Protein Alignment Vps33B and uncp-18

DIOPT Version :10

• Sequence 1: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_499918.1
• Gene: uncp-18 / 176862
• WormBaseID: WBGene00020298
• Length: 562
• Species: Caenorhabditis elegans
• Alignment Length: 692
• Identity: 120/692 - (17%)
• Similarity: 229/692 - (33%)
• Gaps: 222/692 - (32%)

  Fly    30 KKELILEPDLIKP------LEH-------------VVTASWLKL-----KGIQRIYKHDAAQSLP 70
            ||::|  .::::|      |.|             ||..|.|.|     :|:..:      :.|.
 Worm     7 KKQII--ENILRPQNYDSKLGHRKFSVLVLDKSAMVVVNSCLSLNEVFEEGVTLV------EDLT 63

  Fly    71 RSADQV----HIYMIRSVLGTFQTLLKQLQPVASEEMPDISMKMYHIVCV-PSCYSYFQTLLEQA 130
            |:.:.:    .||:|..|..:...|:..... .::..|..|.:..||..: |.|...|:.|.:..
 Worm    64 RNREPMPSMDAIYIISPVAESIDILINDFSR-KTKFNPGNSYRSAHIFFLDPCCDELFEKLSKSP 127

  Fly   131 GLYGLVQL------------------HHFNWDFIYFDQGVLSL-ELPNLYECLYLQKNTSPLPAV 176
            .:..:..|                  ..|..|......|::|| ...|::..|..|.:      .
 Worm   128 AVKWIKTLKELNLNLKPVESQIFTVNSQFRGDMTKTADGIVSLCATLNIHPTLRFQSD------F 186

  Fly   177 AQSLRLLQMICGQPSLILSFGHHSSQLMQMAKTLGKLPAPTNPPDYGGWLVIDRDKDYPASLLTP 241
            |||..:.|                 ::.|..|..|.....|:    ...:|:||..|..:.||..
 Worm   187 AQSSEICQ-----------------RVEQKLKEFGNEGMGTD----AELVVLDRSFDLVSPLLHE 230

  Fly   242 AIYAGLLLEVFEHSSG-----------EILVDNSKNKIRSQRVELLQGKKSKIGVNSASKPCSIR 295
            .....::::|.....|           ||::|.
 Worm   231 VTLQAMVVDVTAFKDGVYRYTEAGDSKEIVLDE-------------------------------- 263

  Fly   296 LNSTSDEIYGDNRYKRFAQVSSLIHAQVKALGLELQKLNDMQLDEMHDY-------VARKLPKLT 353
                .|:.:.|.|:|...:|...::..||    :.:..|..:.:.:.:.       ..|.|....
 Worm   264 ----KDQNWLDLRHKLLPEVMKSVNKMVK----DFKNTNKTEPENIKNQSSKDFSTTVRTLQPYL 320

  Fly   354 ELKSKVLRHLN-ASEIVIQMMGNFRKLQTLEED-----------ILNNDSRKRLLSEIDELLTTD 406
            ::|:|:..::: ..|...:...:..|:..||:|           |.::.:..||.:.|...:.|:
 Worm   321 KMKAKMAAYISLTEECRSKYFDSLEKIIALEQDMAVEHTPEHVRITDSQAVGRLSTFILPAIPTE 385

  Fly   407 GQRFNTLRLLCLLHHCVGVAPEELQIFARNYCNLFGHQELGVFQQLSQAGLLPPLVVEKKAPTKL 471
                ..|||:.:....:|...:|      .|.|                              :|
 Worm   386 ----TRLRLILIFMLTIGKDKDE------QYFN------------------------------RL 410

  Fly   472 LSNLPLPKFQQTEFQANANRLKLLTSSGDGQDGGSSSKSQSSGLQTCPS---FVFNGTYIPLVAQ 533
            |.:..:|   ::|||.    :|.:....|     .:.|||....:..|.   |:.: .:.|.:..
 Worm   411 LHHTDIP---ESEFQI----IKRMLIWRD-----KTQKSQFQHRRPPPEDERFIAS-RWDPKIKN 462

  Fly   534 LCSILLKINSAEELSSKLGMIEGLHLHLDSGKITPKAYASQVKLNGVADQDMFPLRLRNLFVFIV 598
            |...:.:    ..|..:...:.|.....|........|.|     |:|.:   |...|.:.:|:|
 Worm   463 LIEEIYE----RRLDEREFKVAGKKSTSDFRPAASARYGS-----GLAGK---PREKRKIIIFVV 515

  Fly   599 GGASYAEIAACDFVAKLTGAQITVASDSLMAGSDLIATAFNR 640
            ||.:|:|:.....::|.|...:.:.||.::..|..:.:..:|
 Worm   516 GGITYSEMRVAYELSKKTNTTVILGSDEILTPSSFLESLRDR 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	118/683 (17%)
uncp-18	NP_499918.1	Sec1	31..553	CDD:460020	113/660 (17%)