DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment XNP and CG7376

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001261471.1	Gene:	CG7376 / 38715	FlyBaseID:	FBgn0035689	Length:	1270	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	138/748 - (18%)
Similarity:	254/748 - (33%)	Gaps:	213/748 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 DLTTKEAAKEEDDRRKRIEDRQKLYNRI----FVKS---ESVEINELVLDFDEESKKALLQVDKG 450
            ||..:..:..|::.:..:......||.:    |:|:   ::::...|:|....|..:..:.||..
  Fly   615 DLLARLKSNNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNISVDSV 679

  Fly   451 L--------------------LKKL--KPHQVAGVKFMW----------DACFETLKESQEKPGS 483
            |                    |.:|  |.:|....:..|          ::...:..|:.||...
  Fly   680 LQIHAIYNLLQASSLAPAEHKLTELEHKKYQAQMSRLEWKYLEDNTRVLESALSSYNENLEKVSE 744

  Fly   484 GCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFAN---RND 545
                     |.|..:..||.....:...:|.:...:                 |.|..:   |.:
  Fly   745 ---------LEKRFEGSTLDLLATMVNHKTSLHDAI-----------------WNKVRDDFFRQN 783

  Fly   546 IEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKA---------KGLRKKQREQ-- 599
            |.|..:.........::.::.|.|:             |.|.|:         ||:.::..|.
  Fly   784 ISVERLENVNSMAGMLYFMDIWHNK-------------LQNLKSTLIAEFEFLKGVMQQACEAIK 835

  Fly   600 ----LMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKR-RIVLTGTPLQNNLREYYCMIQ 659
                |...:::...::.||   ||......:..|.|...:.:. |:.|    ::::|.::.|::.
  Fly   836 TGVLLSMEIINFIENVTVC---HLTDILDANKDKPVKPKKHRYCRLCL----IRDSLNQFECLLF 893

  Fly   660 FVKPNLLGTYKEYMNRFVNPITNGQYTDS------TERDLRLMKHRSHILHKLLEGCIQ-----R 713
            ..|.:...|..|.:.   ||.....:..|      :::|....|.......:|| .|:|     :
  Fly   894 AKKLDEKATVTEGLE---NPSMEISFIKSIFAFLRSKQDFSEWKEECQSKLELL-SCLQDLVKFQ 954

  Fly   714 RDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTH-REQSGGDVVGKGARLFQDFQDLRRIWT 777
            ..|.:       :.||:| ....||:.......:|.. .|||...::  ..:|.:..|      .
  Fly   955 IKYWI-------EVEYMV-KAFDELEMCKMRILLTDDPEEQSNYRIL--ACQLDEQLQ------F 1003

  Fly   778 HPMNLRVNSDNV--IAKRL-----LSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGL 835
            :..||:.:..|.  :..||     |..|.:|....||...|:......   .|..|.....:..:
  Fly  1004 NQYNLQTSQLNFTRLCGRLKYLKHLKEDSADKPCPICQTQDDVRYVMM---VCGHFVCQHCLDSM 1065

  Fly   836 AASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQK------DDPSEWW--KPFVEERELN 892
                      :.:||.||                   |.|      |.|..::  :|...:..:.
  Fly  1066 ----------RRKNGRAG-------------------VTKCPLCRQDSPQLYYSVRPGAHKSIIG 1101

  Fly   893 NVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCW 957
            :.......::.|.|..:.|...:|::||||....|..|...|||.....:|.....|..|||
  Fly  1102 DFSTKISSVVELVLKIKGENEQEKIIVFSQWQAILIEIARALSLNGIQFRNKCTNKDFDDFK--- 1163

  Fly   958 TSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPS 1022
                                     |.::|:...|..:|  .|..|:||:.|..|.:.:...||.
  Fly  1164 -------------------------NPLSNVTCLLMPLS--KGSKGLNLIEATHVFLVEPILNPG 1201

  Fly  1023 HDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKV 1055
            .:.|:|.|::||||.:|..::|.|...|:|:.:
  Fly  1202 DERQAIGRIHRFGQKRPTKVHRFIVNETIEENI 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332
		SNF2_N	458..779	CDD:278600	58/361 (16%)
		DEXDc	483..646	CDD:238005	27/181 (15%)
		Helicase_C	913..1035	CDD:278689	31/121 (26%)
CG7376	NP_001261471.1	SNF2_N	221..601	CDD:278600
		PHD_SF	281..320	CDD:304600
		TPR	636..669	CDD:197478	6/32 (19%)
		RING	1037..1083	CDD:238093	11/77 (14%)
		HepA	<1096..1238	CDD:223627	42/169 (25%)
		Helicase_C	1108..1214	CDD:278689	34/135 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840