Protein Alignment Vps33B and VPS33

DIOPT Version :10

• Sequence 1: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_013500.3
• Gene: VPS33 / 851112
• SGDID: S000004388
• Length: 691
• Species: Saccharomyces cerevisiae
• Alignment Length: 772
• Identity: 155/772 - (20%)
• Similarity: 274/772 - (35%)
• Gaps: 243/772 - (31%)

  Fly    12 FQLVAQEKLCSILCSIPGKKE-LILEPDLIKPLEHVVTASWLKLKGIQRIYKHDAAQSLPRSADQ 75
            |.|...:.||:.|..|....| |:::|.::..|..::|.             .|..||.|
Yeast    10 FSLTNADGLCATLNEISQNDEVLVVQPSVLPVLNSLLTF-------------QDLTQSTP----- 56

  Fly    76 VHIYMIRSVLGTFQTLL-KQLQPVASEEMPDI-----SMKMYHIVCVPSCYSYFQTLLEQAGLYG 134
                 :|.:     ||| .||    |:::|..     .|.:..::.|.:.......||:.|..:.
Yeast    57 -----VRKI-----TLLDDQL----SDDLPSALGSVPQMDLIFLIDVRTSLRLPPQLLDAAQKHN 107

  Fly   135 LVQLH--------------------------------HF------------------NWDFIYF- 148
            |..||                                ||                  .||.:.|
Yeast   108 LSSLHIIYCRWKPSFQNTLEDTEQWQKDGFDLNSKKTHFPNVIESQLKELSNEYTLYPWDLLPFP 172

  Fly   149 --DQGVL------SLELPNLYECLYLQKNTSPLPAVAQSLRLLQMICGQPSLI----------LS 195
              |:.||      ::|..|:|     ..|...|.:..:|:.:..|:....|||          :|
Yeast   173 QIDENVLLTHSLYNMENVNMY-----YPNLRSLQSATESILVDDMVNSLQSLIFETNSIITNVVS 232

  Fly   196 FGHHSSQLMQMAKTLGKLPAPTNPPD-------YG---------GWLVIDRDKDYPASLLTPAIY 244
            .|:.|.:...:.|.  ::.......|       ||         ..::::|:.|....|||...|
Yeast   233 IGNLSKRCSHLLKK--RIDEHQTENDLFIKGTLYGERTNCGLEMDLIILERNTDPITPLLTQLTY 295

  Fly   245 AGLLLEVFEHSSGEILVDNSKNKIRSQRVELLQGKKSKIGVNSASKPCSIRLNSTSDEIYGDNRY 309
            ||:|.:::|.:||..:.:...|                             .|...|:|:.|.::
Yeast   296 AGILDDLYEFNSGIKIKEKDMN-----------------------------FNYKEDKIWNDLKF 331

  Fly   310 KRFAQVSSLIHAQVKALGLELQKLNDMQ-----LDEMHDYVARKLPKLTELKSKVLRHLNASEIV 369
            ..|..:.    .|:..|..|||...|.:     :.|:.::| ..|..|.:.::.:..|...|..|
Yeast   332 LNFGSIG----PQLNKLAKELQTQYDTRHKAESVHEIKEFV-DSLGSLQQRQAFLKNHTTLSSDV 391

  Fly   370 IQMM-----GNFRKLQTLEEDI-----LNNDSRKRLLS-----EIDELLTTDGQRFNTLRLLCLL 419
            ::::     |:|.|:..||.:|     ||||....:|.     |:|:.        ..|||:|||
Yeast   392 LKVVETEEYGSFNKILELELEILMGNTLNNDIEDIILELQYQYEVDQK--------KILRLICLL 448

  Fly   420 HHCVGVAPEELQIFARNY-CNLFGHQELGVFQQLSQAGLLPPLVVEKKAPTKLLSNLPLPKFQQT 483
            ..|.....|:...:.|.: .:.:|.::....:.|::.|..    ..|...|    :|.:...:.|
Yeast   449 SLCKNSLREKDYEYLRTFMIDSWGIEKCFQLESLAELGFF----TSKTGKT----DLHITTSKST 505

  Fly   484 EFQANANRLKLLTSSGDGQDGGSSSK--SQSSGLQTCPSFVFNGTYIPLVAQLC------SILLK 540
            ..|.....:....::...:|..::.|  :::...... :|.::|. :||..:|.      |||..
Yeast   506 RLQKEYRYISQWFNTVPIEDEHAADKITNENDDFSEA-TFAYSGV-VPLTMRLVQMLYDRSILFH 568

  Fly   541 INSAEE---------LSSKLGMIEGLHLHLDS----------GKITPKAYASQVKLNGVADQD-- 584
            ..|:::         :|....:||  .|:.||          |.||.|..|| :|.|.....|
Yeast   569 NYSSQQPFILSREPRVSQTEDLIE--QLYGDSHAIEESIWVPGTITKKINAS-IKSNNRRSIDGS 630

  Fly   585 --MFPLRLRNLFVFIVGGASYAEIAACDFVAKLTG-----AQITVASDSLMAGSDLI 634
              .|........|..:||.:..|||....:.|:.|     .:..:.:|.|:.|:.::
Yeast   631 NGTFHAAEDIALVVFLGGVTMGEIAIMKHLQKILGKKGINKRFIIIADGLINGTRIM 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	149/751 (20%)
VPS33	NP_013500.3	SEC1	14..651	CDD:227487	145/730 (20%)