Protein Alignment XNP and HELLS

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001275996.1
• Gene: HELLS / 3070
• HGNCID: 4861
• Length: 884
• Species: Homo sapiens
• Alignment Length: 1030
• Identity: 249/1030 - (24%)
• Similarity: 386/1030 - (37%)
• Gaps: 346/1030 - (33%)

  Fly   259 PAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEE--------ERKSSGDEE 315
            ||::|.. |..||..|..            .:.|:....||..||||:        |||..   |
Human     2 PAERPAG-SGGSEAPAMV------------EQLDTAVITPAMLEEEEQLEAAGLERERKML---E 50

  Fly   316 EAANSSDSEVMPQRKRR-RKKSESDKGSSDF-----------EPEEKQKKKGRKRIKKTSSGESD 368
            :|..|.|.|....|.|| :...|.....|.|           |.::|:|.:.:|...|...|::.
Human    51 KARMSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLERKKESLKVKKGKNS 115

  Fly   369 GDGDDDKQKNKRK--------HIRKIIKTKDLDLTTKEAAKEEDDRRKR-----IEDRQK----- 415
            .|..::|...::|        :|.:::..:::....|:..||.:|....     :||.||
Human   116 IDASEEKPVMRKKRGREDESYNISEVMSKEEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSN 180

  Fly   416 --LYNRIFVKSESVEINELVLDFDEESK----KALLQVDK----GLLKKLKPHQVAGVKFMWDAC 470
              :.:|:   ||:|..|.... ||...|    ....|..|    |:::..:...:..::.:|:
Human   181 SIIKDRL---SETVRQNTKFF-FDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWE-- 239

  Fly   471 FETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFT 535
                      .|...|||..||||||:|.:.   |:.:..:|......|:..||||:.||..||.
Human   240 ----------NGINGILADEMGLGKTVQCIA---TIALMIQRGVPGPFLVCGPLSTLPNWMAEFK 291

  Fly   536 SWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILAN-EKAKG-------- 591
            .:.                .|.||.::...:           .:..:::.| .|.||
Human   292 RFT----------------PDIPTMLYHGTQ-----------EERQKLVRNIYKRKGTLQIHPVV 329

  Fly   592 -----LRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNL 651
                 :..:.|..|.....    ..::.||||.:||.|..:.:.:.|.....:::||||||||||
Human   330 ITSFEIAMRDRNALQHCYW----KYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNL 390

  Fly   652 REYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKL---------- 706
            .|.:.::.|:.|::....|.:.:.|  .||:   ...|..|:...:...::||.|
Human   391 SELWSLLNFLLPDVFDDLKSFESWF--DITS---LSETAEDIIAKEREQNVLHMLHQERIPRMYV 450

  Fly   707 --------LEGCIQRR-------------------DYSVLAPYL------------PPKHEYVVY 732
                    .||.:..|                   ::.:|.|:|            |||.|.|||
Human   451 SEFTDEGFFEGKLPSRKDLYDIRPYENTYLLKLHTNFEILTPFLLRRLKSDVALEVPPKREVVVY 515

  Fly   733 TTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSN 797
            ..||:.|:..|                                            ..|..|.::|
Human   516 APLSKKQEIFY--------------------------------------------TAIVNRTIAN 536

  Fly   798 DDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGG-GDSDSDL 861
                |.|....||.|                       .:.:|:.|:|..::.|... .|..::|
Human   537 ----MFGSSEKETIE-----------------------LSPTGRPKRRTRKSINYSKIDDFPNEL 574

  Fly   862 EMLGGLGGGSSVQKDDPSEWWKPFVE-----ERELN----------------------------- 892
            |.|     .|.:|.:...|  :..||     |.|:|
Human   575 EKL-----ISQIQPEVDRE--RAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQ 632

  Fly   893 -------NVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDV 950
                   .|.:|.|.|||.|:|.:.:..|.|:|:|||....||::..:..|.|.|
Human   633 EFKIDEELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFN---------- 687

  Fly   951 GDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIF 1015
                        :.|||||.|..:||.....||  |:....:||:|||||||||||.||:.|:|:
Human   688 ------------FSRLDGSMSYSEREKNMHSFN--TDPEVFIFLVSTRAGGLGINLTAADTVIIY 738

  Fly  1016 DVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQ------- 1073
            |..|||..|.|:..|.:|.||.||..:|||:...|::||:.||..||:...|.:|.:.
Human   739 DSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQS 803

  Fly  1074 --QISRHY-NQTDLMEL-----YSYELKPSTEREMPILPKDRLFAEILTEHEKLI 1120
              .:|::: :..:||||     |..|:|.|  ||..|..||   .|:|.:...||
Human   804 GLNLSKNFLDPKELMELLKSRDYEREIKGS--REKVISDKD---LELLLDRSDLI 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	57/248 (23%)
		HepA	<382..1071	CDD:440319	193/813 (24%)
		DEXHc_ATRX	455..699	CDD:350826	59/257 (23%)
HELLS	NP_001275996.1	DEXHc_HELLS_SMARCA6	220..499	CDD:350767	69/329 (21%)
		PLN03142	221..>869	CDD:215601	193/791 (24%)