DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment XNP and Ercc6

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_001074690.1 Gene:Ercc6 / 319955 MGIID:1100494 Length:1481 Species:Mus musculus


Alignment Length:1224 Identity:285/1224 - (23%)
Similarity:505/1224 - (41%) Gaps:368/1224 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PNARHTDAATPLTTDDSN----------SSSVSRRESATESKSASESESSPPRS-------NTKQ 53
            ||:.|......|.:..:|          :..||   .|.|..|::..|..|..|       .|::
Mouse     7 PNSTHPQEQDCLPSQHANAYKDMPVGQENGGVS---EAGECLSSTSCEYGPSTSAEACVLAATRR 68

  Fly    54 SRTHKNVKASGKATVSSSSDS-----------DQAVAN-----------------SSANDEEKE- 89
            ..|..::.......|..|:.:           ||||..                 :...|.||| 
Mouse    69 GPTLLHIDRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASCVAQLADAEKEY 133

  Fly    90 -------PVCKIRIVPLEKLL--ASPKT--------------KERPSRGSQQKNVTIN------- 124
                   ..|...:..:.|::  .||:.              :::.::..|.|.:|..       
Mouse   134 QSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAI 198

  Fly   125 ---------------DSSDEEP---LKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAI 171
                           :..|.||   ..|| :::||:::.           .||:....:......
Mouse   199 LGGAGVQVELDHASLEEDDAEPGPSCLGS-MLMPAQETA-----------WEELIRTGQMTPFGT 251

  Fly   172 PLPKEAQQTKP-----------EKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSS 225
            |.|:: |:.||           ||..::.::.|.|::::|   ||..:|:....::.:.|.::.:
Mouse   252 PAPQK-QEKKPRKIMLNEASGFEKYLAEQAQLSFERKKQA---ATKRTAKKAIVISESSRAAIET 312

  Fly   226 ERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESE 290
            :...| |...:::..|.|:...:|:|            :.:....:....:.||..:...:.|:|
Mouse   313 KADQR-SQVLSQTDKRLKKHSRKLQR------------RALQFQGKVGLPSGKKPLEPEVRPEAE 364

  Fly   291 ADSDYE----APAAEEEEEEERKSSGDEEE--AANSSDS---EVMPQRKRRR--KKSESDKGSSD 344
            .|::.|    :|...|||||:     :|||  |:.|||.   |:.|.|||::  ||....:...|
Mouse   365 GDTEGEESGSSPTDGEEEEEQ-----EEEEGVASLSSDDVSYELKPLRKRQKYQKKVPVQEIDDD 424

  Fly   345 FEP---EEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDR 406
            |.|   ||.:..:||...:|.:..:.|||.|..||:.:|.:                        
Mouse   425 FFPSSEEEDEAMEGRGGGRKVARRQDDGDEDYYKQRLRRWN------------------------ 465

  Fly   407 RKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDA-C 470
            |.|::|::|   |:.::.:|.|.:   .:|||..|     |...|.|||..:|..||:::|:. |
Mouse   466 RLRLQDKEK---RLKLEDDSEESD---AEFDEGFK-----VPGFLFKKLFKYQQTGVRWLWELHC 519

  Fly   471 FETLKESQEKPGSGCILAHCMGLGKTLQVVT----LSHTLL----VNTRRTGVDRVLIISPLSTV 527
            .:          :|.||...||||||:|::.    ||::.:    .|.|..|:...:|:.|.:.:
Mouse   520 QQ----------AGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVM 574

  Fly   528 NNWAREFTSW---MKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKA 589
            :.|.:||.:|   .:.|     .:::...|..|..|:.:...:.:  ||.|..|...|::.::.:
Mouse   575 HQWVKEFHTWWPPFRVA-----VLHETGSYTHKKERLIRDIVYCH--GVLITSYSYIRLMQDDIS 632

  Fly   590 KGLRKKQREQLMQALVDPGPD--LVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLR 652
            :                  .|  .|:.||||.::|...:::.|..:.||..||:|:|:|:|||||
Mouse   633 R------------------HDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLR 679

  Fly   653 EYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYS 717
            |.:.:..|:.|..|||...:|.:|..|||.|.|::::...::.....:.:|...:...:.||..|
Mouse   680 ELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKS 744

  Fly   718 --VLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPM 780
              .::..||.|:|.|::..|::.|.|:|                       |:|.|.:.::    
Mouse   745 DVKMSLSLPDKNEQVLFCRLTDEQHKVY-----------------------QNFIDSKAVY---- 782

  Fly   781 NLRVNSDNVIAKRLLSNDDSDMEGF-----ICDETDEDEAASNSSDSCETFKSDASMSGLAASSG 840
                        |:|:.::....|.     ||:..|                         ..||
Mouse   783 ------------RILNGENQIFSGLVALRKICNHPD-------------------------LFSG 810

  Fly   841 KVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLR 905
            ..|       ||.|...|.                          :||.:..:...|.|::::..
Mouse   811 GPK-------NASGPPEDE--------------------------LEEEQFGHWRRSGKMIVVES 842

  Fly   906 LLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSC 970
            ||:.....|.::|:||||.|.|.::|.||       :.:::               .|.::||:.
Mouse   843 LLKIWHRQGQRVLLFSQSRQMLHILEVFL-------RAHKY---------------SYLKMDGTT 885

  Fly   971 SVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFG 1035
            ::..|:.:..::|..|::  .:||::||.||||:||..||||:|:|..||||.|||:..|.:|.|
Mouse   886 TIASRQPLITKYNEDTSI--FVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIG 948

  Fly  1036 QIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYS 1089
            |.|...:|||:..||:|:|:|.||:.||....||:.:.:..|.:...||.||::
Mouse   949 QKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFT 1002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 76/311 (24%)
HepA <382..1071 CDD:440319 178/709 (25%)
DEXHc_ATRX 455..699 CDD:350826 69/257 (27%)
Ercc6NP_001074690.1 N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000250|UniProtKB:Q03468 1..506 118/570 (21%)
cc_ERCC-6_N 83..159 CDD:411064 12/75 (16%)
46 <122..>199 CDD:222878 11/76 (14%)
HepA 280..983 CDD:440319 231/914 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 309..452 40/160 (25%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 642..645 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1040..1096
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1114..1238
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1372
CSA-interacting motif (CIM). /evidence=ECO:0000250|UniProtKB:Q03468 1373..1385
Ubiquitin-binding domain (UBD). /evidence=ECO:0000250|UniProtKB:Q03468 1387..1416
CSB_WHD 1410..1480 CDD:439329
Winged-helix domain (WHD). /evidence=ECO:0000250|UniProtKB:Q03468 1417..1481
Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000250|UniProtKB:Q03468 1434..1481
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.