DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and dom

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster

Alignment Length:	1816	Identity:	361/1816 - (19%)
Similarity:	589/1816 - (32%)	Gaps:	743/1816 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVAN 80
            ||..:.|||:..:..:|...||..|.:||:|..:.:..|.|......||.|| |:|:.|.:|..|
  Fly   293 PLDGNISNSTVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGTATSGAAT-STSATSAEASGN 356

  Fly    81 SSANDEE---------------KEPVCKIRIV--------PL--------EKLLASPKTKERPS- 113
            ..|.:.|               |.|...:::.        ||        .::.|.|.....||
  Fly   357 VLAVEAEIKIPAVGATPVAISTKLPAAVVQLTQQGHIPGRPLGGRHGMVFGQIPAPPAAVGNPSV 421

  Fly   114 ----------------------RGSQQKNVTINDSSDE--------------------------- 129
                                  |...|.|.:...::..
  Fly   422 PLVPGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPAALGGSGGLT 486

  Fly   130 --EPLKGSKLVLPA----RKSRNKNASIIELSDSEEV-------DEEEESLLVAIPLPK------ 175
              .|..|| |:.||    ..:.|..|........:||       :.:.|.|.....|||
  Fly   487 PGTPTSGS-LLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSR 550

  Fly   176 ------------------EAQQTKPEKNSSKASKESIEK-----------RQKAQ----KEATTS 207
                              .||:.|.:||::|...:.::|           .:|||    |...:.
  Fly   551 PKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASF 615

  Fly   208 SARAIRS----------------VNGTRRGSL---------SSERSSR---------------AS 232
            .||.::|                :...|:.:|         .:|:.|:               .:
  Fly   616 IAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLN 680

  Fly   233 SSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKK------------------ 279
            |||..||.|......|.:..|....:...|.::.::|.:|..|...|
  Fly   681 SSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYL 745

  Fly   280 -SRQRRSKSESEA-----------DSDYEAPAA------------EEEEEEERKSSGDEEEAANS 320
             :|.:..|.|..:           ||::||..|            |.|:|.:.|...||.||.|.
  Fly   746 ENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADND 810

  Fly   321 SD---------SEVMPQRKRRR-----KKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDG 371
            ..         ||..|..|||:     .:.:||..|:..:..|:.:....:..:..|:.::|.|.
  Fly   811 LSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDM 875

  Fly   372 DD-DKQKNKRKHIRKIIKTKDLDLT--------TKEAAKEEDDRRKRIEDRQKLYNRIFVKSESV 427
            :: |:|::..|.:     ..|.|.|        |..|:..:||   .:.|...|...:..|..::
  Fly   876 EEQDEQEDGLKSL-----MADADATSGAAGSGSTAGASGNKDD---MLNDAAALAESLQPKGNTL 932

  Fly   428 EINELV--LDFDEESKKALLQVDKGLLK-KLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAH 489
            ....:|  :.|              ||| .|:.:|..|:.  |      |....|:..:| |||.
  Fly   933 SSTNVVTPVPF--------------LLKHSLREYQHIGLD--W------LVTMNERKLNG-ILAD 974

  Fly   490 CMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSW---MKFANRNDIEVYDI 551
            .||||||:|.:.|...|.......|..  ||:.|.|.:.||..||..|   .|.          :
  Fly   975 EMGLGKTIQTIALLAHLACAKGNWGPH--LIVVPSSVMLNWEMEFKKWCPGFKI----------L 1027

  Fly   552 SRYKDKPTRIFKLNEWF--NEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVC 614
            :.|..:..|..|...|.  |...|||..   |:::..::....|||.:             .::.
  Fly  1028 TYYGSQKERKLKRVGWTKPNAFHVCITS---YKLVVQDQQSFRRKKWK-------------YLIL 1076

  Fly   615 DEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNP 679
            ||...:||.|:...:.:....|:||::||||||||:|.|.:.::.|:.|.:..:::|:...|.||
  Fly  1077 DEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNP 1141

