Protein Alignment Vps33B and Vps33a

DIOPT Version :10

• Sequence 1: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_075250.2
• Gene: Vps33a / 65081
• RGDID: 620643
• Length: 597
• Species: Rattus norvegicus
• Alignment Length: 631
• Identity: 143/631 - (22%)
• Similarity: 271/631 - (42%)
• Gaps: 80/631 - (12%)

  Fly    17 QEKLCSILCSIPGKKELILEPDLIKPLEHVVTASWLKLKGIQRIYKHDAAQSLPRSADQVHIYMI 81
            :.:|...|....|.|.::.:..|..|...:...|.||...:::::....:: ||.:..:..|:::
  Rat    20 RRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTLKGSR-LPAADVKNIIFLV 83

  Fly    82 RSVLGTFQTLLKQLQPVASEEMPDISMKMYHIVCVPSCYSYFQTLLEQAGLYG-LVQLHHFNWDF 145
            |..|.....:.:.   |.||:... ..:.:||:.||......:..|:..|:.| .:....::.|.
  Rat    84 RPRLELMDMIAEN---VLSEDRRG-PTRDFHILFVPRRSLLCEQRLKDLGVLGSFIYREEYSLDL 144

  Fly   146 IYFDQGVLSLELPNLYECLYLQKNTSPLPAVAQSLRLLQMICGQPSLILSFGHHSSQLM-QMAKT 209
            |.||..:||:|..:.::..||:.:.:.|...|:.|..||.:.|....|...|..:.|:. .|.:.
  Rat   145 IPFDGDLLSMESESAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMVRM 209

  Fly   210 LGKLPAPTNP--PDYGGWLVIDRDKDYPASLLTPAIYAGLLLEVFEHSSGEILVDNSKNKIRSQR 272
            ..:.....|.  |.:...|::||:.|....|.:...|.||:.|::.       :.||..|:..::
  Rat   210 KREFTGSQNSVFPVFDNLLLLDRNVDLLTPLASQLTYEGLIDEIYG-------IQNSYVKLPPEK 267

  Fly   273 VELLQGKKSKIGVNSASKPC---SIRLNSTSDEIYGDNRYKRFAQVSSLIHAQVKALGLEL-QKL 333
            .    ..|.:.|......|.   .::||| ::|:|.:.|.|.|..|.|::..:.|.:.... ::.
  Rat   268 F----APKKQGGGGGKDLPTEAKKLQLNS-AEELYAEIRDKNFNAVGSVLSKKAKIISAAFEERH 327

  Fly   334 NDMQLDEMHDYVARKLPKLTELKSKVLRHLNASEIVIQMMGN---FRKLQTLEEDILNNDSRKRL 395
            |...:.|:..:|: :||.:...:..:..|.:.:|::..:..:   |.|| |:|::.::.....::
  Rat   328 NAKTVGEIKQFVS-QLPHMQAARGSLANHTSIAELIKDVTTSEDFFDKL-TVEQEFMSGIDTDKV 390

  Fly   396 LSEIDELLTTDGQRFNTLRLLCLLHHC-VGVAPEELQIFARNYCNLFGHQELGVFQQLSQAGLLP 459
            .:.|::.:.........|||:||...| .|:..:.|..:.|.....:|::.:.....|.:||||
  Rat   391 NNYIEDCIAQKHPLIKVLRLVCLQSVCNSGLKQKVLDYYKREILQTYGYEHILTLNNLEKAGLL- 454

  Fly   460 PLVVEKKAPTKLLSNLPLPKFQQTEFQANANRLKLLTSSGDGQDGGSSSKSQSSGLQTCPSFVFN 524
                  ||.|...:|.|..:          ..|:|.....:.|:            .|..|:|::
  Rat   455 ------KAQTGGRNNYPTIR----------KTLRLWMDDVNEQN------------PTDISYVYS 491

  Fly   525 GTYIPLVAQLCSILLK--INSAEELSSKLGMIEGLHLHLDSGKITPKAYASQVKLNGVADQDMFP 587
            | |.||..:|..:|.:  ..|.||:   |.::.|.|..    :..|.....|.|..        |
  Rat   492 G-YAPLSVRLAQLLSRPGWRSIEEV---LRILPGPHFE----ERQPLPTGLQKKRQ--------P 540

  Fly   588 LRLRNLFVFIVGGASYAEIAACDFVAKLT--GAQITVASDSLMAGS 631
            ...|...||.:||.::|||||..|:::|.  |.:..:|:..|:.||
  Rat   541 GENRVTLVFFLGGVTFAEIAALRFLSQLEDGGTEYVIATTKLINGS 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	140/617 (23%)
Vps33a	NP_075250.2	Sec1	34..590	CDD:460020	140/617 (23%)