Protein Alignment Vps33B and Rop

DIOPT Version :10

• Sequence 1: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_523916.2
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 699
• Identity: 132/699 - (18%)
• Similarity: 257/699 - (36%)
• Gaps: 218/699 - (31%)

  Fly     3 LTLDKKLQGFQLVAQEKLCSILCSIPGKKELILEPDLIKPLE--------HVVTASWLKLKGIQR 59
            |.:||  .|.::|:   .|:.:..|..:...::| |:.|..|        :::|.|...::|:.|
  Fly    42 LVVDK--LGMRMVS---ACTKMHEISAEGITLVE-DINKKREPLPTMDAIYLITPSDESVRGLIR 100

  Fly    60 IYKHDAAQSLPRSADQVHIYMIRSVLGTFQTLLKQLQPVASEEMPDISMKMYHIVCVPSCYSYFQ 124
            .:: :.|:.:.|.|   |::.                   :|..|:   ::::.:|........:
  Fly   101 DFE-NPARPMYRYA---HVFF-------------------TEVCPE---ELFNDLCKSCAAGKIK 139

  Fly   125 TLLEQAGLYGLVQLHHFNWDFIYFDQGVLSLELPNLYECLYLQKNTSPLPAVAQSLRLLQMICGQ 189
            ||.|            .|..|:.::..|.||:.|:.::|||     ||..|..:|..:.::
  Fly   140 TLKE------------INIAFLPYECQVFSLDSPDTFQCLY-----SPAFASIRSKHIERI---- 183

  Fly   190 PSLILSFGHHSSQLMQMAKTLGKLPAPTNPPDYGGWLVIDRDKDYPASLLTPAIYAGLLLEVFEH 254
                      :.|:..:..|||:.|......|:      ||:.|..||:..         ::..:
  Fly   184 ----------AEQIATLCATLGEYPNVRYRSDW------DRNIDLAASVQQ---------KLDAY 223

  Fly   255 SSGEILVDNSKNKIRSQRVELLQG---------------------------KKSKIGVNSASKPC 292
            .:.:..:.....|.|||.:.|.:|                           .:...|.|...|..
  Fly   224 KADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVYRYTPGPNQPDKEV 288

  Fly   293 SIRLNSTSDEIYGDNRYKRFAQVSSLIHAQVKALGLELQKLNDMQLDEMHD--YVARKLPKLTEL 355
               |...:|:::.:.|::..|.||:.:...:|.. .:.:::.......|.|  .:.:|:|:..:.
  Fly   289 ---LLDENDDLWVELRHEHIAVVSTQVTQNLKKF-TDSKRMGSADKSSMRDLSQMIKKMPQYQKE 349

  Fly   356 KSKVLRHLNASEIVIQMMGNF-RKLQTLEEDI-LNNDSRKRLLSE-----IDELLTTDGQRFNTL 413
            .||...||:.:|..::...|: .||..:|:|: :..|:....:.:     :..||..:...::.:
  Fly   350 LSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDAEGEKIKDHMRNIVPILLDANVSNYDKV 414

  Fly   414 RLLCLLHHCVGVAPEELQIFARNYCNLFGHQELG-----VFQQLSQAGLLPPLVVEKKAPTKLLS 473
            |::.|.........||      |...||.|.:|.     :.:.||..|:.......||
  Fly   415 RIIALYVMIKNGISEE------NLTKLFTHAQLSPKDQDMVRNLSCLGINVIADSRKK------- 466

  Fly   474 NLPLPKFQQTEFQANANRLKLLTSSGDGQDGGSSSKSQSSG--------LQTCPSFVFNGTYIPL 530
            ...:|:.::|                      :.|..|.|.        ::.|.....:..:.|.
  Fly   467 QYSVPRKERT----------------------TESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPF 509

  Fly   531 V---AQLCSILLKINSAEELSSKLGMIEGLHLHLDSGKITPKAYASQVKLNGVADQDMFPLRLRN 592
            :   ||      ..|.....|::.|     |.|.|.|:       :|||            .:..
  Fly   510 LEGRAQ------NTNYHAPTSARYG-----HWHKDKGQ-------AQVK------------NVPR 544

  Fly   593 LFVFIVGGASYAEIAACDFVAKLTGA----QITVASDSLMAG----SDL 633
            |.||||||.|.:|: .|.:  ::|.|    ::.|.|..:::.    |||
  Fly   545 LIVFIVGGVSMSEM-RCAY--EVTNAVRNWEVLVGSSHILSPEIFLSDL 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	125/671 (19%)
Rop	NP_523916.2	Sec1	40..589	CDD:460020	129/696 (19%)