  Fly   680 ITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYG 744
            :| |....:.|.:..|:..    |||::...:.||....:...:|.|:|:|:...||..|:.||.
  Fly  1142 MT-GMIEGNMEYNETLITR----LHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYE 1201

  Fly   745 YYMT---THREQSGGDVVGKGARLFQDFQDLRRIWTHPMNL------------------------ 782
            .:|:   |......|:::.    :......||::..|| |:
  Fly  1202 DFMSRAKTRETLQTGNLLS----VINVLMQLRKVCNHP-NMFEARPTISPFQMDGITFHTPRLVC 1261

  Fly   783 ---------RVNSDNVIAKRLLSNDDSDMEGFICDET-----------DEDEA------------ 815
                     ::|.:.:  ..||.:.:..|..::..::           |.|.|
  Fly  1262 DIMEYDPFTQINLETL--NLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKY 1324

  Fly   816 ----ASNSSDSCETFKSDASMSGLAAS----------------SGKVKKR--------------- 845
                ...|::..:..|.:|...|.:.:                ||:|.||
  Fly  1325 RFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPV 1389

  Fly   846 ------------KTRNGNAGGGDSDSDLEMLG--------------------------------G 866
                        .|.:...|.....|:.::||                                |
  Fly  1390 VINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSG 1454

  Fly   867 LGGG---------------------------------------------SSVQK----------- 875
            ..|.                                             |:|||
  Fly  1455 AAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPE 1519

  Fly   876 -----DDP-------------------------------------------------------SE 880
                 :||                                                       |.
  Fly  1520 EETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRST 1584

  Fly   881 W-----------------W------KPFVEER----------------------------ELNNV 894
            |                 |      |.| |||                            .|::.
  Fly  1585 WQTRGYANCCTAMAHRNGWSLNHLLKSF-EERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSST 1648

  Fly   895 H--HS------------PKLLILL---------------------------RLLQQCEAIGDKLL 918
            |  |.            |||.:|.                           |||:|.:..|.::|
  Fly  1649 HWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVL 1713

  Fly   919 VFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFN 983
            :|:|..:.|||:|.||        ||.              |..|.|||||..||||:.:.::||
  Fly  1714 IFTQMTKMLDVLEAFL--------NYH--------------GHIYLRLDGSTRVEQRQILMERFN 1756

  Fly   984 NITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAM 1048
            .  :.|...|::|||:||:||||..|:.|:.:|..|||:.|.|:..|.:|.||.:..:||||::
  Fly  1757 G--DKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVS- 1818

  Fly  1049 GTMEQKVYERQVAKQATAKRVIDEQQI------SRHYNQTDLMELYSYELKPSTEREMPILP-KD 1106
                ::..|..:.|:|..||::.:..|      :.::..:.:.:|::.|.....|....... ||
  Fly  1819 ----ERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKD 1879

  Fly  1107 RLFA--------EILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQY 1163
            |:.|        ..:.|.||...:..|| :|...|:.:::  :..|:|.||.         |:..
  Fly  1880 RIVATTTLSDTPSTVVETEKQSLRAFEH-ALAAAEDEQDV--QATKTAKAEV---------AADL 1932

  Fly  1164 MSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQELNQNQVIQLVP 1224
            ..:|.|.   .:..:..||.|..                 .:::||...|: ||.|.||.|
  Fly  1933 AEFDENI---PIATEDPNAEGGP-----------------QVELSKADLEM-QNLVKQLSP 1972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	28/132 (21%)
		SNF2_N	458..779	CDD:278600	88/328 (27%)
		DEXDc	483..646	CDD:238005	47/167 (28%)
		Helicase_C	913..1035	CDD:278689	46/121 (38%)
dom	NP_001286676.1	HSA	543..614	CDD:214727	13/70 (19%)
		ASF1_hist_chap	<674..831	CDD:304562	34/156 (22%)
		FAM176	<824..>868	CDD:291517	8/43 (19%)
		SNF2_N	952..1238	CDD:278600	91/332 (27%)
		DEXDc	969..1108	CDD:238005	47/167 (28%)
		Helicase_C	1692..1806	CDD:278689	50/137 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467175
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840