DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and Ino80

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster

Alignment Length:	1641	Identity:	310/1641 - (18%)
Similarity:	562/1641 - (34%)	Gaps:	551/1641 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TDDSNSSSVSRRESATESKS---------------------------------ASESESSPP--- 47
            :|||::..|.|.:.:::.||                                 .|::||..|
  Fly    67 SDDSSTVGVVRMKQSSKRKSRLLASKEERQSVKAQLYNFNDLTSDREWLYDLLLSDTESDDPTIT 131

  Fly    48 ---------RSNTKQSRTHKN-VKASGKATVS-------SSSD--SDQAVANSSANDEEKEPVCK 93
                     |.:.::.|..|| .|.:..|..:       |:.|  :::.:|.:......:....:
  Fly   132 EDEYVQQLLREHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFAERQLATAGVRKRRRRTKQE 196

  Fly    94 IRIVPLEKLLASPKTKERPSRGSQQK-NVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDS 157
            |.:..|.:..|.||..::..||.::: |:...:|.:..|.:..|.........|::    :..|.
  Fly   197 ILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKYTFGDTLPNNED----DDEDG 257

  Fly   158 EEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGS 222
            .|||.:.|...:|:..|:| ::.:.|.:....::..:.|.::.:|.....:||..|...     .
  Fly   258 GEVDYKRELASLALDYPEE-EEIEEEVDVEGGTEGQVTKVRRKRKNPAALAARRRRIWQ-----I 316

  Fly   223 LSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKS 287
            :|.:.|.|....::.:   .|..:...|||                    |...:|..|||...|
  Fly   317 MSKKESGRLQRIKSNN---HKEMLANCKRV--------------------AGMCAKVVRQRAINS 358

  Fly   288 ES-EADSDYEAPAAEEE-----------EEEERKSSGDEEEAANSSDSEVMPQRKRRRK------ 334
            :. ..::.:.|.....|           |.::|:....|.|.....|.|::..::::||
  Fly   359 QRIMKETVWRAKRLTREMLAYWKRYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLIT 423

  Fly   335 ---------KSESDKGSSDFEPEEKQKKKGRKRIKKTS---SGESDGDGDDDK---QKNKRKHI- 383
                     ..:..:||     ||.|.:...:..::|:   :.:.|.|..:.|   |:|....:
  Fly   424 QTELYAHFMSKKLGQGS-----EEDQLRILSQLDEETNARLAAQDDYDAGEMKLLAQENAEAAMQ 483

  Fly   384 RKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVD 448
            |.:.||:..|:..|:..|||:::.:                ||||      |...|.:..:..:.
  Fly   484 RDLDKTRAFDVFAKKKEKEEEEQAQ----------------ESVE------DIKPEPRPEMKDLP 526

  Fly   449 KGLLKK--LKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQ-VVTLSHTLLVNT 510
            :..:.|  ||.:|:.|:  .|      |....::..|| |||..||||||:| :..|.|.    .
  Fly   527 QPKMFKGTLKGYQIKGM--TW------LANIYDQGISG-ILADEMGLGKTVQSIAFLCHI----A 578

  Fly   511 RRTGV-DRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEG--- 571
            ...|| ...|:|||.||::||.:|.:.:        :..:.:..|...|.....|.:::::.
  Fly   579 EHYGVWGPFLVISPASTLHNWQQEMSRF--------VPDFKVVPYWGSPAERKILRQFWDQKHLH 635

  Fly   572 ------GVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKA 630
                  .|.|..|.:  ::::.|.....|.|              .:|.||...:|:..:...|.
  Fly   636 TRDASFHVVITSYQL--VVSDYKYFNRIKWQ--------------YMVLDEAQAIKSAASQRWKL 684

  Fly   631 VTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEY----------------------- 672
            :.....:.|::|:|||:||::.|.:.::.|:.|.|..::.|:
  Fly   685 LLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQI 749

