DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XNP and Atrx

DIOPT Version :9

Sequence 1:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_033556.2	Gene:	Atrx / 22589	MGIID:	103067	Length:	2476	Species:	Mus musculus

Alignment Length:	1442	Identity:	531/1442 - (36%)
Similarity:	771/1442 - (53%)	Gaps:	222/1442 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SVSRRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEP 90
            |.|..|.:.:.:....:|..|.|.:.:: |.:.:.|.:.|...|:||.||   |..|:.|.:|:
Mouse  1088 SSSDTEKSLKGQCCDSTEKRPKRIDLRE-RRNSSSKRNTKEVKSASSSSD---AEGSSEDNKKQ- 1147

  Fly    91 VCKIRIVPLEKLLASPKTKER------PSR------------GSQQKNVTINDSSDEEPLK--GS 135
              |.:....:|...:.|.|:|      |.|            |...:|....:||||:.:|  ..
Mouse  1148 --KKQRTSAKKKTGNTKEKKRNSLRATPKRKQVDITSSSSDIGDDDQNSAGEESSDEQKIKPVTE 1210

  Fly   136 KLVLPAR----KSRNKNA---SIIELSDSEEVDEEEESLLVAIPLPKE--AQQTKPEKNSSK--- 188
            .||||:.    :|....|   |:....|.::.|.:.|:.:....|.:|  |..:..|..||.
Mouse  1211 NLVLPSHTGFCQSSGDEALSKSVPATVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEP 1275

  Fly   189 --ASKESIEKRQKAQKEATTSSAR----AIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVV 247
              ..|:.|.| |..:..|.....|    |:..||           |...|.|.....||.:..::
Mouse  1276 DGGGKKRIGK-QSEESPADDGELRREQLAVNQVN-----------SESDSDSEESKKPRYRHRLL 1328

  Fly   248 RLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEE----EEEER 308
            |.|..........:||.|.....|     :|...:|:..||...|:|::.....||    |:|:|
Mouse  1329 RHKLTLSDGESGEEKPTKPKEHKE-----AKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQR 1388

  Fly   309 KSSGDEEEAANSSDSEVMPQRKRRRK-KSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGD 372
            ..:...::|....:.....|:|:||: |.:.|..|.:....|:.||:|.:..::....:.:.:.|
Mouse  1389 PRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSHSEEDKKEGDEEDEEDEDEDEEDEND 1453

  Fly   373 DDKQKNK-RKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINE----- 431
            |.|...| ||.||||:|...|...|:.|.|||::|||||.:|::...::   .|.:||.:
Mouse  1454 DSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKL---REVIEIEDASPTK 1515

  Fly   432 ------LVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHC 490
                  ||||.:||:|:.|:||.:.::.|||||||.||:||||.|.|:::::::.||||||||||
Mouse  1516 CPITTKLVLDENEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHC 1580

  Fly   491 MGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRND-IEVYDISRY 554
            ||||||||||:..||:|: ..:......|::.||:|..||..||..|.:..|.|: :||.:::..
Mouse  1581 MGLGKTLQVVSFLHTVLL-CDKLDFSTALVVCPLNTALNWMNEFEKWQEGLNDNEKLEVSELATV 1644

  Fly   555 KDKPTRIFKLNEWFNEGGVCILGYDMYRILA---NEKAKGLRKKQREQLMQALVDPGPDLVVCDE 616
            |....|.:.|..|..:|||.|:||:|||.||   |.|:    :|.::...:||||||||.|||||
Mouse  1645 KRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKS----RKLKDIFNKALVDPGPDFVVCDE 1705

  Fly   617 GHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPIT 681
            ||:||||.:::|||:..::::|||:||||||||||.||:||:.|:|.||||:.||:.|||:|||.
Mouse  1706 GHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQ 1770

  Fly   682 NGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYY 746
            |||..|||..|:|:||.|:|||:::|.||:||:||:.|..:||||||||:...::.:|.|||.||
Mouse  1771 NGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTAIQCKLYQYY 1835

  Fly   747 MTTHREQSGGDVVG----KGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFIC 807
            : .|....|....|    .||:||||||.|.||||||..|::  |.:..:.....|:..|:.||.
Mouse  1836 L-DHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQL--DYISKENKGYFDEDSMDEFIA 1897

