Protein Alignment XNP and Smarca4

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_011240739.1
• Gene: Smarca4 / 20586
• MGIID: 88192
• Length: 1670
• Species: Mus musculus
• Alignment Length: 1323
• Identity: 299/1323 - (22%)
• Similarity: 479/1323 - (36%)
• Gaps: 416/1323 - (31%)

  Fly     6 PNARHTDAATPLTTDDS--NSSSVSRRESATESKSASESESSPPRSNT---------------KQ 53
            |.....:||.|.:|...  ......|...|..:...:.|...||::.:               ||
Mouse   305 PEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPLVPLHQKQ 369

  Fly    54 SRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQ 118
            ||.....|..|...|....:.:..:....|:          ||..||.|..|       ..|..:
Mouse   370 SRITPIQKPRGLDPVEILQEREYRLQARIAH----------RIQELENLPGS-------LAGDLR 417

  Fly   119 KNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEV------DEEEESLLVAIPLPKEA 177
            ...||.       ||..:|:...|:.|            :||      |...|:.|.|    |..
Mouse   418 TKATIE-------LKALRLLNFQRQLR------------QEVVVCMRRDTALETALNA----KAY 459

  Fly   178 QQTKPEKNSSKASKESIEKRQKAQKE------------ATTSSARAIRSVNGTRRGSL------- 223
            :::|.:........|.:||:||.::|            :....|:..|..:.:..|.|
Mouse   460 KRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFREYHRSVTGKLQKLTKAV 524

  Fly   224 -----SSERSSRASSSRAESPPRPKRCVVRLKRV------SLPKTKPAQKPKKMS-----SD--- 269
                 ::||..:..:.|.|..        |::|:      ...|....:|.|:::     :|
Mouse   525 ATYHANTEREQKKENERIEKE--------RMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYV 581

  Fly   270 --------SEEAATTSKKSRQRRSKSESEADSDYEAPA----AEEEEEEERKS------------ 310
                    ..:||..:|:.::::.|.::| :::.:.||    .|..:|..:.|
Mouse   582 ANLTELVRQHKAAQVAKEKKKKKKKKKAE-NAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESG 645

  Fly   311 ---SGDEEEAANSSDS--------EVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSS 364
               :|.:...|...::        ||.|       :|:|::..|:.|.||:::::.:.....|..
Mouse   646 KILTGTDAPKAGQLEAWLEMNPGYEVAP-------RSDSEESGSEEEEEEEEEEQPQPAQPPTLP 703

  Fly   365 GES-----DGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDR-----QKLYNR 419
            .|.     |.|.||..:.:.|..|              |.||::.|....:...     |..|..
Mouse   704 VEEKKKIPDPDSDDVSEVDARHII--------------ENAKQDVDDEYGVSQALARGLQSYYAV 754

  Fly   420 IFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSG 484
            ....:|.|:            |::.|.|: |:||:   :|:.|::::.......|..
Mouse   755 AHAVTERVD------------KQSALMVN-GVLKQ---YQIKGLEWLVSLYNNNLNG-------- 795

  Fly   485 CILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVY 549
             |||..||||||:|.:.|...|:.:.|..|  ..|||.||||::|||.||..|..       .|.
Mouse   796 -ILADEMGLGKTIQTIALITYLMEHKRING--PFLIIVPLSTLSNWAYEFDKWAP-------SVV 850

  Fly   550 DISRYKDKPT--RIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLV 612
            .:| ||..|.  |.|.......:..|.:..|: |.|    |.|.:..|.|.:.|
Mouse   851 KVS-YKGSPAARRAFVPQLRSGKFNVLLTTYE-YII----KDKHILAKIRWKYM----------- 898

  Fly   613 VCDEGHLLKNEKTSISKAV-TRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLL---GTYKEYM 673
            :.||||.:||....:::.: |.....||::||||||||.|.|.:.::.|:.|.:.   .|::::.
Mouse   899 IVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWF 963

  Fly   674 NRFVNPIT-NGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSE 737
            |.   |.. .|:..|..|.:..|:..|   |||:|...:.||....:...||.|.|||:...:|.
Mouse   964 NA---PFAMTGEKVDLNEEETILIIRR---LHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSA 1022

  Fly   738 LQQKLY------GYYMTTHREQSGGDVVGKGA--RLFQDFQDLRRIWTHPMNLRVNSDNVIAKRL 794
            ||:.||      |..:|...|:   |..|||.  .|......||:|..||
Mouse  1023 LQRVLYRHMQAKGVLLTDGSEK---DKKGKGGTKTLMNTIMQLRKICNHP--------------- 1069

  Fly   795 LSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDS 859
                      ::....:|                                              |
Mouse  1070 ----------YMFQHIEE----------------------------------------------S 1078

  Fly   860 DLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSL 924
            ..|.||..||               .|:..:|...  |.|..:|.|:|.:..|...|:|:|.|..
Mouse  1079 FSEHLGFTGG---------------IVQGLDLYRA--SGKFELLDRILPKLRATNHKVLLFCQMT 1126

  Fly   925 QSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLR 989
            ..:.::|.:          :.:.|    ||        |.||||:...|.|..:.|.||. ....
Mouse  1127 SLMTIMEDY----------FAYRG----FK--------YLRLDGTTKAEDRGMLLKTFNE-PGSE 1168

  Fly   990 ARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQK 1054
            ..:||:||||||||:||.:|:.|:|||..|||..|.|:..|.:|.||.....:.||..:.::|:|
Mouse  1169 YFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEK 1233

  Fly  1055 VYERQVAKQATAKRVID----EQQISRHYNQTDLMELYSYE------------------------ 1091
            :......|....::||.    :|:.|.|..:..|..:..:|
Mouse  1234 ILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPP 1298

  Fly  1092 --LKPSTEREMPI-----LPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHEN------LTEEER 1143
              :.|..| |.|:     :|.|....:::..||:....:...|....:||..|      |.||:.
Mouse  1299 AGVNPDLE-EPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDE 1362

  Fly  1144 KSAW------------AEYEAEK 1154
            ..:|            .|.|.||
Mouse  1363 LPSWIIKDDAEVERLTCEEEEEK 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	65/369 (18%)
		HepA	<382..1071	CDD:440319	185/708 (26%)
		DEXHc_ATRX	455..699	CDD:350826	74/250 (30%)
Smarca4	XP_011240739.1	Med15	62..>237	CDD:312941
		QLQ	191..225	CDD:462622
		Smc	<384..>590	CDD:440809	44/253 (17%)
		HSA	480..552	CDD:214727	13/79 (16%)
		BRK	632..676	CDD:197800	6/50 (12%)
		DEXHc_SMARCA4	751..1001	CDD:350820	90/306 (29%)
		PLN03142	770..>1252	CDD:215601	175/640 (27%)
		SnAC	1342..1409	CDD:464219	11/44 (25%)
		Bromo_SNF2L2	1481..1587	CDD:99947