Protein Alignment XNP and Hells

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_032260.2
• Gene: Hells / 15201
• MGIID: 106209
• Length: 821
• Species: Mus musculus
• Alignment Length: 939
• Identity: 250/939 - (26%)
• Similarity: 375/939 - (39%)
• Gaps: 285/939 - (30%)

  Fly   303 EEEEERKSSGDE------EEAANSSDSEVMPQRKRR-RKKSESDKGSSDF-----------EPEE 349
            ||||:.:::|.|      |||..|.|.|....|.|| :...|.....|.|           |.::
Mouse    16 EEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKK 80

  Fly   350 KQKKKGRKRIKKTSSGES--DGDGDDDKQKNKR------KHIRKIIKTKDLDLTTKEAAKEEDDR 406
            |:|.:.:||..|.:.|:|  ||:|:....|.||      .:|.:::..:::....|:....||:.
Mouse    81 KEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDES 145

  Fly   407 RKR----IEDRQK-------LYNRIFVKSESVEINELVLDFDEESK----KALLQVDK----GLL 452
            ...    :||.||       :.:|:   |::|..|.... ||...|    ....|..|    |::
Mouse   146 SSTTSLCVEDIQKNKDSNSMIKDRL---SQTVRQNSKFF-FDPVRKCNGQPVPFQQPKHFTGGVM 206

  Fly   453 KKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDR 517
            :..:...:..::.:|:            .|...|||..||||||:|.:.   |:.:..:|.....
Mouse   207 RWYQVEGMEWLRMLWE------------NGINGILADEMGLGKTVQCIA---TIALMIQRGVPGP 256

  Fly   518 VLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYR 582
            .|:..||||:.||..||       .|...|:         ||                |.|...|
Mouse   257 FLVCGPLSTLPNWMAEF-------KRFTPEI---------PT----------------LLYHGTR 289

  Fly   583 ILANEKAKGLRKKQREQLMQALVDPGPDL---------------VVCDEGHLLKNEKTSISKAVT 632
            ....:..|.:.|:|....:..:|....::               ::.||||.:||.|..:.:.:.
Mouse   290 EDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELK 354

  Fly   633 RMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMK 697
            |.....:::||||||||||.|.:.::.|:.|::....|.:.:.|  .||:   ...|..|: :.|
Mouse   355 RFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWF--DITS---LSETAEDI-IAK 413

  Fly   698 HRS----HILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDV 758
            .|.    |:||::|...:.||..|.:|..:|||.|.|||..|...|:..|
Mouse   414 EREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFY--------------- 463

  Fly   759 VGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSC 823
                                         ..|..|.::|    |.|                 ||
Mouse   464 -----------------------------TAIVNRTIAN----MFG-----------------SC 478

  Fly   824 ETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDS-DSDLEMLGGLGGGSSVQKDDPSEWWKPFVE 887
            |  |....:|    .:|:.|:|..::.|....|. .|:||.|     .|.:|.:...|  :..||
Mouse   479 E--KETVELS----PTGRPKRRSRKSINYSELDQFPSELEKL-----ISQIQPEVNRE--RTVVE 530

  Fly   888 -----ERELN------------------------------------NVHHSPKLLILLRLLQQCE 911
                 |.|:|                                    .|.:|.|.|||.|:|.:.:
Mouse   531 GNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELK 595

  Fly   912 AIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQRE 976
            ..|.|:|||||....||::..:..|     :|:.|.                 |||||.|..:||
Mouse   596 KRGHKVLVFSQMTSMLDILMDYCHL-----RNFIFS-----------------RLDGSMSYSERE 638

  Fly   977 AMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCY 1041
            .....||  |:....|||:|||||||||||.||:.|:|:|..|||..|.|:..|.:|.||.||..
Mouse   639 KNIYSFN--TDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVV 701

  Fly  1042 IYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQ-------ISRHYNQTD---LMEL-----YSYE 1091
            :|||:...|::||:.||..||:...|.:|.:..       :|:..|..|   ||||     |..|
Mouse   702 VYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYERE 766

  Fly  1092 LKPSTEREMPILPKDRLFAEILTEHEKLI 1120
            :|.|  ||..|..:|   .|:|.:...||
Mouse   767 VKGS--REKVISDED---LELLLDRSDLI 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	50/201 (25%)
		HepA	<382..1071	CDD:440319	198/768 (26%)
		DEXHc_ATRX	455..699	CDD:350826	62/258 (24%)
Hells	NP_032260.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..120		13/41 (32%)
		DEXHc_HELLS_SMARCA6	203..436	CDD:350767	70/285 (25%)
		PLN03142	204..>781	CDD:215601	197/736 (27%)
		helicase domain I	226..238		7/11 (64%)
		helicase domain Ia	258..266		4/7 (57%)
		helicase domain II	334..341		3/6 (50%)
		helicase domain III	363..370		5/6 (83%)
		helicase domain IV	429..439		3/9 (33%)
		helicase domain IVa	547..559		0/11 (0%)
		'helicase domain IVb	602..609		5/6 (83%)
		helicase domain V	655..668		11/12 (92%)
		helicase domain VI	686..693		2/6 (33%)