Protein Alignment XNP and Hel89B

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_321235.5
• Gene: Hel89B / 1281292
• VectorBaseID: AGAMI1_004308
• Length: 2067
• Species: Anopheles gambiae
• Alignment Length: 735
• Identity: 168/735 - (22%)
• Similarity: 284/735 - (38%)
• Gaps: 228/735 - (31%)

  Fly   403 EDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMW 467
            :|.|:::::||:.|  ......:::...||.:..:.|               |:.:|.:||.::|
Mosquito  1427 DDLRQRKMKDRRFL--EYLFSPKTIPDVELPVKINAE---------------LRSYQQSGVNWLW 1474

  Fly   468 DACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDR------VLIISPLST 526
                  .....:..|   ||...||||||||.:.:   |..:..:..:||      .::|.|.:.
Mosquito  1475 ------FLNRYKLHG---ILCDDMGLGKTLQAICI---LAADHHQRSLDRGCAQLPSIVICPPTL 1527

  Fly   527 VNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKG 591
            ..:|                 ||::.::  .|:|..:...:....|
Mosquito  1528 TGHW-----------------VYEVEKF--LPSRFLRPLHYVGLPG------------------- 1554

  Fly   592 LRKKQREQLMQA-----LVDPGPDLV---------------VCDEGHLLKNEKTSISKAVTRMRT 636
                .||||.|.     |:....|:|               :.||||::||.:|..|||:.::..
Mosquito  1555 ----NREQLRQKLGTYNLIVASYDIVRKDIEFFSSVNWNYCILDEGHIIKNGRTKSSKAIKQLVA 1615

  Fly   637 KRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSH 701
            ..|::|:|||:|||:.|.:.:..|:.|..|||.|::..||..||...:...|:.::.........
Mosquito  1616 NHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFSTRFSRPILASRDPKSSPKEQEAGALAME 1680

  Fly   702 ILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQS---------GGD 757
            .||:.:...:.||....:...||||....:...||.||::||..:...|...|         .|.
Mosquito  1681 ALHRQVLPFLLRRVKEDVLTDLPPKITQDLLCELSPLQERLYEDFSRMHLHSSDIRECLENIDGQ 1745

  Fly   758 VVG---KGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNS 819
            :.|   |...:||..:.|:.:..||            |.:||....:.:..:
Mosquito  1746 MAGPANKKTHVFQALRYLQNVCNHP------------KLVLSPSHPEYQMIV------------- 1785

  Fly   820 SDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKP 884
                                |:.    ||||::
Mosquito  1786 --------------------GEF----TRNGSS-------------------------------- 1794

  Fly   885 FVEERELNNVHHSPKLLILLRLLQQCEAIG---------DKLLVFSQSLQSLDVIEHFLSLVDSN 940
                  ::::.||.||.:|.:||..| .||         .:.|:|.|....||::|:.|
Mosquito  1795 ------MDDIEHSAKLPVLKQLLLDC-GIGTNEDVSVNQHRALIFCQLKAMLDIVENDL------ 1846

  Fly   941 TKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGIN 1005
            .|.:             .....|.|||||.....|..:..:||...::  .:.|::|:.||||:|
Mosquito  1847 LKKH-------------LPAVSYLRLDGSVPPSTRHHIVTKFNGDPSI--DVLLLTTQVGGLGLN 1896

  Fly  1006 LVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVI 1070
            |..|:.|:..:..|||..|.|::.|.:|.||.|...:||||...::|:|:...|..|..||..|:
Mosquito  1897 LTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRKSLEEKIMGLQKFKLLTANTVV 1961

  Fly  1071 DEQQISRHYNQTD-LMELYS 1089
            .::..|.....|| |::|::
Mosquito  1962 SDENASMDTMGTDQLLDLFT 1981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	9/56 (16%)
		HepA	<382..1071	CDD:440319	163/714 (23%)
		DEXHc_ATRX	455..699	CDD:350826	65/269 (24%)
Hel89B	XP_321235.5	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		DUF3535	715..1242	CDD:463447
		HepA	<1453..1962	CDD:440319	158/686 (23%)