Protein Alignment Vps33B and Vps45

DIOPT Version :10

• Sequence 1: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_742069.1
• Gene: Vps45 / 64516
• RGDID: 621267
• Length: 570
• Species: Rattus norvegicus
• Alignment Length: 637
• Identity: 122/637 - (19%)
• Similarity: 220/637 - (34%)
• Gaps: 201/637 - (31%)

  Fly    28 PGKKELILEPDLIKPLEHVVTASWLKLKGI----------QRIYKHDAAQSLPRSADQVHIYMIR 82
            ||.|.|:::.:....:..|.|.|.:..|.:          :.|.||..|           |..:|
  Rat    20 PGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKA-----------ICFLR 73

  Fly    83 SVLGTFQTLLKQLQPVASEEMPDISMKMYHIVCVPSCYSYFQTLLEQAGLYGL---------VQL 138
            .......:|:::|:      .|..|  :|.|        ||..::.::.:..|         .::
  Rat    74 PTKENVDSLIQELR------RPKYS--IYFI--------YFSNVISKSDVKSLAEADEQEVVAEV 122

  Fly   139 HHFNWDFIYFDQGVLSLELPNLYEC--------LYLQKNTSPLPAVAQSLRLLQMICGQPSLILS 195
            ..|..|:|..:..:.||   |:..|        ..|.:.|..|.|:..||:...||..|.|
  Rat   123 QEFYGDYIAVNPHLFSL---NILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLS---- 180

  Fly   196 FGHHSSQLMQMAKTLGKLPAPTNPPDYGGW-----------LVIDRDKDYPASLLTPAIYAGLLL 249
                    .:.||.||:........:|..:           |::||..|....||....|..::.
  Rat   181 --------SEAAKRLGECVKQVISKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVH 237

  Fly   250 EVFEHSSGEILVDNSKNKIRSQRVELLQGKKSKIGVNSASKPCSIRLNSTSDEIYGDNRYKRFAQ 314
            |         |:..:.|:|...||.         |::...:  .:.|::.:||.|.:|.|..||:
  Rat   238 E---------LLGINNNRIDLSRVP---------GISKDLR--EVVLSAENDEFYANNMYLNFAE 282

  Fly   315 VSSLIHAQVKALGLELQK---LNDMQLDEMHDYVA--RKLPKLTELKSKVLRHLNA----SEIVI 370
            :.|    .:|.|..:.||   ....:|:.:.|..|  ...|:..::...|.:|:..    |.:|.
  Rat   283 IGS----NIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVS 343

  Fly   371 QMMGNFRKLQTLEEDILNNDSRKRLLSEIDELLTTDG-QRFNTLRLLCLLHHCVGVAPEELQIFA 434
            :.  |..::..:|:::...:.....|..:..||.... ..|:.:||:.|              :|
  Rat   344 ER--NLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVRLVML--------------YA 392

  Fly   435 RNYCNLFGHQELGVFQQLSQAGLLPPLVVEKKAPTKLLSNLPLPKFQQTEFQANANRLKLLTSS- 498
            .:|             :...:..||.|:|:.::                  :..|.:.:.|.|:
  Rat   393 LHY-------------ERHSSNSLPGLIVDLRS------------------KGVAEKYRKLVSAV 426

  Fly   499 ---GDGQDGGSSSKSQSSGLQTCPSFVFNGTYIPLVAQLCSILLKINSAEELSSKLGMIEGLHL- 559
               |..:..||...|....:.....|                |..:...|.:.::....  ||.
  Rat   427 VEYGGKRVRGSDLFSPKDAVAITKQF----------------LKGLKGVENVYTQHQPF--LHET 473

  Fly   560 --HLDSGKITPKAYASQVKLNGVADQDMFPLRLR----NLFVFIVGGASYAE 605
              ||..||:....|..           :.|..||    ::.||::|||:|.|
  Rat   474 LDHLIKGKLKENLYPY-----------LGPSTLRDRPQDIIVFVIGGATYEE 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	120/634 (19%)
Vps45	NP_742069.1	Sec1	23..546	CDD:460020	120/634 (19%)