DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and Chd1

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster

Alignment Length:	1381	Identity:	310/1381 - (22%)
Similarity:	488/1381 - (35%)	Gaps:	469/1381 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCK-I 94
            |||....|..:.::....:.|..|.:     .||..:..|.||||.:..|||......||..| :
  Fly    24 ESANSIGSDEQDDTREEANGTDHSGS-----GSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSL 83

  Fly    95 RIVPLEKLLASPK--------TKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASI 151
            .:.......|:.:        |.::....|...:.:.:||..|.|            |..:|.||
  Fly    84 SVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGP------------SDQRNQSI 136

  Fly   152 IELSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVN 216
            ...:.|..             ||      |||:|..:.::....::|.|...:...|:.:..:|:
  Fly   137 NNANTSSS-------------LP------KPEQNEEEDNETEAGQQQPASDASADESSDSSANVS 182

  Fly   217 GTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEA-ATTSKKS 280
            .|         ||.:||...|...||||            |:.|:||...:..|::| |..:||.
  Fly   183 PT---------SSSSSSEEEEEDYRPKR------------TRQARKPPTAAEKSKKAPAPKNKKK 226

  Fly   281 RQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSD- 344
            .....:|:...|||.|...|::           .:.||.:|.|::..|::|||.|..|.:.|.|
  Fly   227 TWDSDESDESEDSDDEVSTAQK-----------RKPAATTSRSKLAQQQQRRRVKPFSSEDSDDD 280

  Fly   345 ---------------------------------FE------------PEEKQKKKGRKRIKKTSS 364
                                             ||            .||::|.:..:||....:
  Fly   281 DASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRA 345

  Fly   365 G--------------ESDG----DGDDDKQ-KNKRKHIRKIIKTKD---LDLTTKEAAKEEDDRR 407
            |              |.:|    .|.|:|| .:.....:.:||.|.   :..|.:..|...|.:.
  Fly   346 GKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKA 410

  Fly   408 KRI--------EDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKP------- 457
            |.:        :::::.|.|.:...|.::..|..|:...|..|:...||:.:.|..||
  Fly   411 KGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEEY 475

  Fly   458 --------------HQVAGVKFMWDAC--------------------------FETLKESQEKPG 482
                          ...|.|...|..|                          |..:|...|...
  Fly   476 LCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLS 540

  Fly   483 SG------------------C-----ILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPL 524
            ||                  |     |||..||||||:|.:...::|.......|  ..|.:.||
  Fly   541 SGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYG--PFLCVVPL 603

  Fly   525 STVNNWAREFTSWMKFANRNDIEVY--DISRYKDKPTRIFKLNEW---------FNEGGVCILGY 578
            ||:..|.|||..|....|   :..|  ||     |...:.:..||         ||    |||
  Fly   604 STMTAWQREFDLWAPDMN---VVTYLGDI-----KSRELIQQYEWQFESSKRLKFN----CIL-- 654

  Fly   579 DMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLT 643
            ..|.|:       |:.||....:|...      ::.||.|.|||:.:.:.|::....|..|:::|
  Fly   655 TTYEIV-------LKDKQFLGTLQWAA------LLVDEAHRLKNDDSLLYKSLKEFDTNHRLLIT 706

  Fly   644 GTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLE 708
            ||||||:|:|.:.::.|:.|:...|::.:..:..|....| ||.               ||:.||
  Fly   707 GTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKG-YTR---------------LHQQLE 755

  Fly   709 GCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGAR-----LFQD 768
            ..|.||....:...||.|.|.::...::.||::.|.:.:|     ...|.:.||.|     ....
  Fly   756 PYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILT-----KNFDALRKGKRGSTSTFLNI 815

  Fly   769 FQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMS 833
            ..:|::...|...:|
  Fly   816 VIELKKCCNHAALIR-------------------------------------------------- 830

  Fly   834 GLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSP 898
                                    .|:.|::|       :|:|:..:           ..:..|.
  Fly   831 ------------------------PSEFELMG-------LQQDEALQ-----------TLLKGSG 853

  Fly   899 KLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDY 963
            ||::|.:||.:.:..|.::|:|||.::.|||:..:|     ..:::.|:
  Fly   854 KLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYL-----QKRHFPFQ---------------- 897

  Fly   964 FRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSI 1028
             |||||...|.|......| |....:...||:|||||||||||..|:.|:|||..|||.:|.|:.
  Fly   898 -RLDGSIKGEMRRQALDHF-NAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQ 960

  Fly  1029 FRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQ-------------ATAKRVIDE-----QQI 1075
            .|.:|.||.....||||:...::|:::.||  |||             .|.:.|:|:     ...
  Fly   961 ARAHRIGQKNQVNIYRLVTARSVEEQIVER--AKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSN 1023

  Fly  1076 SRHYNQTDLM--------ELYSYE---------------LKPSTEREMPILPKDRLF-----AEI 1112
            |..:|:.||.        ||:..|               .:..|..|.|.:|.|.|.     |.|
  Fly  1024 SNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRNEDPEMPADDLLSAFKVASI 1088

  Fly  1113 LTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQ---------YMSYDR 1168
            ..      |:....||:.:|:::....|::.|. |.:...|..|.....|         |:...|
  Fly  1089 AA------FEEEPSDSVSKQDQNAAGEEDDSKD-WDDIIPEGFRKAIDDQERAKEMEDLYLPPRR 1146

  Fly  1169 NAFGNQVMGQFGNASG 1184
            ....||..|:.|...|
  Fly  1147 KTAANQNEGKRGAGKG 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	22/77 (29%)
		SNF2_N	458..779	CDD:278600	95/385 (25%)
		DEXDc	483..646	CDD:238005	54/196 (28%)
		Helicase_C	913..1035	CDD:278689	44/121 (36%)
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	9/47 (19%)
		Chromo	458..509	CDD:278797	9/50 (18%)
		SNF2_N	548..829	CDD:278600	87/330 (26%)
		DEXDc	564..709	CDD:238005	51/173 (29%)
		Helicase_C	852..967	CDD:278689	50/137 (36%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467235
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840