  Fly   673 --MNRFVNP------------------------------------------------ITNGQYTD 687
              ::..:.|                                                :|:|..|.
  Fly   750 SRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTT 814

  Fly   688 ST-------------------------ERDL------------------------RLMKHRSHIL 703
            |:                         .||.                        |::..|.|:|
  Fly   815 SSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLL 879

  Fly   704 HK----------------------------------------LLEGCIQ---------------- 712
            :.                                        .|.|.|.
  Fly   880 YNRFNIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLA 944

  Fly   713 -RR---------DYSVLAP---------YLPPKH--EYVVYTTLSELQQKLY--GYYMTTHREQS 754
             ||         .|.:|.|         |:||..  :..::|.::..:..:|  |.|.|.:.:::
  Fly   945 YRRFWWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQET 1009

  Fly   755 ------GGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDME---------- 803
                  ...::.|...|.::.:|:.:     ..|.:.|..|..|   ||..||::
  Fly  1010 IEHRVIRSKILKKKTSLIEEMEDVSK-----QKLEIESVEVQTK---SNAKSDVKVTTLLLLPEF 1066

  Fly   804 --------GFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSD 860
                    .::|:.........:.....:...........:|:..:::..:..| :.|.....|.
  Fly  1067 PHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCEN-SQGRELVSSG 1130

  Fly   861 LEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQ 925
            |.:....||.||:           .|.::| ..:..:.||.:|..||.:.:|.|.::|::||..:
  Fly  1131 LALCKPHGGWSSI-----------VVPDKE-TLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTK 1183

  Fly   926 SLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRA 990
            .:|::|.::                      |.....|.|||||..:..|..|...|.  |....
  Fly  1184 MIDLLEEYM----------------------WHRKHRYMRLDGSSKISARRDMVADFQ--TRADI 1224

  Fly   991 RLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKV 1055
            .:||:|||||||||||.||:.|:.:|..|||:.|.|::.|.:|.||.|...:||||..||:|:::
  Fly  1225 FVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERI 1289

  Fly  1056 YERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLI 1120
            .:|                 :|..::...|.:.....||.|     :.||:  ...:|.:.|::.
  Fly  1290 LQR-----------------AREKSEIQRMVISGGNFKPDT-----LKPKE--VVSLLLDDEEIE 1330

  Fly  1121 FKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGS 1185
            .||.:...|.........|:.|||                .::...|.|..|..:      |:.|
  Fly  1331 MKYRQEAKLQSSSPIPAATQSERK----------------RRHPQKDVNMGGTTI------AATS 1373

  Fly  1186 VTSN------------KIFGFRSD-------ILLQLLNMKISKDHQELNQNQVIQLVP--TYLQQ 1229
            .|.|            |.....::       |.....::....:|..|:|.   ..||  |.:||
  Fly  1374 ATQNPDDDVPSCSSAAKRIKLETEEDFIDVGITSSASSVGTDSNHPTLSQE---TYVPGATCVQQ 1435

  Fly  1230 LYNEMNN------GD-PTM--YKDLLNLHSNI--VHPSGMYMNPLLYANQNPNAAGYNQGTGGVP 1283
            ...:..|      || |||  ..:.:|...::  :.|.....:|.......|..:....|..|..
  Fly  1436 TEIDSENEALVVDGDSPTMLGQNESMNFLDDLSGISPMRRRHHPRGTRRGRPRGSTRRGGGHGSI 1500

  Fly  1284 PMAGGSVAHGPPAAPA 1299
            |..........||.||
  Fly  1501 PRVLTPTQAATPAVPA 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	16/103 (16%)
		SNF2_N	458..779	CDD:278600	85/538 (16%)
		DEXDc	483..646	CDD:238005	42/173 (24%)
		Helicase_C	913..1035	CDD:278689	41/121 (34%)
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	23/152 (15%)
		SNF2_N	538..840	CDD:278600	60/338 (18%)
		DEXDc	555..700	CDD:238005	42/173 (24%)
		Helicase_C	1156..1269	CDD:278689	47/136 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467196
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930