DRSC/TRiP Functional Genomics Resources

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Protein Alignment XNP and ERCC6

DIOPT Version :10

Sequence 1:NP_651398.1 Gene:XNP / 43080 FlyBaseID:FBgn0039338 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_000115.1 Gene:ERCC6 / 2074 HGNCID:3438 Length:1493 Species:Homo sapiens


Alignment Length:1256 Identity:295/1256 - (23%)
Similarity:505/1256 - (40%) Gaps:375/1256 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 VSSSSDSDQAVANSSANDEEKE--------PVCKIRIVPLEKLL--ASPKT-------------- 108
            :..:|.:.|.|      |.|||        ..|...:..:.|::  .||:.              
Human   117 IHEASRASQLV------DVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVK 175

  Fly   109 KERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAI-- 171
            :::.::..|.|.:|......:..|.|:::     |....:||:.|  |:|.......|:|:.:  
Human   176 RQKYNKEQQLKKITAKQKHLQAILGGAEV-----KIELDHASLEE--DAEPGPSSLGSMLMPVQE 233

  Fly   172 ----PLPKEAQQTK-----PEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSER 227
                .|.:..|.|.     |:|...|..|..:.:....:|....             :..||.||
Human   234 TAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLAD-------------QAKLSFER 285

  Fly   228 SSRASSSRAE-------SPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRR- 284
            ..:..:.||.       :||.|.:          .|.||.:|.:.:|...|......||.::|. 
Human   286 KKQGCNKRAARKAPAPVTPPAPVQ----------NKNKPNKKARVLSKKEERLKKHIKKLQKRAL 340

  Fly   285 ------------------SKSESEADSDYEA----PAAEEEEEEERKSSGDEEE-AANSSDSEVM 326
                              .:.|:|.||:.|.    |..||||||:.:..|.|.: :.:.:|.|:.
Human   341 QFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGTDYELK 405

  Fly   327 PQRK--RRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDG----------DGDDDKQKNK 379
            |..|  :|:||....:...||.|...::.:.      .|.||..|          |||:|..|.:
Human   406 PLPKGGKRQKKVPVQEIDDDFFPSSGEEAEA------ASVGEGGGGGRKVGRYRDDGDEDYYKQR 464

  Fly   380 RKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKAL 444
            .:...|:                      |::|::|   |:.::.:|.|.:   .:|||..|   
Human   465 LRRWNKL----------------------RLQDKEK---RLKLEDDSEESD---AEFDEGFK--- 498

  Fly   445 LQVDKGLLKKLKPHQVAGVKFMWDA-CFETLKESQEKPGSGCILAHCMGLGKTLQVVT----LSH 504
              |...|.|||..:|..||:::|:. |.:          :|.||...||||||:|::.    ||:
Human   499 --VPGFLFKKLFKYQQTGVRWLWELHCQQ----------AGGILGDEMGLGKTIQIIAFLAGLSY 551

  Fly   505 TLL----VNTRRTGVDRVLIISPLSTVNNWAREF-TSWMKFANRNDIEVYDISRYKDKPTRIFKL 564
            :.:    .|.|..|:...:|:.|.:.::.|.:|| |.|..|  |..| :::...|..|..::  :
Human   552 SKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTWWPPF--RVAI-LHETGSYTHKKEKL--I 611

  Fly   565 NEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPD--LVVCDEGHLLKNEKTSI 627
            .:..:..|:.|..|...|::.::.::                  .|  .|:.||||.::|...::
Human   612 RDVAHCHGILITSYSYIRLMQDDISR------------------YDWHYVILDEGHKIRNPNAAV 658

  Fly   628 SKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERD 692
            :.|..:.||..||:|:|:|:||||||.:.:..|:.|..|||...:|.:|..|||.|.|::::...
Human   659 TLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQ 723

  Fly   693 LRLMKHRSHILHKLLEGCIQRRDYS--VLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSG 755
            ::.....:.:|...:...:.||..|  .::..||.|:|.|::..|::.|.|:|..::.:..... 
Human   724 VKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYR- 787

  Fly   756 GDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSS 820
              ::....::|.....||:|..||             .|.|....:::|...||.:||:..    
Human   788 --ILNGEMQIFSGLIALRKICNHP-------------DLFSGGPKNLKGLPDDELEEDQFG---- 833

  Fly   821 DSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPF 885
                                                                        :||  
Human   834 ------------------------------------------------------------YWK-- 836

  Fly   886 VEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDV 950
                      .|.|::::..||:.....|.::|:||||.|.||::|.||     ..:.|      
Human   837 ----------RSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFL-----RAQKY------ 880

  Fly   951 GDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIF 1015
                       .|.::||:.::..|:.:..::|..|::  .:||::||.||||:||..||||||:
Human   881 -----------TYLKMDGTTTIASRQPLITRYNEDTSI--FVFLLTTRVGGLGVNLTGANRVVIY 932

  Fly  1016 DVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYN 1080
            |..||||.|||:..|.:|.||.|...:|||:..||:|:|:|.||:.||....||:.:.:..|.:.
Human   933 DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFK 997

  Fly  1081 QTDLMELY---SYELKPSTE---------------------REMPI------LPKDRLFA----- 1110
            ..||.||:   |.:...|||                     |..|.      :||.:.|.     
Human   998 SNDLYELFTLTSPDASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNIS 1062

  Fly  1111 --EILTEHEKLIFKYHEHDSL-------LEQEEH--ENLTEEERKSAWAEYEAEKTRTVQASQYM 1164
              :..:..||...|..|.:::       |:.:.|  .|:|..:|.       .|:|..|...:.:
Human  1063 VNDATSSEEKSEAKGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRL-------GEETNAVSGPEEL 1120

  Fly  1165 SYDRNAFGNQVMGQFGNASGS 1185
            |.   ..||   |:..|:||:
Human  1121 SV---ISGN---GECSNSSGT 1135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XNPNP_651398.1 PTZ00121 <173..>460 CDD:173412 75/334 (22%)
HepA <382..1071 CDD:440319 179/702 (25%)
DEXHc_ATRX 455..699 CDD:350826 70/255 (27%)
ERCC6NP_000115.1 N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878 1..510 99/467 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
cc_ERCC-6_N 83..159 CDD:411064 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..323 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..453 28/114 (25%)
HepA 391..987 CDD:440319 198/783 (25%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 646..649 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1042..1147 23/107 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1247
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1318..1384
CSA-interacting motif (CIM). /evidence=ECO:0000269|PubMed:32355176 1386..1398
Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997 1400..1428
CSB_WHD 1420..1492 CDD:439329
Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878 1429..1493
Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705 1446..1493
Blue background indicates that the domain is not in the aligned region.

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