Protein Alignment XNP and Smarca2

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001004446.2
• Gene: Smarca2 / 361745
• RGDID: 1302988
• Length: 1597
• Species: Rattus norvegicus
• Alignment Length: 1304
• Identity: 289/1304 - (22%)
• Similarity: 473/1304 - (36%)
• Gaps: 395/1304 - (30%)

  Fly    29 RRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSS--SDSDQAVANSSANDEEKEPV 91
            :::...:.:...:....|.:....|.:..:..:....|.||.:  |...|.:..::.|.::|
  Rat   223 QQQQQQQQQQQPQQPQQPQQQTQAQPQQQQQQQQQPPALVSYNRPSGPGQELLMTAQNTQQK--- 284

  Fly    92 CKIRIVPLEKLLASPKTKERPS----RGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASII 152
                       |::|....|||    ..:|.....:...|.::|..|..  .|..:.:.|.:.|.
  Rat   285 -----------LSAPAPSGRPSPAPPAATQPTATAVPGPSVQQPAPGQP--SPVLQLQQKQSRIS 336

  Fly   153 ELSDSEEVD--------------------EEEESLLVAIP----------------------LPK 175
            .:...:.:|                    :|.|||..::|                      |.:
  Rat   337 PIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRLLNFQRQLRQ 401

  Fly   176 E-------------AQQTKPEKNSSKAS------KESIEKRQKAQKE------------ATTSSA 209
            |             |..:|..|.|.:.:      .|.:||:||.::|            :....|
  Rat   402 EVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHA 466

  Fly   210 RAIRSVNGTRRGSL------------SSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQK 262
            :..:..:.:..|.:            ::||..:..:.|.|..        |::|:.....:..:|
  Rat   467 KDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKE--------RMRRLMAEDEEGYRK 523

  Fly   263 PKKMSSD-------------------------SEEAATTSKKSRQRRSKSESEADSDYEA--PAA 300
            ......|                         ..:||...||.|:||.|:|..|:....|  |..
  Rat   524 LIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRRKKAEENAEGGEPALGPDG 588

  Fly   301 EEEEEEERKSS---------------GDEEEAANSSDS--------EVMPQRKRRRKKSESDKGS 342
            |..:|..:.|.               |.|...|:..|:        ||.|       :|:|::..
  Rat   589 EPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAP-------RSDSEESE 646

  Fly   343 SDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRR 407
            ||:|.|:::::..|:..::...      .|.:.::...|..::||:      |.|:...:|...:
  Rat   647 SDYEEEDEEEESSRQETEEKIL------LDPNSEEVSEKDAKQIIE------TAKQDVDDEYSMQ 699

  Fly   408 KRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFE 472
            ......|..|......||.|           |.:.|||     :...||.:|:.|:::|......
  Rat   700 YSARGSQSYYTVAHAISERV-----------EKQSALL-----INGTLKHYQLQGLEWMVSLYNN 748

  Fly   473 TLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSW 537
            .|..         |||..||||||:|.:.|...|:.:.|..|  ..|||.||||::||..||..|
  Rat   749 NLNG---------ILADEMGLGKTIQTIALITYLMEHKRLNG--PYLIIVPLSTLSNWTYEFDKW 802

  Fly   538 MKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEG--GVCILGYDMYRILANEKAKGLRKKQREQL 600
            ..       .|..|| ||..|.....|......|  .|.:..|: |.|    |.|.:..|.|.:.
  Rat   803 AP-------SVVKIS-YKGTPAMRRSLVPQLRSGKFNVLLTTYE-YII----KDKHILAKIRWKY 854

  Fly   601 MQALVDPGPDLVVCDEGHLLKNEKTSISKAV-TRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPN 664
            |           :.||||.:||....:::.: |.....|||:||||||||.|.|.:.::.|:.|.
  Rat   855 M-----------IVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPT 908

  Fly   665 LL---GTYKEYMNRFVNPIT-NGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPP 725
            :.   .|::::.|.   |.. .|:..|..|.:..|:..|   |||:|...:.||....:...||.
  Rat   909 IFKSCSTFEQWFNA---PFAMTGERVDLNEEETILIIRR---LHKVLRPFLLRRLKKEVESQLPE 967

  Fly   726 KHEYVVYTTLSELQQKLY------GYYMTTHREQSGGDVVGKGA--RLFQDFQDLRRIWTHPMNL 782
            |.|||:...:|.||:.||      |..:|...|:   |..|||.  .|......||:|..||
  Rat   968 KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEK---DKKGKGGAKTLMNTIMQLRKICNHP--- 1026

  Fly   783 RVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKT 847
                                  ::....:|..|                 ..|..|:|.:
  Rat  1027 ----------------------YMFQHIEESFA-----------------EHLGYSNGVI----- 1047

  Fly   848 RNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEA 912
             ||                            :|.::.            |.|..:|.|:|.:..|
  Rat  1048 -NG----------------------------AELYRA------------SGKFELLDRILPKLRA 1071

  Fly   913 IGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREA 977
            ...::|:|.|....:.::|.:.:.     :|:.                 |.||||:...|.|.|
  Rat  1072 TNHRVLLFCQMTSLMTIMEDYFAF-----RNFL-----------------YLRLDGTTKSEDRAA 1114

  Fly   978 MCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYI 1042
            :.|:||. ...:..:||:||||||||:||.||:.|||||..|||..|.|:..|.:|.||.....:
  Rat  1115 LLKKFNE-PGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRV 1178

  Fly  1043 YRLIAMGTMEQKVYERQVAKQATAKRVID----EQQISRHYNQTDLMELYSYELKPSTEREMPIL 1103
            .||..:.::|:|:......|....::||.    :|:.|.|..:..|..:..:|.:...|.|   :
  Rat  1179 LRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDE---V 1240

  Fly  1104 PKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHEN------LTEEERKSAW------------AEY 1150
            |.|....:::...|:....:...|....:|:..|      |.||:...:|            .|.
  Rat  1241 PDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEE 1305

  Fly  1151 EAEK 1154
            |.||
  Rat  1306 EEEK 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	69/379 (18%)
		HepA	<382..1071	CDD:440319	187/703 (27%)
		DEXHc_ATRX	455..699	CDD:350826	78/250 (31%)
Smarca2	NP_001004446.2	PHA03378	<74..389	CDD:223065	27/181 (15%)
		QLQ	173..207	CDD:462622
		HSA	443..515	CDD:214727	11/79 (14%)
		BRK	596..639	CDD:462196	8/49 (16%)
		DEXHc_SMARCA2	708..958	CDD:350821	93/306 (30%)
		PLN03142	727..>1209	CDD:215601	174/636 (27%)
		SnAC	1266..1333	CDD:464219	10/44 (23%)
		Bromodomain	1340..>1426	CDD:445827
		Bromo_SNF2L2	1389..1513	CDD:99947