Protein Alignment XNP and CHD3

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: XP_005256484.1
• Gene: CHD3 / 1107
• HGNCID: 1918
• Length: 2115
• Species: Homo sapiens
• Alignment Length: 1499
• Identity: 300/1499 - (20%)
• Similarity: 493/1499 - (32%)
• Gaps: 537/1499 - (35%)

  Fly    21 DSNSSSVSRRESATESKSASESE--SSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSA 83
            ||.....|.|:...|...:..||  :.|.|...::.|..|..|...:..........|....|||
Human   131 DSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSA 195

  Fly    84 ---------------NDEEKEPVCKIRIVP--LEKLLAS-----PKTKERPSRGSQQKNVTINDS 126
                           ::|:...:...:...  :..|:|.     |.:|.....|::.:..:.|:
Human   196 TLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANN- 259

  Fly   127 SDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLL-------VAIPLPKEAQQTKPEK 184
                |.|||...:.|.      |:....:.:|:|.....|..       .|:|.|..|....|..
Human   260 ----PFKGSAAAVAAA------AAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPI 314

  Fly   185 NSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRR-------GSLSSER--------------- 227
            ..:|..:......::..|.......|  :.:.|.:.       |.|..:|
Human   315 RRAKTKEGKGPGHKRRSKSPRVPDGR--KKLRGKKMAPLKIKLGLLGGKRKKGGSYVFQSDEGPE 377

  Fly   228 -----------SSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKM--------------- 266
                       |..::|.|.:.|.|.|:         |.:.:|.:|.||:
Human   378 PEAEESDLDSGSVHSASGRPDGPVRTKK---------LKRGRPGRKKKKVLGCPAVAGEEEVDGY 433

  Fly   267 SSDSEEAATTSKKSRQ--------------------------RRSKSESEADS-DYEAPAAEEEE 304
            .:|.::.....::..:                          :.|....|.:. .:||...|||.
Human   434 ETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEEY 498

  Fly   305 EEERKSSGDEEEAANSSD--------SEVM---------------------------------PQ 328
            |||.:..|::||..:..:        .|::                                 |.
Human   499 EEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPV 563

  Fly   329 RKRRRKK----------------SESDKGSSDFEP------------------------------ 347
            .|.|.:|                .::| |:.|..|
Human   564 LKGRVQKILHWRWGEPPVAVPAPQQAD-GNPDVPPPRPLQGRSEREFFVKWVGLSYWHCSWAKEL 627

  Fly   348 ----------EEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKH-------------------I 383
                      ...|:|...........|..:.||..||:|.|..|                   :
Human   628 QLEIFHLVMYRNYQRKNDMDEPPPLDYGSGEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEWMTV 692

  Fly   384 RKIIK------------TKDLDLTTKEAAKEEDDRR-KRIEDRQKLYNRIFVKSESVEINELVLD 435
            .:||.            .|..||...::..|||:.. ...|:.::.|.|         ..||::.
Human   693 HRIINHSVDKKGNYHYLVKWRDLPYDQSTWEEDEMNIPEYEEHKQSYWR---------HRELIMG 748

  Fly   436 FDE------ESKKALLQVD------------------------KGLLKKLKPHQVAGVKFMWDAC 470
            .|.      :.||..||.|                        .|.|...:...:..::|.|
Human   749 EDPAQPRKYKKKKKELQGDGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSW--- 810

  Fly   471 FETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFT 535
                     ..|:..|||..||||||:|.:...::|.......|  ..|:.:||||:.||.|||.
Human   811 ---------AQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKG--PFLVSAPLSTIINWEREFQ 864

  Fly   536 SWM-KFANRNDIEVYDISRYKDKPTR-IFKLNEWFNE-----GGVCILGYDMYRILANEKAKGLR 593
            .|. ||        |.::...||.:| |.:.||:..|     ||                .|..:
Human   865 MWAPKF--------YVVTYTGDKDSRAIIRENEFSFEDNAIKGG----------------KKAFK 905

  Fly   594 KKQREQLMQALVDPGPDLV---------------VCDEGHLLKNEKTSISKAVTRMRTKRRIVLT 643
            .|:..|:...::....:|:               |.||.|.|||.::...:.:...:...:::||
Human   906 MKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLT 970

  Fly   644 GTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLE 708
            ||||||||.|.:.::.|:.|......:.::..|         .|.::.| ::.|     ||.||.
Human   971 GTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKED-QIKK-----LHDLLG 1020

  Fly   709 GCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHRE----QSGGDVVGKGARLFQDF 769
            ..:.||..:.:...:|.|.|.:|...||.:|:|.|.|.:|.:.|    :.||:.|.    |....
Human  1021 PHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRGGGNQVS----LLNIM 1081

  Fly   770 QDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSG 834
            .||::...||....|                                             |:|..
Human  1082 MDLKKCCNHPYLFPV---------------------------------------------AAMES 1101

  Fly   835 LAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPK 899
            ....||..:                         ||:.::.                     |.|
Human  1102 PKLPSGAYE-------------------------GGALIKS---------------------SGK 1120

  Fly   900 LLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYF 964
            |::|.::|::.:..|.::|:|||..:.||::|.||        :||              |..|.
Human  1121 LMLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFL--------DYE--------------GYKYE 1163

  Fly   965 RLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIF 1029
            |:||..:...|:....:| |....:...||:|||||||||||..|:.|:|||..|||.:|.|:..
Human  1164 RIDGGITGALRQEAIDRF-NAPGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFS 1227

  Fly  1030 RVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKP 1094
            |.:|.||.....|||.:...::|:::  .||||:.                    |.|....::|
Human  1228 RAHRIGQANKVMIYRFVTRASVEERI--TQVAKRK--------------------MMLTHLVVRP 1270

  Fly  1095 STEREMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEK-TRTV 1158
            ....:...:.|..| .:||....:.:||        ::.|.||   :|..|:...|:.|. .|.:
Human  1271 GLGSKAGSMSKQEL-DDILKFGTEELFK--------DENEGEN---KEEDSSVIHYDNEAIARLL 1323

  Fly  1159 QASQYMSYDRNAFG-NQVMGQFGNASGSV-TSNKIFGFRSDILLQLLNM------KISKDHQELN 1215
            ..:|..:.|.:... |:.:..|..|...| ..:||.....:|:.|..|:      |:.:.|.|..
Human  1324 DRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEKLLRHHYEQQ 1388

  Fly  1216 QNQV 1219
            |..:
Human  1389 QEDL 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	75/520 (14%)
		HepA	<382..1071	CDD:440319	181/776 (23%)
		DEXHc_ATRX	455..699	CDD:350826	66/265 (25%)
CHD3	XP_005256484.1	CHDNT	207..260	CDD:462357	7/57 (12%)
		PHD1_CHD_II	440..482	CDD:277006	1/41 (2%)
		PHD2_CHD_II	517..559	CDD:277007	1/41 (2%)
		CD1_tandem_CHD3-4_like	564..642	CDD:349314	7/78 (9%)
		CD2_tandem_CHD3-4_like	687..741	CDD:349309	10/53 (19%)
		PLN03142	778..>1332	CDD:215601	179/758 (24%)
		DEXHc_CHD3	795..1026	CDD:350813	71/283 (25%)
		DUF1087	<1373..1416	CDD:461922	4/20 (20%)
		CHDII_SANT-like	1437..1576	CDD:461920
		PHA03418	1578..>1727	CDD:177646
		CHDCT2	1797..1923	CDD:462358