Protein Alignment XNP and Atrx

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_038955386.1
• Gene: Atrx / 246284
• RGDID: 619795
• Length: 2481
• Species: Rattus norvegicus
• Alignment Length: 1462
• Identity: 537/1462 - (36%)
• Similarity: 763/1462 - (52%)
• Gaps: 236/1462 - (16%)

  Fly    20 DDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHK----------------------NVKA 62
            |....:.||.||....|..|..|...|..|::...|:.|                      |.|.
  Rat  1073 DKKTRNRVSLREKKQFSLPAKSSGKRPECSSSDTERSVKGECCDSTDKRVKRIDLRERRSSNSKR 1137

  Fly    63 SGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSR------------- 114
            |.|...|.||.||   |..|:.|.:|:.  |.|:...:|   :..||||..:
  Rat  1138 STKEVKSGSSSSD---AEGSSEDAKKQK--KQRMSAKKK---TGNTKERKRKSLRATTTKRKQAD 1194

  Fly   115 --------GSQQKNVTINDSSDEEPLK--GSKLVLPAR----KSRNKNA---SIIELSDSEEVDE 162
                    |...:|....:||||:.:|  ...||||:.    :|....|   |:....|.::.|.
  Rat  1195 ITSSSSDIGDDDQNSAGEESSDEQKIKPVTENLVLPSHTGFCQSSGDEAFSKSVPATVDDDDDDN 1259

  Fly   163 EEESLLVAIPLPKE--AQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSS 225
            :.|:.:....|.:|  |..:..|..||....|..||::..::...|........||
  Rat  1260 DPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGEKKRIGKQSEETPGDDGSNQVN--------- 1315

  Fly   226 ERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRS-KSES 289
              |...|.|.....||.:..::|.| :||...:..::.|....:.:|.     |.|.||. .||.
  Rat  1316 --SESDSDSEESKKPRYRHRLLRHK-LSLSDGESGEEKKTKPKEHKET-----KGRNRRKVSSED 1372

  Fly   290 EADSDYEAPAAEEE----EEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEK 350
            ..|:|::.....||    |:|:|..:...::|....:.....|:|:||:....:..|||   .:.
  Rat  1373 SEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSD---NKS 1434

  Fly   351 QKKKGRKRIKKTSSGESDGDGDDDKQKNK-RKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQ 414
            ..::.||........|.:.:.||.|...| ||.||||:|...|...|:.|.|||::|||||.:|:
  Rat  1435 HSEEERKDDDDEEDEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERE 1499

  Fly   415 KLYNRIFVKSESVEINE-----------LVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWD 468
            :...::   .|.:||.:           ||||.|||:|:.|:||.:.::.|||||||.||:||||
  Rat  1500 REREKL---REVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWD 1561

  Fly   469 ACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWARE 533
            .|.|::|::::.||||||||||||||||||||:..||:|: ..:......|::.||:|..||..|
  Rat  1562 CCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLL-CDKLDFSTALVVCPLNTALNWMNE 1625

  Fly   534 FTSWMKFAN-RNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILA---NEKAKGLRK 594
            |..|.:..| ...:||.:::..|....|.:.|..|..:|||.|:||:|||.||   |.|:    :
  Rat  1626 FEKWQEGLNDAEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKS----R 1686

  Fly   595 KQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQ 659
            |.:|...:||||||||.|||||||:||||.:::|||:..::::|||:||||||||||.||:||:.
  Rat  1687 KLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVN 1751

  Fly   660 FVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLP 724
            |:|.||||:.||:.|||:|||.|||..|||..|:|:||.|:|||:::|.||:||:||:.|..:||
  Rat  1752 FIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLP 1816

  Fly   725 PKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVG----KGARLFQDFQDLRRIWTHPMNLRVN 785
            ||||||:...::.:|.|||.||: .|....|....|    .||:||||||.|.||||||..|::
  Rat  1817 PKHEYVLAVRMTAIQCKLYQYYL-DHLTGVGNSTDGGRGKAGAKLFQDFQMLSRIWTHPWCLQL- 1879

  Fly   786 SDNVIAKRLLSNDDSDMEGFICDETDE-------DEAASNSSDSCETFKSDASMSGLAASSGKVK 843
             |.:..:.....|:..|:.||..::||       ||.|.......:..:.|:|.|| :.|...|:
  Rat  1880 -DYISKENKGYFDEDSMDEFIASDSDETSMSLSSDEYAKKKKTKGKKGRKDSSSSG-SGSDNDVE 1942

  Fly   844 KRKTRNGNAGGGDSDSDLEMLGG-------LGGGSSVQKDDPS----EWWKPFVEERELNNVHHS 897
            ..|..|..:.|| .:.::|..|.       |....:....:||    :|:|.||.:.:...:.||
  Rat  1943 VIKVWNSRSRGG-GEGNVEETGNNPSVSLKLDESKTTSTSNPSSPAPDWYKDFVTDADAEVLEHS 2006

  Fly   898 PKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSL-----VDSNTKNYEFEGDVGDFKGCW 957
            .|:::|..:|:..|.||||:|||||||.|||:||.||.|     .:...|...::|:     |.|
  Rat  2007 GKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGE-----GKW 2066

  Fly   958 TSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPS 1022
            ....||:|||||.:.:.|:...::||:.||:|.|||:|||:||.|||||||||||:|||.|||||
  Rat  2067 LRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPS 2131

  Fly  1023 HDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMEL 1087
            :|.|||||||||||.||.|:||.:|.||||.|:|:|||.||:.:.||:|:||:.||:...:|.||
  Rat  2132 YDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTEL 2196

  Fly  1088 YSYEL----KPSTE----REMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERK 1144
            |::|.    .|::|    |:.|:||||.:.||:|..|::.|..||||||||:.:|.|.|||||||
  Rat  2197 YTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERK 2261

  Fly  1145 SAWAEYEAEK------------------TRTVQASQYMSYD---RNAFGNQVMGQFGN------- 1181
            :|||||||||                  |.|.| :.|:.::   .:|..||.:....|
  Rat  2262 AAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQ-TPYIPFNLGALSAMSNQQLEDLINQGREKVV 2325

  Fly  1182 -ASGSVTSNKIFGFRSDILLQLL--NMKISKDH-----------QELN--------------QNQ 1218
             |:.||||.:|... .||:..:.  ||.:|:..           |||:              |..
  Rat  2326 EATNSVTSVRIQPL-EDIISTVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQM 2389

  Fly  1219 VIQ-----LVPTYLQQLYNEMNNGDPTMYKDLLNLHSNIVHPSGMYMNPLLYANQNPNAAG-YNQ 1277
            :|.     |:...|||.|.:......| |:.....|..:..|..:.|.|..|  |..:..| |..
  Rat  2390 LISCVQRILMNRRLQQQYTQQQQQQLT-YQQATLSHLMMPKPPNLIMTPSNY--QQIDMRGMYQS 2451

  Fly  1278 GTGGV--PPMAGGSVAHGPP------AAPAPG 1301
            ..||:  ||:     ...||      ..|:||
  Rat  2452 VAGGMQPPPL-----QRAPPPMRSKNPGPSPG 2478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	89/305 (29%)
		HepA	<382..1071	CDD:440319	338/730 (46%)
		DEXHc_ATRX	455..699	CDD:350826	132/247 (53%)
Atrx	XP_038955386.1	ADDz_ATRX	176..279	CDD:277252
		HepA	<1531..2180	CDD:440319	313/663 (47%)
		DEXHc_ATRX	1548..1791	CDD:350826	132/247 (53%)