DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and Atrx

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	XP_038955386.1	Gene:	Atrx / 246284	RGDID:	619795	Length:	2481	Species:	Rattus norvegicus

Alignment Length:	1462	Identity:	537/1462 - (36%)
Similarity:	763/1462 - (52%)	Gaps:	236/1462 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHK----------------------NVKA 62
            |....:.||.||....|..|..|...|..|::...|:.|                      |.|.
  Rat  1073 DKKTRNRVSLREKKQFSLPAKSSGKRPECSSSDTERSVKGECCDSTDKRVKRIDLRERRSSNSKR 1137

  Fly    63 SGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSR------------- 114
            |.|...|.||.||   |..|:.|.:|:.  |.|:...:|   :..||||..:
  Rat  1138 STKEVKSGSSSSD---AEGSSEDAKKQK--KQRMSAKKK---TGNTKERKRKSLRATTTKRKQAD 1194

  Fly   115 --------GSQQKNVTINDSSDEEPLK--GSKLVLPAR----KSRNKNA---SIIELSDSEEVDE 162
                    |...:|....:||||:.:|  ...||||:.    :|....|   |:....|.::.|.
  Rat  1195 ITSSSSDIGDDDQNSAGEESSDEQKIKPVTENLVLPSHTGFCQSSGDEAFSKSVPATVDDDDDDN 1259

  Fly   163 EEESLLVAIPLPKE--AQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSS 225
            :.|:.:....|.:|  |..:..|..||....|..||::..::...|........||
  Rat  1260 DPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGEKKRIGKQSEETPGDDGSNQVN--------- 1315

  Fly   226 ERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRS-KSES 289
              |...|.|.....||.:..::|.| :||...:..::.|....:.:|.     |.|.||. .||.
  Rat  1316 --SESDSDSEESKKPRYRHRLLRHK-LSLSDGESGEEKKTKPKEHKET-----KGRNRRKVSSED 1372

  Fly   290 EADSDYEAPAAEEE----EEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEK 350
            ..|:|::.....||    |:|:|..:...::|....:.....|:|:||:....:..|||   .:.
  Rat  1373 SEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSD---NKS 1434

  Fly   351 QKKKGRKRIKKTSSGESDGDGDDDKQKNK-RKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQ 414
            ..::.||........|.:.:.||.|...| ||.||||:|...|...|:.|.|||::|||||.:|:
  Rat  1435 HSEEERKDDDDEEDEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERE 1499

  Fly   415 KLYNRIFVKSESVEINE-----------LVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWD 468
            :...::   .|.:||.:           ||||.|||:|:.|:||.:.::.|||||||.||:||||
  Rat  1500 REREKL---REVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWD 1561

  Fly   469 ACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWARE 533
            .|.|::|::::.||||||||||||||||||||:..||:|: ..:......|::.||:|..||..|
  Rat  1562 CCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLL-CDKLDFSTALVVCPLNTALNWMNE 1625

  Fly   534 FTSWMKFAN-RNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILA---NEKAKGLRK 594
            |..|.:..| ...:||.:::..|....|.:.|..|..:|||.|:||:|||.||   |.|:    :
  Rat  1626 FEKWQEGLNDAEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKS----R 1686

  Fly   595 KQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQ 659
            |.:|...:||||||||.|||||||:||||.:::|||:..::::|||:||||||||||.||:||:.
  Rat  1687 KLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVN 1751

  Fly   660 FVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLP 724
            |:|.||||:.||:.|||:|||.|||..|||..|:|:||.|:|||:::|.||:||:||:.|..:||
  Rat  1752 FIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLP 1816

  Fly   725 PKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVG----KGARLFQDFQDLRRIWTHPMNLRVN 785
            ||||||:...::.:|.|||.||: .|....|....|    .||:||||||.|.||||||..|::
  Rat  1817 PKHEYVLAVRMTAIQCKLYQYYL-DHLTGVGNSTDGGRGKAGAKLFQDFQMLSRIWTHPWCLQL- 1879

