Protein Alignment TRPM1 and Trpm

DIOPT Version :10

• Sequence 1: NP_001238949.1
• Gene: TRPM1 / 4308
• HGNCID: 7146
• Length: 1642
• Species: Homo sapiens
• Sequence 2: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1900
• Identity: 677/1900 - (35%)
• Similarity: 967/1900 - (50%)
• Gaps: 423/1900 - (22%)

Human    21 KSWIEKTFCKRECIFVIPSMKDSNRCCCG--QFTNQHIPPLPSATPSKNEEESKQVETQPEKWSV 83
            :||||..|.|||||..||..||..:||||  |.|:|.||.:.|.:|.             :.|..
  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPG-------------DLWLP 90

Human    84 AKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQN 148
            .|||:..|||:||.:|||||.:..||.|:|:|:||:|:.|:.|..|:|.||||||||:|.||..|
  Fly    91 TKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKAN 155

Human   149 FEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIV 213
            |::|.|||:...|||:|||.||||||||||.:|||...|||||.....:..|||.:|||||||||
  Fly   156 FDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIV 220

Human   214 ENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKI 278
            |...:|:|.:......::|:|.|||:||||.|.:|:|.||||..|||||:.|||.|||.||..|:
  Fly   221 ERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKL 285

Human   279 NTRLG---------QGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKY 334
            :....         ...|:|.||:|||.|.:..||||:.:.||:|||:|||||||:|:|:|.|||
  Fly   286 HPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKY 350

Human   335 CEEG--GIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGS--EGQ-QDI 394
            ..:|  ..:.||:|:.|:.||||||.....||.:|:..:::|.:.|.|:||||:..  ||: |::
  Fly   351 ASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQEL 415

Human   395 EMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPP 459
            :..|||||.|..::|.|:||||||.|||||||||:|||:|..||.
  Fly   416 DQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPN-------------------- 460

Human   460 MATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGV 524
                                                  .||::||:.||..||:||||||:||||
  Fly   461 --------------------------------------GALDEAMMQALEHDRIDFVKLLLENGV 487

Human   525 NMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYT 589
            :|:.|||||||||||||:.||.|||..::||| :.::|..|..:|.|||||:..|||||||..||
  Fly   488 SMKKFLTIPRLEELYNTKHGPANTLGYILRDV-RPHIPKGYIYTLHDIGLVINKLMGGAYRSYYT 551

Human   590 RKNFRTLY-------------NNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDD 641
            |:.||.:|             ::.:..:|......|.:.....|...:
  Fly   552 RRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSE----------------- 599

Human   642 PAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQ 706
              ::.|::||:||::||||.|||:||:.:|..|||::||:||:||||||||||::|.||..:|.:
  Fly   600 --MALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYE 662

Human   707 DLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQML 771
            :|.:.:|:|.....:|||.||:.|.:.|.:|||.||.:|||.:||.|||||.||..:||.|||::
  Fly   663 ELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVI 727

Human   772 LTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSY--QTSKE-----NEDGKEKEEEN 829
            |.|:|||.||.|||...|||:|:.:|..|..|:|::.::...  ||.:|     |.|..:.:...
  Fly   728 LADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQ 792

Human   830 TDANA---------------DAGSRKGD------------------------------------- 842
            .||.:               .||:...|
  Fly   793 PDAESALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNL 857

Human   843 -EENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISY 906
             |.||.|:.:.:.:..|..|||.|||.|||..:|:|:.:|::|::.:||:|:..|..|||..|:|
  Fly   858 SEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAY 922

Human   907 IVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYC 971
            |.:|..||:|||:.|||..::.|..||....||..|..||..|:||...|.:... |..||||||
  Fly   923 ITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENT-MDIGRVIYC 986

Human   972 VDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWK 1036
            ||.|:||:|:|:|.||||||||.|.|:|||:.:|:||||::.||||||||:|||||:|.::|:|.
  Fly   987 VDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWS 1051

Human  1037 LAR-------------------------------------------------------------- 1039
            |.:
  Fly  1052 LIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPI 1116

Human  1040 -------------NIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLT 1091
                         |:.:.||:|:||||||..||       |||||:      ...|.|:.|.|:|
  Fly  1117 HNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHWVT 1168

Human  1092 PALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHI 1156
            |..|:.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|.|.|.
  Fly  1169 PITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHF 1233

Human  1157 YIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERI 1221
            |.::.    .|.:|.:|.:.:||.||||||..::|:||::|||:||:..|.|:|.....|:|||:
  Fly  1234 YSLLK----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERV 1294

Human  1222 RVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL--------ENLAGIDR 1278
            :.|:||||.||.::|:||::|.....::|.::.||.::||.|.::::.|        .:.||.|
  Fly  1295 KNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGAD- 1358

Human  1279 SDLIQARSRASSECEATYLLRQSSINSADGYS-------------------------------LY 1312
             ||..:......|.:.   :|..||:..:|.|                               ..
  Fly  1359 -DLRGSTINIPGEMQR---MRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTT 1419

Human  1313 RYHFN-------------GEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPECQNSLH 1364
            |..||             .|...||...|...|...|:.:..   :.|:...|..:..|..:.::
  Fly  1420 RRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREA---LNEQVVRKASMQSEADSDIY 1481

Human  1365 LSLGTSTSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPSLNKTD--VIH 1427
            :.:....|              ..|..|..|.:.: ::|....|:||  :|::|..|..|  .:.
  Fly  1482 IPVSQRPS--------------TCETVKRTPYVTV-RQDTGASTESK--DTLTPMGNNDDDQTLV 1529

Human  1428 GQDKSDVQN-------------TQLTV-------ETTNIEGT------------ISYPLEETKIT 1460
            |.|.||...             .|.||       ||.::.|.            .|....:..:|
  Fly  1530 GGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLT 1594

Human  1461 RYFPDETINACKTMKS----RSFVYSR-GRKLVGGVNQDVEYSSITDQQLTTEWQCQ------VQ 1514
            :..||...:|.....|    :|.:::: .|.::  :....||:||||:   .|..|.      |.
  Fly  1595 QSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNIL--LKLHSEYTSITDE---LESVCHMIASPTVS 1654

Human  1515 KITRSHSTDIPYIV---SEAAVQAEHKEQFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSV 1576
            ..:...|.|.|...   :|||...|.|......::::.:.|.:  |...........|.|  :.|
  Fly  1655 LPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGL--IESRGSIDASAQGFE--IGV 1715

Human  1577 KPDQTLGFPSLRSKSLHGHPRNVKSIQGKL---------------DRSGHASSVSSLVIVSGMTA 1626
            ..|.:..:|..|..::...| :..|:.|.|               |.||..|..:.:.|.||...
  Fly  1716 SIDYSHRYPLRRETAVELSP-SKPSVDGDLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQL 1779

Human  1627 EEKKVKKEKASTETE 1641
            :.::..:..:|.|.:
  Fly  1780 KNERPWQRNSSMEQQ 1794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPM1	NP_001238949.1	LSDAT_euk	109..374	CDD:465665	141/275 (51%)
		TRPV	<751..1149	CDD:454755	197/532 (37%)
		TRPM_tetra	1218..1273	CDD:465156	21/62 (34%)
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	141/275 (51%)
		TRPV	<872..1227	CDD:454755	153/368 (42%)
		TRPM_tetra	1291..1346	CDD:465156	21/54 (39%)