Protein Alignment XNP and SRCAP

DIOPT Version :10

• Sequence 1: NP_651398.1
• Gene: XNP / 43080
• FlyBaseID: FBgn0039338
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_006653.2
• Gene: SRCAP / 10847
• HGNCID: 16974
• Length: 3230
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 196/807 - (24%)
• Similarity: 317/807 - (39%)
• Gaps: 171/807 - (21%)

  Fly    10 HTDAATPLTTDDSNSSSVSRRESATESKS-------ASESESSPPRSNTK------QSRTHKNVK 61
            |.|.....|...|:..|.|..:..|.||:       :|.:.||||...::      ..:..::.:
Human   232 HLDFIVGQTEKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEE 296

  Fly    62 ASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLAS--PKTKERPSRGSQQKNVTIN 124
            ...:.|:  ..:..|...::.|...|.|.:.:...:|||:||.|  |:..|.||..||..:...:
Human   297 EDDEETI--EVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDS 359

  Fly   125 DSSD-------EEPLKGSKLVLP--ARKSRNK-----NASIIELSDSEEVDEEEESLLVAIPLPK 175
            |:.|       |||.:..::..|  |...|||     :....|.:.:||..|:||..:.|
Human   360 DTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAA----- 419

  Fly   176 EAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPP 240
             .:|.:.|.:.:....|...:.:.:.:|.....|.|....:|:.......|..:.:|....|.|
Human   420 -EEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPEGP- 482

  Fly   241 RPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEE 305
                         :...:|.|:.....|||.|..:..::. :...:.|:...|..|...:||.|:
Human   483 -------------VEAEEPPQEDSSSQSDSVEDRSEDEED-EHSEEEETSGSSASEESESEESED 533

  Fly   306 EERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGD 370
            .:.:|..||||  ...|..|.....|..::||:|.||....|..
Human   534 AQSQSQADEEE--EDDDFGVEYLLARDEEQSEADAGSGPPTPGP--------------------- 575

  Fly   371 GDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLD 435
                                    ||....||..|              |...:||::.....|
Human   576 ------------------------TTLGPKKEITD--------------IAAAAESLQPKGYTL- 601

  Fly   436 FDEESKKALLQVDKG---LLK-KLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKT 496
                   |..||...   ||: :|:.:|..|:.  |      |....||..:| |||..||||||
Human   602 -------ATTQVKTPIPLLLRGQLREYQHIGLD--W------LVTMYEKKLNG-ILADEMGLGKT 650

  Fly   497 LQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRI 561
            :|.::|...|.......|..  |||.|.|.:.||..|...|..     ..::  ::.|..:..|.
Human   651 IQTISLLAHLACEKGNWGPH--LIIVPTSVMLNWEMELKRWCP-----SFKI--LTYYGAQKERK 706

  Fly   562 FKLNEWF--NEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEK 624
            .|...|.  |...|||..|.:  :|.:.:|  .|:|....|            :.||...:||.|
Human   707 LKRQGWTKPNAFHVCITSYKL--VLQDHQA--FRRKNWRYL------------ILDEAQNIKNFK 755

  Fly   625 TSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDST 689
            :...:::....::||::||||||||:|.|.:.::.|:.|::..:::|:...|.||:| |....|.
Human   756 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLT-GMIEGSQ 819

  Fly   690 ERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYM--TTHRE 752
            |.:..|:|.    |||:|...:.||....:...:|.|:|:|:...||:.|:.||..:|  ||.:|
Human   820 EYNEGLVKR----LHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKE 880

  Fly   753 QSGGDVVGKGARLFQDFQDLRRIWTHP 779
            ..   ..|....:......||::..||
Human   881 TL---ATGHFMSVINILMQLRKVCNHP 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XNP	NP_651398.1	PTZ00121	<173..>460	CDD:173412	52/290 (18%)
		HepA	<382..1071	CDD:440319	111/406 (27%)
		DEXHc_ATRX	455..699	CDD:350826	73/245 (30%)
SRCAP	NP_006653.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		HSA	127..193	CDD:462194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..547		70/318 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..581		8/66 (12%)
		DEXQc_SRCAP	618..840	CDD:350761	77/260 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1017..1045
		PHA03247	<1031..1592	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1058..1125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1138..1166
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1320..1366
		PHA03247	<1366..1834	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1406..1425
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1629..1760
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1839..1893
		SF2_C_SNF	2032..2167	CDD:350180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2214..2233
		COG4372	2241..>2362	CDD:443500
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2271..2298
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2327..2453
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2564..2583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2598..3081
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3095..3230