  Fly   786 SDNVIAKRLLSNDDSDMEGFICDETDE-------DEAASNSSDSCETFKSDASMSGLAASSGKVK 843
             |.:..:.....|:..|:.||..::||       ||.|.......:..:.|:|.|| :.|...|:
  Rat  1880 -DYISKENKGYFDEDSMDEFIASDSDETSMSLSSDEYAKKKKTKGKKGRKDSSSSG-SGSDNDVE 1942

  Fly   844 KRKTRNGNAGGGDSDSDLEMLGG-------LGGGSSVQKDDPS----EWWKPFVEERELNNVHHS 897
            ..|..|..:.|| .:.::|..|.       |....:....:||    :|:|.||.:.:...:.||
  Rat  1943 VIKVWNSRSRGG-GEGNVEETGNNPSVSLKLDESKTTSTSNPSSPAPDWYKDFVTDADAEVLEHS 2006

  Fly   898 PKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSL-----VDSNTKNYEFEGDVGDFKGCW 957
            .|:::|..:|:..|.||||:|||||||.|||:||.||.|     .:...|...::|:     |.|
  Rat  2007 GKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGE-----GKW 2066

  Fly   958 TSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPS 1022
            ....||:|||||.:.:.|:...::||:.||:|.|||:|||:||.|||||||||||:|||.|||||
  Rat  2067 LRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPS 2131

  Fly  1023 HDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMEL 1087
            :|.|||||||||||.||.|:||.:|.||||.|:|:|||.||:.:.||:|:||:.||:...:|.||
  Rat  2132 YDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTEL 2196

  Fly  1088 YSYEL----KPSTE----REMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERK 1144
            |::|.    .|::|    |:.|:||||.:.||:|..|::.|..||||||||:.:|.|.|||||||
  Rat  2197 YTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERK 2261

  Fly  1145 SAWAEYEAEK------------------TRTVQASQYMSYD---RNAFGNQVMGQFGN------- 1181
            :|||||||||                  |.|.| :.|:.::   .:|..||.:....|
  Rat  2262 AAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQ-TPYIPFNLGALSAMSNQQLEDLINQGREKVV 2325

  Fly  1182 -ASGSVTSNKIFGFRSDILLQLL--NMKISKDH-----------QELN--------------QNQ 1218
             |:.||||.:|... .||:..:.  ||.:|:..           |||:              |..
  Rat  2326 EATNSVTSVRIQPL-EDIISTVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQM 2389

  Fly  1219 VIQ-----LVPTYLQQLYNEMNNGDPTMYKDLLNLHSNIVHPSGMYMNPLLYANQNPNAAG-YNQ 1277
            :|.     |:...|||.|.:......| |:.....|..:..|..:.|.|..|  |..:..| |..
  Rat  2390 LISCVQRILMNRRLQQQYTQQQQQQLT-YQQATLSHLMMPKPPNLIMTPSNY--QQIDMRGMYQS 2451

  Fly  1278 GTGGV--PPMAGGSVAHGPP------AAPAPG 1301
            ..||:  ||:     ...||      ..|:||
  Rat  2452 VAGGMQPPPL-----QRAPPPMRSKNPGPSPG 2478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	20/81 (25%)
		SNF2_N	458..779	CDD:278600	171/328 (52%)
		DEXDc	483..646	CDD:238005	80/166 (48%)
		Helicase_C	913..1035	CDD:278689	72/126 (57%)
Atrx	XP_038955386.1	ADDz_ATRX	176..279	CDD:277252
		HepA	<1523..2174	CDD:223627	316/665 (48%)
		DEXHc_ATRX	1548..1791	CDD:350826	132/247 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111318at33208
OrthoFinder	1	1.000	-	-		FOG0003310
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104269
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840