Protein Alignment XNP and Ercc6l

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_666347.2
• Gene: Ercc6l / 236930
• MGIID: 2654144
• Length: 1240
• Species: Mus musculus
• Alignment Length: 1020
• Identity: 245/1020 - (24%)
• Similarity: 407/1020 - (39%)
• Gaps: 325/1020 - (31%)

  Fly   397 KEAAKEEDDRRKRIEDRQKLYN---RIF----VKSESVEINELVLDF-DEESKKALLQV-DKGLL 452
            |||||..|     :|:..||:|   .||    |.|...::.|.:... :||.....:.| ..|||
Mouse    29 KEAAKNGD-----LEESLKLFNLAKDIFPTKKVMSRIQKLQEALEQLAEEEDDDEFIDVCSSGLL 88

  Fly   453 ------KKLKPHQVAGVKFMWDACFETLKESQEKPG-SGCILAHCMGLGKTLQVVT----LSHTL 506
                  :||..||..|:.|::         |..|.| .|.|||..||||||:|::.    :....
Mouse    89 LYRELYEKLFEHQKEGIAFLY---------SLYKDGRKGGILADDMGLGKTVQIIAFLSGMFDAS 144

  Fly   507 LVNTRRTGVDRVLIISPLSTVNNWAREFTSW---MKFANRNDIEVYDISRYKDKPTRIFKLNEWF 568
            |||       .||:|.|.:.:|.|..||..|   |:      ::.:..|...::...:.::.:
Mouse   145 LVN-------HVLLIMPTNLINTWVNEFAKWTPGMR------VKTFHGSSKSERTRSLTRIQQ-- 194

  Fly   569 NEGGVCILGYDMYRILANEKAKGLRKKQREQLM----QALVDPGPDLVVCDEGHLLKNEKTSISK 629
             ..||.|..|.|  :|.|          .:||.    ||.|   .|.|:.||.|.:|:..|..:.
Mouse   195 -RNGVVITTYQM--LLNN----------WQQLASFNGQAFV---WDYVILDEAHKIKSASTKSAV 243

  Fly   630 AVTRMRTKRRIVLTGTPLQNNLREYYCMIQFV-KPNLLGTYKEYMNRFVNPITNGQYTDST--ER 691
            ....:....|::|||||:||||:|.:.:..|. :.:||||.|.:...:.:||...:..|:|  |:
Mouse   244 CARAIPASNRLLLTGTPVQNNLQELWSLFDFACQGSLLGTLKTFKMEYEHPIIRAREKDATPGEK 308

  Fly   692 DLRLMKHRSHILHKLLEGCIQRRDYSVLAPY---------------------------------- 722
            .|.|         |:.|..::     ::.||
Mouse   309 ALGL---------KISENLME-----IIKPYFLRRTKEEVQTKKADNPEARLGEKNPAGEAICDM 359

  Fly   723 --LPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVN 785
              |..|::.:|:..|..||:::|..:::....:   :::.:......:...|:::..||..|...
Mouse   360 FSLARKNDLIVWIRLLPLQEEIYRKFVSLDHIK---ELLMETRSPLAELGVLKKLCDHPRLLSAR 421

  Fly   786 SDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNG 850
                 |.|||:...:.   |...:.:|.|..||
Mouse   422 -----ACRLLNLGTAT---FSAQDENEQEDVSN-------------------------------- 446

  Fly   851 NAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSP---------KLLILLRL 906
                                                    :|::.|.|         |::.|:.|
Mouse   447 ----------------------------------------MNSIDHLPDKTLIQESGKMIFLMSL 471

  Fly   907 LQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCS 971
            |::.:..|.:.||||||::.|::||..|       ||..|:               ..|:||:.:
Mouse   472 LERLQDEGHQTLVFSQSIKILNIIERLL-------KNKHFK---------------TLRIDGTVT 514

  Fly   972 -VEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFG 1035
             :.:||...:.|..  |....:||::|:.||:|:.|.||.||||||.||||:.|.|::.||||.|
Mouse   515 HLWEREKRIQLFQQ--NKEYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIG 577

  Fly  1036 QIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQIS-RHYNQTDLMELYSY-EL-KPSTE 1097
            |.:...:||||..||:|:|:|.|||.|.:..::...|::.. |::.:.:|.||::. :| |.:|:
Mouse   578 QKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFTKQELKELFTVGDLQKSATQ 642

  Fly  1098 REMPIL-PKDRLFAEILTEHEKLIFKYH--------EHDSL----LEQEEHENLTEEERKSAWAE 1149
            .::..| ...|...|.|.||   |...|        :||.:    |..:|..::.|:      ::
Mouse   643 MQLQCLHAAQRRSDEKLDEH---IAYLHLLGIAGISDHDLMFTRDLSVKEELDMLED------SQ 698

  Fly  1150 YEAEKTRTVQASQYM--SYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQ 1212
            |..::   ||.:|::  |..:|....|..|.      ..|..|...|.|         :..|...
Mouse   699 YIHQR---VQKAQFLVESESQNTVQRQTTGI------EETWLKAQEFPS---------QQKKKGT 745

  Fly  1213 ELN--QNQVIQLV--PTYLQQLYNEMNN---------GDPTMYKDLLNL-------HSNIVHPSG 1257
            |.|  |.|..:|:  ||.::.:.::|.:         .:|..:.::.::       |.|....:|
Mouse   746 EFNKPQPQPSRLLTKPTQVEAISSQMASITICDQSAESEPQEHSEVHDVTSLQGSHHFNSTSDAG 810

  Fly  1258 MYMNPLLYANQNPNAAGYNQGTGGVPPMAGGSVAHGPPAAPAPGF 1302
                         ..|...||...:     |.|:.....:||.||
Mouse   811 -------------TIASLPQGAESI-----GEVSTDSLLSPAKGF 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	24/77 (31%)
		HepA	<382..1071	CDD:440319	190/749 (25%)
		DEXHc_ATRX	455..699	CDD:350826	76/258 (29%)
Ercc6l	NP_666347.2	TPR 1	21..54		12/29 (41%)
		HepA	<96..613	CDD:440319	169/677 (25%)
		DEXHc_ERCC6L	97..329	CDD:350759	80/285 (28%)
		DEAH box	229..232		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..760		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..813		4/47 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..879
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..1085
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1104..1185
		TPR 2	1191..1224