Protein Alignment XNP and Mi-2

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_061510532.1
• Gene: Mi-2 / 1280662
• VectorBaseID: AGAMI1_012829
• Length: 2152
• Species: Anopheles gambiae
• Alignment Length: 1574
• Identity: 318/1574 - (20%)
• Similarity: 517/1574 - (32%)
• Gaps: 606/1574 - (38%)

  Fly     3 KKNPNARHTDAATPLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNVKASGKAT 67
            |||.:...:|..   .:||..||:.:...:|..:.:|:.:||. ..|..|:.|..|.
Mosquito    84 KKNDSGDESDQK---QSDDGGSSAAAAAAAAAAAAAAAAAESD-YESRPKRGRDRKK-------- 136

  Fly    68 VSSSSDSDQAVANSS-----ANDEEKEP----VC--------KIRIV--PLEKLLASP--KTKER 111
             .|||.|..|.|.:|     :.::||.|    ||        ||...  ..|.|:...  :|..|
Mosquito   137 -GSSSRSGAAAAAASEVEKKSEEKEKMPTIQEVCSSFDLTDVKIEYTEEDFENLVTFKMFQTHVR 200

  Fly   112 PSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSR-----NKNASIIELSDSEEVDEEEESLLVAI 171
            |....:...|.:          ...::|.|.|.|     |.|.|..:.:..|....|||:...|.
Mosquito   201 PILTKENPRVPM----------AKLMMLVAAKWREFCTLNPNISSEDATSGETGGREEETAAAAP 255

  Fly   172 PLPKEAQQTKPEKNSSKASK---------ESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSS-E 226
            |.|:..  .|..::.||...         |..|:.::.::|.|..|.:......|...||.|| :
Mosquito   256 PTPEYV--PKSSRSRSKTENKHDDMVYDDEDEEEEEEVERERTRKSKKGKSGGGGGGGGSSSSNK 318

  Fly   227 RSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEA 291
            :.....:||.:..|     .:::|         ..|.|..|||.|:.|:         ..||.|:
Mosquito   319 KGGGGGNSRKQKVP-----TLKIK---------FGKRKNASSDEEQDAS---------GGSERES 360

  Fly   292 DSDYEAPAAEEEEE--EERKSS------GDEEEAANSSDSEVM-----------PQRKRRRKKSE 337
            |:::|....:.|.:  |..||:      .|...|..:||...:           .::|.:.|||:
Mosquito   361 DAEFEKMLQQSEPDTPERAKSATGGSGGADGGAADEASDQPAVRKKAKTKIGNKSKKKNKSKKSK 425

  Fly   338 SDKGSSDFEPEEKQ-----KKKGR-----------------KRIKKTSSG-------ESDGDGDD 373
            ...|..:.|.|.:.     ::.|.                 ..::.|..|       |::|..|:
Mosquito   426 FPDGGEEGEHEHQDYCEVCQQGGEIILCDTCPKAYHLVCLDPELEDTPEGKWSCPTCEAEGPADE 490

  Fly   374 DKQKNKR-------------------------------------------------KHIRKII-- 387
            |..:::.                                                 ..::||:
Mosquito   491 DDDEHQEFCRVCKDGGELLCCDNCPSAYHTFCLNPPLDDIPDGEWRCPRCSCPPLADKVQKILTW 555

  Fly   388 ---------------------------------------------------------------KT 389
                                                                           :.
Mosquito   556 RWTDKPINPDEPSTSKGAAAAAGGSTRRREYFVKWHEKSYWHCDWITELQLDVHHPLMFRYYTRK 620

  Fly   390 KDLDLTTK--EAAKEEDDRRKRIE------------DRQKLYNRIFVKSESVEINELV------- 433
            .|::...|  ||..|||:|.|||:            :.::.|.|..||.|.:.::.::
Mosquito   621 NDMEEPPKLEEALDEEDNRYKRIQRMRETNCQLNETELEEKYYRYGVKPEWLMVHRVINHRTMRD 685

  Fly   434 -----------LDFDE-----------------------------------------------ES 440
                       |.:|:                                               :.
Mosquito   686 GRTLYLVKWRELSYDQATWEDEEDDIAGLKMAIEYYLDLRANCSQDIGGSGSGGSGSSKKNKKKG 750

