Protein Alignment XNP and Ercc6l2

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_038952187.1
• Gene: Ercc6l2 / 361197
• RGDID: 1561537
• Length: 1561
• Species: Rattus norvegicus
• Alignment Length: 843
• Identity: 200/843 - (23%)
• Similarity: 346/843 - (41%)
• Gaps: 238/843 - (28%)

  Fly   294 DYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFE----PEEKQKKK 354
            |..||....:..::|...| |...|.|.|::.:.:..  .|....|:....|.    |:.::||.
  Rat     2 DASAPHPRADSHKDRWCPG-ERCLAPSLDNKKLCEAS--IKSITVDENGEPFAVVLYPDFQEKKI 63

  Fly   355 GRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNR 419
            ..:|:::.              |:.:.|.|.:|             .:::|..|.....||:.:.
  Rat    64 PLQRLQEV--------------KSTKDHSRSLI-------------FDDEDLEKPYFPDQKIPSL 101

  Fly   420 IFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSG 484
            :    .:.:::|     |.:|      :...:.:.|:.:|..|.:|::....:         |.|
  Rat   102 V----SAFQLSE-----DGDS------IPYTINRYLRDYQREGAQFLYRHYIK---------GRG 142

  Fly   485 CILAHCMGLGKTLQVVT------------------LSHTLLVNTRR----TGVDRVLIISPLSTV 527
            |||...||||||:||::                  :...||.:.::    |.....||::|||.:
  Rat   143 CILGDDMGLGKTIQVISFLAAVLHKKGTREDIENNMPEFLLKSMKKESSSTARKMFLIVAPLSVL 207

  Fly   528 NNWAREFTSWMKF------ANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILAN 586
            .||..|..:|..|      .::.|.|   ::|.|.:...|            .:..|:..| |..
  Rat   208 YNWKDELDTWGYFRVTVLHGSKKDNE---LTRLKQRKCEI------------ALTTYETLR-LCL 256

  Fly   587 EKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNL 651
            |:...|..               ..::.||.|.::|....:::.:..::.|.||.||||.||||:
  Rat   257 EELNSLEW---------------SAIIVDEAHRIRNPNARVTEVMKAVKCKVRIGLTGTILQNNM 306

  Fly   652 REYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDY 716
            :|.:|::.:..|.|||:...:..:|.:|:.:||...:|:|:|...:...|.|.|.:.|...||..
  Rat   307 KELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGYFLRRTK 371

  Fly   717 SVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTT-------------------------HREQSGG 756
            :::...||.|.:.:||::|::.|:.:|...:.|                         ::..|.|
  Rat   372 TLIKGQLPKKEDRMVYSSLTDFQKAVYQTVLETEDVALILTSSQPCTCGSGQKRRKCCYKTNSQG 436

  Fly   757 DVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSD 821
            |.|  ..........|:::..|...|:..|.:...:.|:..        ||     |:..|...|
  Rat   437 DTV--RTLCLSYLTVLQKVANHVALLQAASTSKHQETLIKR--------IC-----DQVFSRFPD 486

  Fly   822 SCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFV 886
            .                   |:|.|           |:..|.|           .||.
  Rat   487 F-------------------VQKSK-----------DAAFETL-----------SDPK------- 503

  Fly   887 EERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVG 951
                     :|.|:.:|.:||.......||:|:||.|.:.|||::.:
  Rat   504 ---------YSGKMKVLDQLLNHFRKHRDKVLLFSFSTKLLDVLQQY------------------ 541

  Fly   952 DFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFD 1016
                |..||.||.|||||...|:|..:.|:||:..::  .:.|:||.|||||:|.:.||.|::||
  Rat   542 ----CMASGLDYRRLDGSTKSEERLKIVKEFNSSQDV--NICLVSTMAGGLGLNFIGANVVILFD 600

  Fly  1017 VSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHY 1079
            .:|||::|.|:|.|.||.||.:...::|||::||:|:.:|.|||.||.....|:..:...|::
  Rat   601 PTWNPANDLQAIDRAYRIGQCRDVKVFRLISLGTVEEIMYLRQVYKQQLHCVVVGSENAKRYF 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	28/169 (17%)
		HepA	<382..1071	CDD:440319	182/741 (25%)
		DEXHc_ATRX	455..699	CDD:350826	68/271 (25%)
Ercc6l2	XP_038952187.1	Tudor_SF	17..72	CDD:470623	12/71 (17%)
		HepA	<47..649	CDD:440319	187/779 (24%)
		DEXHc_ERCC6L2	122..369	CDD:350763	72/286 (25%)
		VIGSSK	<1132..1155	CDD:464308