  Fly   808 DETDEDEAASNSSD----SCETFKSDASMSGLAASSGKVKKRKTRNGNA-GGGDSDSDLEMLGGL 867
            .::||...:.:|.:    ..:..|.|:|.|| :.|...|:..|..|..: ||||.:.|     ..
Mouse  1898 SDSDETSKSLSSDEKKKPKGKKGKKDSSSSG-SGSDNDVEVIKVWNSRSRGGGDGNVD-----DT 1956

  Fly   868 GGGSSV----------QKDDPS----EWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLL 918
            |...||          ...:||    :|:|.||.:.:...:.||.|:::|..:|:..|.||||:|
Mouse  1957 GNNPSVSLKLDESKTTSTSNPSSPAPDWYKDFVTDTDAEVLEHSGKMVLLFEILRMAEEIGDKVL 2021

  Fly   919 VFSQSLQSLDVIEHFLSLVD-SNTKNYE----FEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAM 978
            ||||||.|||:||.||.|.. ..|::.|    ::|:     |.|....||:|||||.:.:.|:..
Mouse  2022 VFSQSLISLDLIEDFLELASREKTEDKEKPLIYKGE-----GKWIRNIDYYRLDGSTNAQSRKKW 2081

  Fly   979 CKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIY 1043
            .::||:.||:|.|||:|||:||.|||||||||||:|||.|||||:|.|||||||||||.||.|:|
Mouse  2082 AEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVY 2146

  Fly  1044 RLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYEL----KPSTE----REM 1100
            |.:|.||||.|:|:|||.||:.:.||:|:||:.||:...:|.|||::|.    .|::|    |:.
Mouse  2147 RFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDT 2211

  Fly  1101 PILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEK----------- 1154
            |:||||.:.||:|..|::.|..||||||||:.:|.|.|||||||:|||||||||
Mouse  2212 PMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPT 2276

  Fly  1155 -------TRTVQASQYMSYD---RNAFGNQVMGQFGN--------ASGSVTSNKIFGFRSDILLQ 1201
                   |.|.| :.|:.::   .:|..||.:....|        |:.|:|:.:|... .||:..
Mouse  2277 GTNLPPVTFTSQ-TPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSMTAVRIQPL-EDIIST 2339

  Fly  1202 LL--NMKISKDH-----------QELN--------------QNQVIQ-----LVPTYLQQLYNEM 1234
            :.  ||.:|:..           |||:              |..:|.     |:...|||.|.:.
Mouse  2340 VWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLINCVQRILMNRRLQQQYTQQ 2404

  Fly  1235 NNGDPTMYKDLLNLHSNIVHPSGMYMNPLLYANQNPNAAG-YNQGTGGV--PPMAGGSVAHGPP- 1295
            .....| |:.....|..:..|..:.|.|..|  |..:..| |....||:  ||:     ...||
Mouse  2405 QQQQLT-YQQATLSHLMMPKPPNLIMTPSNY--QQIDMRGMYQSVAGGMQPPPL-----QRAPPP 2461

  Fly  1296 ------AAPAPG 1301
                  ..|:||
Mouse  2462 TVRSKNPGPSPG 2473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	20/81 (25%)
		SNF2_N	458..779	CDD:278600	170/328 (52%)
		DEXDc	483..646	CDD:238005	80/166 (48%)
		Helicase_C	913..1035	CDD:278689	73/126 (58%)
Atrx	NP_033556.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..154
		ADDz_ATRX	166..269	CDD:277252
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..507
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..568
		PxVxL motif	573..586
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..877
		DTHCT	727..820	CDD:285332
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	893..1464		96/399 (24%)
		PIEZO	<914..1004	CDD:292539
		Interaction with DAXX. /evidence=ECO:0000250	1169..1313		35/155 (23%)
		SNF2_N	1548..1874	CDD:278600	172/331 (52%)
		DEXDc	1573..1735	CDD:238005	80/166 (48%)
		DEGH box	1704..1707		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1898..1982		22/89 (25%)
		Interaction with MECP2. /evidence=ECO:0000250	1993..2263		146/274 (53%)
		HELICc	2000..2146	CDD:238034	84/150 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2445..2476		9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839442
Domainoid	1	1.000	314	1.000	Domainoid score	I1294
eggNOG	1	0.900	-	-		E2759_KOG1015
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5042
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111318at33208
OrthoFinder	1	1.000	-	-		FOG0003310
OrthoInspector	1	1.000	-	-		oto93554
orthoMCL	1	0.900	-	-		OOG6_104269
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4866
SonicParanoid	1	1.000	-	-		X2684
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.590