  Fly   441 KKALLQVDK-----GLLK----------------------------KLKPHQVAGV---KFMWDA 469
            ::.|.::::     |:.:                            :|.|:|:.|:   ::.|
Mosquito   751 RRRLRELEEEERTAGVKRYTPPPEKPTTDLKRKFEVQPPYLDETGMRLHPYQLEGINWLRYSW-- 813

  Fly   470 CFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREF 534
                      ..|:..|||..||||||:|..|..::|.......|  ..|:..||||:.||.|||
Mosquito   814 ----------ANGTDTILADEMGLGKTIQTATFLYSLYKEGHCRG--PFLVAVPLSTIINWEREF 866

  Fly   535 TSWMKFANRNDIEVYDISRYKDKPTR-IFKLNEW-FNEGGVCILGYDMYRILANEKAKGLRKKQR 597
            .:|..       :.|.|:...||.:| :.:.||. |.||.|  .|....||.|:.....:.....
Mosquito   867 ETWAP-------DFYCITYVGDKESRAVIRENELSFEEGAV--RGGKASRIRASSIKFNVLLTSY 922

  Fly   598 EQLMQALVDPGP---DLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQ 659
            |.:.......|.   .::|.||.|.||:.::...|.:.......:::||||||||||.|.:.::.
Mosquito   923 ELISIDAACLGSIDWSVLVVDEAHRLKSNQSKFFKVLNAYNIAYKLLLTGTPLQNNLEELFHLLN 987

  Fly   660 FVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLP 724
            |:..:......|:.|.|.:        .|.|..::.       ||::|...:.||..:.:...:|
Mosquito   988 FLNKSKFNELAEFQNEFAD--------ISKEEQVKR-------LHEMLGPHMLRRLKADVLKNMP 1037

  Fly   725 PKHEYVVYTTLSELQQKLYGYYMTTHRE---QSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNS 786
            .|.|::|...||.||:|.|.|.:|.:.|   ..||   |....|.....||::...||.
Mosquito  1038 TKSEFIVRVELSPLQKKYYKYILTRNYEALNPKGG---GGACSLINIMMDLKKCCNHPY------ 1093

  Fly   787 DNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGN 851
                                                         :...||...::
Mosquito  1094 ---------------------------------------------LFAAAAEEAQL--------- 1104

  Fly   852 AGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDK 916
              |...:.:|:.|....|                             ||::|.::|:..::.|.:
Mosquito  1105 --GPGGNYELQSLTKAAG-----------------------------KLVLLEKMLRLLKSQGHR 1138

  Fly   917 LLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQ 981
            :|:|||..:.||::|.||            ||          .|..|.|:||..:...|:....:
Mosquito  1139 VLIFSQMTKMLDILEDFL------------EG----------LGYKYERIDGGITGSIRQEAIDR 1181

  Fly   982 FNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLI 1046
            | |........||:|||||||||||..|:.|:|:|..|||.:|.|:..|.:|.||.....|||.:
Mosquito  1182 F-NAPGAPQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFV 1245

  Fly  1047 AMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQT-----DLMELYSYEL-KPSTEREMPILPK 1105
            ...::|::|.:....|......|:......:..|.|     |::...:.|| |...:.|..|...
Mosquito  1246 TRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGTNFTKQELDDILRFGTEELFKEDGKDEEAIHYD 1310

  Fly  1106 DRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNA 1170
            |:..||:|....|.:            ||.||         ||
Mosquito  1311 DKAVAELLDRSNKGV------------EEKEN---------WA---------------------- 1332

  Fly  1171 FGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQELNQNQVIQLVPTYLQQLYNEMN 1235
              |:.:..|..||.|.                     .:|.:|..:.:||:          .|..
Mosquito  1333 --NEYLSSFKVASYST---------------------KEDVEEEAETEVIK----------QEAE 1364

  Fly  1236 NGDPTMYKDLLNLH 1249
            |.||..:..||..|
Mosquito  1365 NSDPAYWVKLLRHH 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	76/570 (13%)
		HepA	<382..1071	CDD:440319	182/876 (21%)
		DEXHc_ATRX	455..699	CDD:350826	71/251 (28%)
Mi-2	XP_061510532.1	None