEEEEERKSSGDEEEAAN 319
            .:||.        :|.:..|.:...:..:.::..|.:..|| ||.::.||.|    |.||||
 Frog   595 SQMSDLPIKVIHVESGKILTGADAPKAGQLEAWLEMNPGYEVAPRSDTEESE----SEDEEE--- 652

  Fly   320 SSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIR 384
            ..|.:..|.........|:                  |:|       :|.|.||..:    .|.|
 Frog   653 EEDEQQQPSVTSLLAVDET------------------KKI-------ADPDSDDVSE----VHAR 688

  Fly   385 KIIKTKDLDLTTKEAAKEEDDRRKRIEDR-----------QKLYNRIFVKSESVEINELVLDFDE 438
            :||                |:.|:.::|.           |..|......||.|:
 Frog   689 EII----------------DNARQDVDDEYGISHAETSGLQSYYAVAHAVSEKVD---------- 727

  Fly   439 ESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLS 503
              |::.|.|: |:||:   :|:.|::::.......|..         |||..||||||:|.:.|.
 Frog   728 --KQSTLLVN-GILKQ---YQIKGLEWLVSLYNNNLNG---------ILADEMGLGKTIQTIALI 777

  Fly   504 HTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPT--RIF---- 562
            ..|:.:.|..|  ..|||.||||::||..||..|       ...|..:| ||..|.  |.|
 Frog   778 TYLMEHKRING--PFLIIVPLSTLSNWVYEFDKW-------GPSVVKVS-YKGSPAARRAFVPML 832

  Fly   563 ---KLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEK 624
               |.|       |.:..|: |.|    |.|.:..|.|.:.|           :.||||.:||..
 Frog   833 RSGKFN-------VLLTTYE-YII----KDKHILAKIRWKYM-----------IVDEGHRMKNHH 874

  Fly   625 TSISKAV-TRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLL---GTYKEYMNRFVNPIT-NGQ 684
            ..:::.: |.....||::||||||||.|.|.:.::.|:.|.:.   .|::::.|.   |.. .|:
 Frog   875 CKLTQVLNTHYVAPRRVLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNA---PFAMTGE 936

  Fly   685 YTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLY------ 743
            ..|..|.:..|:..|   |||:|...:.||....:...||.|.|||:...:|.||:.||
 Frog   937 KVDLNEEETILIIRR---LHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSSLQRVLYRHMQAK 998

  Fly   744 GYYMTTHREQSGGDVVGKGA--RLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFI 806
            |..:|...|:   |..|||.  .|......||:|..||                         ::
 Frog   999 GVLLTDGSEK---DKKGKGGTKTLMNTIMQLRKICNHP-------------------------YM 1035

  Fly   807 CDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGS 871
            ....:|                                              |..|.||..||
 Frog  1036 FQHIEE----------------------------------------------SFSEHLGFSGG-- 1052

  Fly   872 SVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSL 936
                         .|:..:|...  |.|..:|.|:|.:..|...|:|:|.|....:.::|.:
 Frog  1053 -------------IVQGADLYRA--SGKFELLDRILPKLRATQHKVLLFCQMTTLMTIMEDY--- 1099

  Fly   937 VDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGG 1001
                   :.:.|    ||        |.||||:...|.|..:.|.||. ::....:||:||||||
 Frog  1100 -------FAYRG----FK--------YLRLDGTTKAEDRGMLLKTFNE-SSSEYFIFLLSTRAGG 1144

  Fly  1002 LGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATA 1066
            ||:||.:|:.|:|||..|||..|.|:..|.:|.||.....:.||..:.::|:|:......|....
 Frog  1145 LGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVD 1209

  Fly  1067 KRVID----EQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLIFKYHEHD 1127
            ::||.    :|:.|.|..:..|..:..:|.:...|.|   :|.|....:::..||:....:...|
 Frog  1210 QKVIQAGMFDQKSSSHERKVFLQAILEHEEQDEEEDE---VPDDETVNQMIARHEEEFDLFMRMD 1271

  Fly  1128 SLLEQEEHEN------LTEEERKSAW------------AEYEAEK 1154
            ....:||..|      |.||:...:|            .|.|.||
 Frog  1272 LDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEK 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	64/326 (20%)
		HepA	<382..1071	CDD:440319	189/721 (26%)
		DEXHc_ATRX	455..699	CDD:350826	75/257 (29%)
smarca4	NP_001362194.1	Atrophin-1	<60..>459	CDD:460830	14/58 (24%)
		QLQ	164..198	CDD:462622
		Smc	<349..>591	CDD:440809	37/190 (19%)
		HSA	445..517	CDD:214727	15/71 (21%)
		BRK	596..639	CDD:462196	8/42 (19%)
		DEXHc_SMARCA4	715..965	CDD:350820	92/313 (29%)
		PLN03142	734..>1216	CDD:215601	176/647 (27%)
		SnAC	1273..1340	CDD:464219	10/43 (23%)
		Bromo_SNF2L2	1408..1515	CDD:99947