DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and Iswi

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	220/928 - (23%)
Similarity:	367/928 - (39%)	Gaps:	281/928 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 SKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRR----RKKSESDKGSSDF 345
            ||:::.|....|..:.|...:....|||::|.   ..|:::...|.||    .|::|........
  Fly     2 SKTDTAAVEATEENSNETTSDAATSSSGEKEA---EFDNKIEADRSRRFDFLLKQTEIFTHFMTN 63

  Fly   346 EPEEKQKKKGR-KRIKKTSSGESDGDGDDDKQKNKRKH-IRKIIKTKDLDLTTKEAAKEEDDRRK 408
            ..:...|.||| |:||           |.||:|:...| .||..:.:|.:|..:::|.:|
  Fly    64 SAKSPTKPKGRPKKIK-----------DKDKEKDVADHRHRKTEQEEDEELLAEDSATKE----- 112

  Fly   409 RIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFET 473
                                    :..||...    ..:..|   :::.:|:.|:.:|     .:
  Fly   113 ------------------------IFRFDASP----AYIKSG---EMRDYQIRGLNWM-----IS 141

  Fly   474 LKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWM 538
            |.|:    |...|||..||||||||.::|...|.....:.|..  ::|.|.||:.||..||..|.
  Fly   142 LYEN----GINGILADEMGLGKTLQTISLLGYLKHFKNQAGPH--IVIVPKSTLQNWVNEFKKWC 200

  Fly   539 KFANRNDIEVYDISRYKDKPTR------IFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQR 597
            .       .:..:....|:.||      :....||    .||:..|:|.     .:.|.:.||..
  Fly   201 P-------SLRAVCLIGDQDTRNTFIRDVLMPGEW----DVCVTSYEMC-----IREKSVFKKFN 249

  Fly   598 EQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVK 662
            .:.:           |.||.|.:||||:.:|:.:...:|..|:::|||||||||.|.:.::.|:.
  Fly   250 WRYL-----------VIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLL 303

  Fly   663 PNLLGT---YKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLP 724
            |::..:   :.|:.|           |::...|..|:..    ||.:|:..:.||..:.:...|.
  Fly   304 PDVFNSSEDFDEWFN-----------TNTCLGDDALITR----LHAVLKPFLLRRLKAEVEKRLK 353

  Fly   725 PKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNV 789
            ||.|..::..||::|:..|
  Fly   354 PKKEMKIFVGLSKMQRDWY---------------------------------------------- 372

  Fly   790 IAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGG 854
             .|.||.:.|                                   :...:|||:|.:.:|
  Fly   373 -TKVLLKDID-----------------------------------VVNGAGKVEKMRLQN----- 396

  Fly   855 GDSDSDLEMLGGLGGGSSVQK-------DDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEA 912
                    :|      ..::|       .|.:|...|:..:..|  |::|.|:.||.:||.:.:.
  Fly   397 --------IL------MQLRKCTNHPYLFDGAEPGPPYTTDTHL--VYNSGKMAILDKLLPKLQE 445

  Fly   913 IGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREA 977
            .|.::|:|||..:.||::|.:     .:.:||                 :|.||||....|.|..
  Fly   446 QGSRVLIFSQMTRMLDILEDY-----CHWRNY-----------------NYCRLDGQTPHEDRNR 488

  Fly   978 MCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYI 1042
            ..::| |:.|....||::|||||||||||..|:.|:|:|..|||..|.|::.|.:|.||.|...:
  Fly   489 QIQEF-NMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRV 552

  Fly  1043 YRLIAMGTMEQKVYERQVAKQATAKRVIDEQQI----SRHYNQTDLM--------ELYSYELKPS 1095
            :|||...|:|:|:.||...|....|.||...::    |...|:.:::        :::|.:....
  Fly   553 FRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDI 617

  Fly  1096 TEREMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHE---NLTEEERKSAWAEYEAEKTRT 1157
            |:.::.::.:.   .|..|..:|...     |||.|.....   :...|...|:..::|.|..|.
  Fly   618 TDEDIDVILER---GEAKTAEQKAAL-----DSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWRE 674

  Fly  1158 VQASQYMSYDRNAFGNQV 1175
            .|       ..||.||.:
  Fly   675 KQ-------KLNALGNWI 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	13/53 (25%)
		SNF2_N	458..779	CDD:278600	82/329 (25%)
		DEXDc	483..646	CDD:238005	48/168 (29%)
		Helicase_C	913..1035	CDD:278689	44/121 (36%)
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	7/39 (18%)
		SNF2_N	131..411	CDD:278600	93/433 (21%)
		DEXDc	148..287	CDD:238005	48/167 (29%)
		HELICc	422..553	CDD:238034	55/155 (35%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467163
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840