DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alrm and CLV2

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_176717.1	Gene:	CLV2 / 842849	AraportID:	AT1G65380	Length:	720	Species:	Arabidopsis thaliana

Alignment Length:	574	Identity:	130/574 - (22%)
Similarity:	202/574 - (35%)	Gaps:	179/574 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLILPPSYHLATPSSGSGQLRRLWLQDHCSAGI-------------------CTNVVIGRSDYVI 58
            :.:..||..||     ..||..|..||..|..|                   |:|..      .:
plant    13 IFVFSPSLPLA-----QSQLPDLDPQDKASLLIFRVSIHDLNRSLSTWYGSSCSNWT------GL 66

  Fly    59 LSQAPIGGTTMLTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYN 123
            ..|.|.|....||....:::...|      |.|       |.|           |:|.||.|.:|
plant    67 ACQNPTGKVLSLTLSGLNLSSQIH------PSL-------CKL-----------SSLQSLDLSHN 107

  Fly   124 RLKDIPKNIFLGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQ---------------- 172
            .......:.|....||.||:|..|:.......:|.:|||::|:.|:||:
plant   108 NFSGNIPSCFGSLRNLRTLNLSRNRFVGSIPATFVSLKELREVVLSENRDLGGVVPHWFGNFSMN 172

  Fly   173 LEQI--SLGVFSG--------MRKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESE 227
            ||::  |...|.|        ::.|..|||..|.:....|   |....|..||||.|:|:.....
plant   173 LERVDFSFCSFVGELPESLLYLKSLKYLNLESNNMTGTLR---DFQQPLVVLNLASNQFSGTLPC 234

  Fly   228 LLKLQPVFTQLDISGNI--------------FQELTLNF-----------------TMLDVA--- 258
            ....:|..:.|:|:.|.              ...|.|:|                 .|||::
plant   235 FYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISPRLMFSEKLVMLDLSHNG 299

  Fly   259 --------IAHSCDLRRLTVYGVIH-----ELDLHNNSLREMPHIPLAANVSS------------ 298
                    |:.:.:...|.:..:.|     ::.|....|:.:..:.|:.|:.:
plant   300 FSGRLPSRISETTEKLGLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIGNLTY 364

  Fly   299 ---LDLSHNPL-GNLQGNPLRRFTSLLRL-----NLSATGAHELPEGLFKKQSHLQMLDISGNSI 354
               :|||||.| |::..|.:..| .||.|     |||.....|| :.|    ..|::||||.|.|
plant   365 LQVIDLSHNALTGSIPLNIVGCF-QLLALMISNNNLSGEIQPEL-DAL----DSLKILDISNNHI 423

  Fly   355 Y-SLKITIFDSLKALQYFYFQQNN-----------W-NCDFLQLLMSSFVKRKDISFMEDITAPE 406
            . .:.:|: ..||:|:......||           | |..:|.|..:.|..... |::......:
plant   424 SGEIPLTL-AGLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLP-SWLFKFDKIQ 486

  Fly   407 LVDDYVDGIACWYESD-----KQSKKCESGGSDAAMELSVVRNEIKTFTELVEK 455
            :: ||......|:..|     .:.|..::||.:...| ...:.|||....:|.|
plant   487 MI-DYSSNRFSWFIPDDNLNSTRFKDFQTGGGEGFAE-PPGKVEIKISAAVVAK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	85/363 (23%)
		LRR_8	91..149	CDD:290566	16/57 (28%)
		leucine-rich repeat	91..114	CDD:275380	3/22 (14%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR_8	138..197	CDD:290566	24/84 (29%)
		leucine-rich repeat	139..162	CDD:275380	7/22 (32%)
		leucine-rich repeat	163..186	CDD:275380	9/48 (19%)
		LRR_8	185..243	CDD:290566	17/57 (30%)
		leucine-rich repeat	187..210	CDD:275380	7/22 (32%)
		leucine-rich repeat	211..283	CDD:275380	21/118 (18%)
		leucine-rich repeat	284..319	CDD:275380	12/50 (24%)
		LRR_8	318..377	CDD:290566	20/64 (31%)
		leucine-rich repeat	320..343	CDD:275380	9/27 (33%)
		leucine-rich repeat	344..365	CDD:275380	8/21 (38%)
CLV2	NP_176717.1	PLN00113	38..>665	CDD:215061	120/544 (22%)
		leucine-rich repeat	123..146	CDD:275380	7/22 (32%)
		leucine-rich repeat	147..204	CDD:275380	13/56 (23%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	3/22 (14%)
		leucine-rich repeat	266..289	CDD:275380	3/22 (14%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	317..340	CDD:275380	4/22 (18%)
		leucine-rich repeat	341..364	CDD:275380	2/22 (9%)
		leucine-rich repeat	365..388	CDD:275380	9/23 (39%)
		leucine-rich repeat	389..412	CDD:275380	9/27 (33%)
		leucine-rich repeat	413..436	CDD:275380	9/23 (39%)
		leucine-rich repeat	437..460	CDD:275380	4/22 (18%)
		leucine-rich repeat	461..484	CDD:275380	4/23 (17%)
		leucine-rich repeat	550..573	CDD:275380
		leucine-rich repeat	574..596	CDD:275380
		leucine-rich repeat	621..653	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000