DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and brm

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1300	Identity:	289/1300 - (22%)
Similarity:	477/1300 - (36%)	Gaps:	414/1300 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ESSPPRSNTKQSR-----THKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLE-- 100
            :..||:...:||:     .|::...:|...:|......|.:..||               |::
  Fly   306 QQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSS---------------PMQPQ 355

  Fly   101 ---KLLASPKTKERPS-RGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVD 161
               .|...|...:.|. .|..|:.|         |..|..:..|.|.:  ..|..:.|.....:.
  Fly   356 VRGTLPGMPPGSQVPQPGGGPQRQV---------PPAGMPMPKPNRIT--TVAKPVGLDPITLLQ 409

  Fly   162 EEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSE 226
            |.|..:...|.|..:..|..|...|.       :.|.:|..|     .||:|.:|..|:..:...
  Fly   410 ERENRIAARISLRMQELQRLPATMSE-------DLRLQAAIE-----LRALRVLNFQRQLRMEFV 462

  Fly   227 RSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQ--------- 282
            :.:|..:: .|:....| ...|.||..|.:.:..:|.:|     ::.....:|.||
  Fly   463 QCTRRDTT-LETALNIK-LYKRTKRQGLREARATEKLEK-----QQKLEAERKRRQKHLEFLAAV 520

  Fly   283 -----------RRSKSE----SEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSE----VMPQ 328
                       |.:|::    ::|..::.|.|..|:::|:.:...:......:.|.|    ::.|
  Fly   521 LQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQ 585

  Fly   329 RKRRRKK---SESDKGSSDF--------EPEEKQKKKGRKRI---KK--TSSGE----------- 366
            :|.:|..   |::|:..|:.        :.:.|:|::..||:   ||  ..|||
  Fly   586 KKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVA 650

  Fly   367 --------------------------------------------SDGDGDDDKQKNKRKHIRKII 387
                                                        |.|..||.|.|.:.:.    .
  Fly   651 DMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQP----T 711

  Fly   388 KTKDL--------------DLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDE 438
            .|:|.              ||.||  ||.|||..:  .:.|..|      |.:..|:|.|::
  Fly   712 ATEDATDKAQATGNDEDAKDLITK--AKVEDDEYR--TEEQTYY------SIAHTIHEKVVE--- 763

  Fly   439 ESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLS 503
               :|.:.|: |.||:   :|:.|::::.......|..         |||..||||||:|.::|.
  Fly   764 ---QASIMVN-GTLKE---YQIKGLEWLVSLYNNNLNG---------ILADEMGLGKTIQTISLV 812

  Fly   504 HTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKP---------T 559
            ..|:  .|:..:...|||.||||:.||..||..|        .....:..||..|         .
  Fly   813 TYLM--DRKKVMGPYLIIVPLSTLPNWVLEFEKW--------APAVGVVSYKGSPQGRRLLQNQM 867

  Fly   560 RIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEK 624
            |..|.|       |.:..|: |.|    |.|.:..|.:.:.|           :.||||.:||..
  Fly   868 RATKFN-------VLLTTYE-YVI----KDKAVLAKIQWKYM-----------IIDEGHRMKNHH 909

  Fly   625 TSISKAV-TRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLL---GTYKEYMNRFVNPI-TNGQ 684
            ..:::.: |......|::||||||||.|.|.:.::.|:.|::.   .|::::.|.   |. |.|:
  Fly   910 CKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNA---PFATTGE 971

  Fly   685 YTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTT 749
            ..:..|.:..|:..|   |||:|...:.||....:...||.|.||::...:|.||:.||     .
  Fly   972 KVELNEEETILIIRR---LHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLY-----K 1028

  Fly   750 HREQSG-----GDVVGK----GAR-LFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEG 804
            |.:..|     |...||    ||: |......||::..||...:                 .:|.
  Fly  1029 HMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQ-----------------HIEE 1076

  Fly   805 FICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGG 869
            ..||.|                                                          |
  Fly  1077 KYCDHT----------------------------------------------------------G 1083

  Fly   870 GSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFL 934
            |..|            |...:|..|  |.|..:|.|:|.:.:|...::|:|.|..|.:.:||.:|
  Fly  1084 GHGV------------VSGPDLYRV--SGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYL 1134

  Fly   935 SLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRAR-----LFL 994
            .                     |.. ..|.||||:...|.|..:.::||      |:     :||
  Fly  1135 G---------------------WRQ-FGYLRLDGTTKAEDRGELLRKFN------AKGSDVFVFL 1171

  Fly   995 ISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKV---- 1055
            :||||||||:||..|:.|||||..|||..|.|:..|.:|.||.....:.||:.:.::|:::
  Fly  1172 LSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAA 1236

  Fly  1056 -YERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEIL--TEHE 1117
             |:..:.::.....:.|::.......|.....|:..:.:...|.|   :|.|.:...::  :|.|
  Fly  1237 RYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENE---VPDDEMINMMIARSEEE 1298

  Fly  1118 KLIFKYHEHDSLLEQEE----HENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQ 1178
            ..|||..:.:...|.||    .|.|.:|.....|...:.::   |:...| .||.:.    ::|:
  Fly  1299 IEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDE---VERFHY-QYDEDT----ILGR 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	17/104 (16%)
		SNF2_N	458..779	CDD:278600	96/344 (28%)
		DEXDc	483..646	CDD:238005	50/172 (29%)
		Helicase_C	913..1035	CDD:278689	43/126 (34%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903	19/107 (18%)
		HSA	501..573	CDD:214727	10/71 (14%)
		BRK	649..693	CDD:197800	0/43 (0%)
		PHA02934	687..>824	CDD:165245	44/171 (26%)
		SNF2_N	776..1071	CDD:278600	98/347 (28%)
		DEXDc	793..932	CDD:238005	50/180 (28%)
		Helicase_C	1097..1212	CDD:278689	49/142 (35%)
		SnAC	1304..1375	CDD:291293	12/59 (20%)
		Bromo_SNF2L2	1425..1530	CDD:99947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467186
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930