Protein Alignment XNP and Hltf

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_033236.2
• Gene: Hltf / 20585
• MGIID: 1196437
• Length: 1003
• Species: Mus musculus
• Alignment Length: 1069
• Identity: 232/1069 - (21%)
• Similarity: 376/1069 - (35%)
• Gaps: 366/1069 - (34%)

  Fly   101 KLLASPKT------------KERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIE 153
            ||..:|||            :..||. |:..:|.:..::|:...:..||.    :...::...:|
Mouse   170 KLGPTPKTLGSSLENAWGSGRAGPSY-SRPAHVAVQMTTDQLKTEFDKLF----EDLKEDDRTVE 229

  Fly   154 LSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGT 218
            :..:|.:   |..||   |..|:|......:.:||......|:|........|:.:...|..| .
Mouse   230 MEPAEAI---ETPLL---PHQKQALAWMIARENSKELPPFWEQRNDLYYNTITNFSVKERPEN-V 287

  Fly   219 RRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPA----------------QKPKKMS 267
            ..|.|:.:                         :.|.||..|                ::.||..
Mouse   288 HGGILADD-------------------------MGLGKTLTAIAVILTNFDDGRPLLSKRGKKNH 327

  Fly   268 SDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAA--NSSDSEVMPQRK 330
            ...|....|.|:   |.|..:.:.|...|:....||.    ..||..|:::  .|..|.|.|:|:
Mouse   328 PGKEYKDETIKR---RGSNMDKKEDGHSESSTCGEEP----SISGTPEKSSCTLSQLSSVCPKRR 385

  Fly   331 RRRKKSESDKGSSDFEPEE-KQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDL 394
            :...:......|.:.|..| .||.||                                |.|::.|
Mouse   386 KISVQYIESSDSEEIETSELPQKMKG--------------------------------KLKNVQL 418

  Fly   395 TTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALL----QVDKGLLKKL 455
            .||          .|::...|:                    .|:||.||.    ...:.:|||
Mouse   419 NTK----------SRVKGSSKV--------------------KEDSKFALTFFASATQRKMLKK- 452

  Fly   456 KPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLI 520
                  |:..|  .|.|.....:                              .||.|     ||
Mouse   453 ------GMSMM--ECSEACDTGE------------------------------RTRAT-----LI 474

  Fly   521 ISPLSTVNNWAREFTSWMKF-ANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRIL 584
            |.|||.::||..:|...:|. .:.|....|...|.:|        :.|.::..:.:   ..|.||
Mouse   475 ICPLSVLSNWIDQFGQHVKSEVHLNFYVYYGPDRIRD--------SAWLSKQDIIL---TTYNIL 528

  Fly   585 ANE----------KAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRR 639
            .::          ..|.||                  |:.||||.::|.....:|||..:..:||
Mouse   529 THDYGTKDDSPLHSIKWLR------------------VILDEGHAIRNPNAQQTKAVLELEAERR 575

  Fly   640 IVLTGTPLQNNLREYYCMIQFVKPNLLGTY--KEYMNRFV-NPITNGQYTDSTERDLRLMKHRSH 701
            .||||||:||:|::.:.::.|:|   |..:  :|:..|.: .|:|.|.     |..||.
Mouse   576 WVLTGTPIQNSLKDLWSLLSFLK---LKPFIDREWWYRIIQRPVTTGD-----EGGLRR------ 626

  Fly   702 ILHKLLEGCIQRRDYS-------VLAPYLPPKHEYVVYTTLSELQQKLY-----------GYYMT 748
             |..|::....||..:       ||.  ||.:..::.:.||||.::|:|           |.|.|
Mouse   627 -LQSLIKNITLRRTKTSKIKGKPVLE--LPERKVFIQHITLSEEERKIYQSVKNEGKAAIGRYFT 688

  Fly   749 THREQSGGDVVGKGARLFQDFQDLRRIWTH------------------PMNLRVNSDNVIAK-RL 794
            .      |.|:...|.:......||:|..|                  |..||   ..:|.| ::
Mouse   689 E------GTVLAHYADVLGLLLRLRQICCHTHLLTNGMSSSGPSRSDTPEELR---KMLIEKMKI 744

  Fly   795 LSNDDSDMEGFICDETDEDEAASNSSD------SCETFKSDASMSGLAASSGKVKKRKTRNGNAG 853
            :.:..||.|..||.::......::.:.      .|:...|:...:.......::.
Mouse   745 ILSSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIH---------- 799

  Fly   854 GGDS-----------DSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLL 907
             ||:           |||.|        ||::       ||   ...::|.:.|:   ||.||..
Mouse   800 -GDNLLECPPEELACDSDKE--------SSME-------WK---SSSKINALMHA---LIELRTK 842

  Fly   908 QQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSV 972
            ..    ..|.||.||       ...||||:::..|               .||..:.|||||.:.
Mouse   843 DP----NIKSLVVSQ-------FTTFLSLIETPLK---------------ASGFVFTRLDGSMAQ 881

  Fly   973 EQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQI 1037
            ::|....::|.|.......:.|:|.:|||:|:||.||:||.:.|.:|||:.:.|...|.:|.||.
Mouse   882 KKRVESIQRFQNTEAGSPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRCHRLGQK 946

  Fly  1038 KPCYIYRLIAMGTMEQKVYERQVAKQATA 1066
            :...|.:.|...::|:.:.:.|..|:..|
Mouse   947 QEVIITKFIVKDSVEENMLKIQNTKRDLA 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	56/309 (18%)
		HepA	<382..1071	CDD:440319	173/757 (23%)
		DEXHc_ATRX	455..699	CDD:350826	59/257 (23%)
Hltf	NP_033236.2	DNA-binding. /evidence=ECO:0000250	38..287		27/128 (21%)
		HIRAN	60..153	CDD:400928
		DEXHc_HLTF1_SMARC3	240..638	CDD:350829	120/583 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..373		14/62 (23%)
		HepA	<468..980	CDD:440319	154/626 (25%)
		DEGH box	551..554		2/2 (100%)
		RING-HC_HLTF	749..803	CDD:438172	9/64 (14%)
		Interaction with SP1 and SP3. /evidence=ECO:0000250	919..1003		17/57 (30%)